| Vol. 15.42 – 24 October, 2023 |
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| Scientists unveiled that the histone variant macroH2A1 regulated the crosstalk between epigenetics and inflammation in myelodysplastic syndrome-MSCs, potentially affecting their hematopoietic support ability. [Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers studied the relevant mechanism of action and found that applying cyclic tensile stress could promote the osteogenic differentiation of periodontal ligament stem cells and was related to the activation of mitochondrial autophagy. [Cell Proliferation] |
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| Composite alginate hydrogel containing recombinant type III collagen (rCo III) and umbilical cord MSCs were developed. rCo III served as a favorable bioactive molecule, displaying that rCo III administration promoted MSCs proliferation, stemness maintenance, and migration. [International Journal Of Biological Macromolecules] |
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| Platelet lysates-derived extracellular vesicles and human umbilical cord MSC-derived were isolated by size exclusion chromatography and physically characterized by nanoparticle tracking analysis, protein content, and purity. [Bone & Joint Research] |
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| Investigators extracted bone marrow mesenchymal stem cell-derived exosomes (EXO). Electroporation technology was used to load miR-146a-5p into EXO. [Molecular And Cellular Endocrinology] |
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| Researchers combined human clonal bone marrow MSCs (cBMSCs) with cell sheet technology, demonstrating cell sheet fabrication as a method to significantly upregulate the expression of certain immunomodulatory molecules across GMP-grade hcBMSC lines and whole hBMSCs. [Tissue Engineering Part A] |
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| Bone marrow MSCs were cultured and induced to osteogenic differentiation. Then, oe-circ-FKBP5, oe-NC, si-circ-FKBP5, si-NC, miR-205-5p mimic, mimic NC, miR-205-5p inhibitor, inhibitor NC, sh-RUNX2, or sh-NC were transfected into bone marrow MSCs. [Journal Of Orthopaedic Surgery And Research] |
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| The characteristics of the extracellular vesicles from MSC–like cells derived from induced pluripotent stem cells were confirmed by immunoblotting, cryo-transmission electron microscopy, nanoparticle tracking analysis, and their localization in kidneys. [Cytotherapy] |
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| The expression profiles of GSE197840 were downloaded to screen for differentially expressed miRNAs, and the corresponding genes of the identified miRNAs were predicted. miRNA-mRNA co-expression networks were constructed and the genes in these networks were subjected to functional analysis. [Acta Histochemica] |
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| As the fastest animal growing tissue, deer antlers are remarkably cancer-free, despite high cell division rate. The authors try to find the answer to this seemingly contradictory phenomenon based on the currently available information and give insights into possible clinic application. [Cell Death & Differentiation] |
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| Scientists review the biological characteristics of dental pulp stem cells, their potential for bone tissue engineering, and the underlying transcription factors and signaling pathways involved in osteogenic differentiation. [Stem Cells International] |
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| DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis (ALS). [PLOS] |
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| November 11 – 15, 2023 Nashville, Tennessee, United States |
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| Stanford Medicine – Stanford, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Francis Crick Institute – London, England, United Kingdom |
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| St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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