Mesenchymal Cell News Volume 15.42 | Oct 24 2023

    0
    12








    2024-10-24 | MESCN 15.42


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.42 – 24 October, 2023
    TOP STORY

    MacroH2A1.1 as a Crossroad between Epigenetics, Inflammation, and Metabolism of Mesenchymal Stromal Cells in Myelodysplastic Syndromes

    Scientists unveiled that the histone variant macroH2A1 regulated the crosstalk between epigenetics and inflammation in myelodysplastic syndrome-MSCs, potentially affecting their hematopoietic support ability.
    [Cell Death & Disease]

    Full Article
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    PUBLICATIONSRanked by the impact factor of the journal

    Effects of Tension on Mitochondrial Autophagy and Osteogenic Differentiation of Periodontal Ligament Stem Cells

    Researchers studied the relevant mechanism of action and found that applying cyclic tensile stress could promote the osteogenic differentiation of periodontal ligament stem cells and was related to the activation of mitochondrial autophagy.
    [Cell Proliferation]

    Full Article

    Sodium Alginate Hydrogel Integrated with Type III Collagen and Mesenchymal Stem Cell to Promote Endometrium Regeneration and Fertility Restoration

    Composite alginate hydrogel containing recombinant type III collagen (rCo III) and umbilical cord MSCs were developed. rCo III served as a favorable bioactive molecule, displaying that rCo III administration promoted MSCs proliferation, stemness maintenance, and migration.
    [International Journal Of Biological Macromolecules]

    Abstract

    Comparative Effect of Platelet- and Mesenchymal Stromal Cell-Derived Extracellular Vesicles on Human Cartilage Explants Using an Ex Vivo Inflammatory Osteoarthritis Model

    Platelet lysates-derived extracellular vesicles and human umbilical cord MSC-derived were isolated by size exclusion chromatography and physically characterized by nanoparticle tracking analysis, protein content, and purity.
    [Bone & Joint Research]

    Full Article

    The Bone Mesenchymal Stem Cell-Derived Exosomal miR-146a-5p Promotes Diabetic Wound Healing in Mice via Macrophage M1/M2 Polarization

    Investigators extracted bone marrow mesenchymal stem cell-derived exosomes (EXO). Electroporation technology was used to load miR-146a-5p into EXO.
    [Molecular And Cellular Endocrinology]

    Abstract

    Cellular Interactions in Cell Sheets Enhance Mesenchymal Stromal Cell Immunomodulatory Properties

    Researchers combined human clonal bone marrow MSCs (cBMSCs) with cell sheet technology, demonstrating cell sheet fabrication as a method to significantly upregulate the expression of certain immunomodulatory molecules across GMP-grade hcBMSC lines and whole hBMSCs.
    [Tissue Engineering Part A]

    Abstract

    Circular RNA-FK501 Binding Protein 51 Boosts Bone Marrow Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation via Modulating microRNA-205-5p/Runt-Associated Transcription Factor 2 Axis

    Bone marrow MSCs were cultured and induced to osteogenic differentiation. Then, oe-circ-FKBP5, oe-NC, si-circ-FKBP5, si-NC, miR-205-5p mimic, mimic NC, miR-205-5p inhibitor, inhibitor NC, sh-RUNX2, or sh-NC were transfected into bone marrow MSCs.
    [Journal Of Orthopaedic Surgery And Research]

    Full Article

    Extracellular Vesicles from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Enhance the Recovery of Acute Kidney Injury

    The characteristics of the extracellular vesicles from MSC–like cells derived from induced pluripotent stem cells were confirmed by immunoblotting, cryo-transmission electron microscopy, nanoparticle tracking analysis, and their localization in kidneys.
    [Cytotherapy]

    Abstract

    MiR-223–3p Overexpressed Adipose Mesenchymal Stem Cell-Derived Exosomes Promote Wound Healing via Targeting MAPK10

    The expression profiles of GSE197840 were downloaded to screen for differentially expressed miRNAs, and the corresponding genes of the identified miRNAs were predicted. miRNA-mRNA co-expression networks were constructed and the genes in these networks were subjected to functional analysis.
    [Acta Histochemica]

    Full Article
    Your Online Resource for Cell Visualization. View StainsFile.
    REVIEWS

    Deer Antlers: The Fastest Growing Tissue with Least Cancer Occurrence

    As the fastest animal growing tissue, deer antlers are remarkably cancer-free, despite high cell division rate. The authors try to find the answer to this seemingly contradictory phenomenon based on the currently available information and give insights into possible clinic application.
    [Cell Death & Differentiation]

    Abstract

    Dental Pulp Stem Cells for Bone Tissue Engineering: A Literature Review

    Scientists review the biological characteristics of dental pulp stem cells, their potential for bone tissue engineering, and the underlying transcription factors and signaling pathways involved in osteogenic differentiation.
    [Stem Cells International]

    Full Article20
    INDUSTRY AND POLICY NEWS

    FDA Returns Disappointing News for ALS Stem Cell Therapy

    DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis (ALS).
    [PLOS]

    Editorial
    FEATURED EVENT

    Bioengineering for Global Health

    November 11 – 15, 2023
    Nashville, Tennessee, United States

    > See All Events

    JOB OPPORTUNITIES

    Researcher – Tumors and Pre-Cancers

    Stanford Medicine – Stanford, California, United States

    Postdoctoral Associate – Immune Cells in Blood Diseases and GvHD

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Position – Fusion Oncogene Driven Pediatric Tumors

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    PhD Position – Cell Fate Engineering & Disease Modeling

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mesenchymal Cell News Twitter