Mesenchymal Cell News Volume 15.41 | Oct 17 2023

    0
    14








    2023-10-17 | MESCN 15.41


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.41 – 17 October, 2023
    TOP STORY

    Dual siRNA-Loaded Cell Membrane Functionalized Matrix Facilitates Bone Regeneration with Angiogenesis and Neurogenesis

    Scientists designed a genetically functionalized matrix and enabled it to regulate angiogenesis and neurogenesis to accelerate the process of bone defect repair.
    [Small]

    Abstract
    Scientific resources to support your stem cell research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Silica Replicas Derived from Mammalian Cells as an Innovative Approach to Physically Direct Cell Lineage Decisions of Mesenchymal Stem Cells

    By means of a “live-cell” template strategy, silica replicas displaying the same morphology and topography of the mammalian cells used as templates were fabricated.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    Silencing circSERPINE2 Restrains Mesenchymal Stem Cell Senescence via the YBX3/PCNA/p21 Axis

    RNA sequencing analysis of differentially expressed circular RNAs in long-term-cultured MSCs revealed that circSERPINE2 expression was significantly increased in late passages.
    [Cellular And Molecular Life Sciences]

    Full Article

    The Role of Aplnr Signaling in the Developmental Regulation of Mesenchymal Stem Cell Differentiation from Human Pluripotent Stem Cells

    Scientists unveiled the role of apelin receptor signaling during mesoderm and MSC differentiation from pluripotent stem cells through peptide/small molecule activation, overexpression, knock down, or CRISPR/Cas9 mediated knock out of the pathway components.
    [Advanced Biology]

    Abstract

    High-Throughput Multiparametric Quantification of Mechanics Driven Heterogeneity in Mesenchymal Stromal Cell Population

    Researchers reported that MSC population became phenotypically heterogenous and committed to an unwanted osteoprogenitor pathway when it experienced an abnormal mechanically stiff environment, compared to its native softer environment.
    [Advanced Biology]

    Full Article

    Genome-Wide CRISPR Activation Screening in Senescent Cells Reveals SOX5 as a Driver and Therapeutic Target of Rejuvenation

    Scientists performed a genome-wide CRISPR activation screening using a human mesenchymal precursor cell model of the progeroid syndrome.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins As Actionable Immunotherapeutic Targets in Ewing Sarcoma

    The authors analyzed 19 unique Ewing sarcoma patient or cell line-derived xenografts using proteomics to identify surface proteins for potential immunotherapeutic targeting.
    [Clinical Cancer Research]

    Abstract

    The Efficacy of Mesenchymal Stem Cell Treatment and Colistin-Fosfomycin Combination on Colistin-Resistant Acinetobacter baumannii Sepsis Model

    BALB-c mice were divided into treatment groups: MSC, MSC + colistin (C)-fosfomycin (F), and C-F and control groups. Colistin-resistant Acinetobacter baumannii was administered to mice through intraperitoneal injection.
    [European Journal Of Clinical Microbiology & Infectious Diseases]

    Article

    Inokosterone Activates the BMP2 To Promote the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Improve Bone Loss in Ovariectomized Rats

    Researchers investigated the effect of inokosterone on osteoporosis (OP) using osteogenic differentiated bone marrow-derived MSCs and ovariectomy-induced OP rats.
    [Biochemical and Biophysical Research Communications]

    Abstract
    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    REVIEWS

    (B)On(e)-Cohistones and the Epigenetic Alterations at the Root of Bone Cancer

    The authors critically assess existing literature on oncohistones focusing mainly on bone neoplasms.
    [Cell Death & Differentiation]

    Full Article
    INDUSTRY AND POLICY NEWS

    ICR One of Founding Institutions of New Childhood Cancer Non-Profit Company

    The Institute of Cancer Research is one of the founding members of a new not-for-profit company that will enable scientists across the world to test cancer drugs in cell and animal models of childhood cancers.
    [Institute of Cancer Research]

    Press Release
    FEATURED EVENT

    Generation and Application of Organoid Disease Models

    October 29 – November 3, 2023
    Hinxton, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Licensing Manager – Human Uterus in Pregnancy and Disease

    Centre for Trophoblast Research – Cambridge, England, United Kingdom

    Postdoctoral Position – Fusion Oncogene Driven Pediatric Tumors

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    PhD Position – Cell Fate Engineering & Disease Modeling

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    Postdoctoral Research Fellow – Metastatic Disease

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mesenchymal Cell News Twitter