Mesenchymal Cell News Volume 15.40 | Oct 10 2023

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    2023-10-10 | MESCN 15.40


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.40 – 10 October, 2023
    TOP STORY

    An Engineered Periosteum for Efficient Delivery of rhBMP-2 and Mesenchymal Progenitor Cells during Bone Regeneration

    Researchers developed a biocompatible, 3D polycaprolactone melt electro-written membrane to act as a mimetic periosteum.
    [npj Regenerative Medicine]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Chiral Cell Nanomechanics Originated in Clockwise/Counterclockwise Biofunctional Microarrays to Govern the Nuclear Mechanotransduction of Mesenchymal Stem Cells

    Chiral engineered microcircle arrays were prepared by photosensitive cross-linking synthesis on cell culture plates to control the clockwise/counterclockwise geometric topology of stem cells.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    POT1a Deficiency in Mesenchymal Niches Perturbs B-Lymphopoiesis

    Scientists showed that genetic deletion of protection of telomeres 1a (POT1a) in MSCs led to intracellular accumulation of fatty acids and excessive reactive oxygen species and DNA damage, resulting in impaired osteogenic-differentiation.
    [Communications Biology]

    Full Article

    Regulation of Base Excision Repair During Adipogenesis and Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells

    The authors investigated how alkyl-damage repair was modulated during adipogenic and osteogenic differentiation, especially focusing on the base excision repair pathway.
    [Scientific Reports]

    Full Article

    Impaired Immunosuppressive Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on T Cells in Aplastic Anemia

    CD3+ T cells were collected and cocultured with aplastic anemia-exosomes and exosomes derived from HD-MSC.
    [Stem Cell Research & Therapy]

    Full Article

    Microvesicles from Bone Marrow-Derived Mesenchymal Stem Cells Promote Helicobacter pylori-Associated Gastric Cancer Progression by Transferring Thrombospondin-2

    Bone marrow-derived MSCs (BMSCs) and thrombospondin-2-deficient BMSCs were treated with or without the supernatant of H. pylori for 12 hours at a multiplicity of infection of 50, and their extracellular vesicles were collected.
    [Cell Communication and Signaling]

    Full Article

    Mutual Regulation between GDF11 and TET2 Prevents Senescence of Mesenchymal Stem Cells

    Investigators characterized the mechanism by which growth differentiation factor 11 (GDF11) reversed aging of MSCs.
    [Journal of Cellular Physiology]

    Abstract

    Thy-1 Knockdown Promotes the Osteogenic Differentiation of GMSCs via the Wnt/β-Catenin Pathway

    Scientists investigated the function of Thy-1 in the osteogenic differentiation of gingival MSCs by reducing the expression of Thy-1 using a lentivirus.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Local Application of Gingiva-Derived Mesenchymal Stem Cells on Experimental Periodontitis in Rats

    MSCs were isolated from the gingiva of rats and characterized. Viability tests and confocal imaging of gingival MSC in hydrogels were performed.
    [Journal of Periodontology]

    Full Article

    The Ameliorating Effects of Mesenchymal Stem Cells Compared to α-Tocopherol on Apoptosis and Autophagy in Streptozotocin-Induced Diabetic Rats: Implication of PI3K/Akt Signaling Pathway and Entero-Insular Axis

    Researchers examined and compared the ameliorative effects of bone marrow-derived MSCs compared to α-tocopherol on apoptosis, autophagy, and β-cell function in a rat model of streptozotocin-induced diabetes.
    [Journal of Cellular Biochemistry]

    Abstract
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    REVIEWS

    Mesenchymal Stromal Cells As Conductors of Adipose Tissue Remodeling

    The authors describe recent advances in their understanding of how functionally distinct tissue-resident MSC subpopulations orchestrate several aspects of physiological and pathophysiological adipose tissue remodeling.
    [Genes & Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    South Korean Scientists’ Outcry Over Planned R&D Budget Cuts

    South Korea’s scientists have been left reeling after the government proposed substantial cuts to the 2024 federal research budget. Government spending on research and development in the country has been among the highest in the world and the announcement has sparked a rare outcry from researchers.
    [Nature]

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    JOB OPPORTUNITIES

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