 | | Vol. 15.42 – 31 October, 2023 |
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| Advanced adult-type soft-tissue sarcoma, excluding dedifferentiated liposarcoma, or bone sarcoma patients, progressing after at least one systemic line, whose tumors overexpressed CDK4, but not CDKN2A at baseline biopsy, were accrued in this single-arm Phase II trial.
[Signal Transduction And Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Human and mouse bone specimens were evaluated, and the results showed that tripartite motif-containing proteins 21 (Trim21) expression was significantly elevated in bone tissues obtained from osteoporosis patients.
[Bone Research] |
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| During in vitro MSC expansion, transglutaminase 2 was required for cell proliferation and self-renewal by preventing premature senescence but had no effect on the expression of surface antigens and oxidative stress-induced cell death.
[Stem Cells International] |
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| Investigators built a prognostic gene signature based on similarities in the immune microenvironments of osteosarcoma patients. Public datasets were used to examine the correlated genes, and the most consistent dominant infiltrating immune cell type was identified.
[Scientific Reports] |
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| Osteoarthritis (OA) cartilage was obtained from OA knees at macroscopically preserved areas and degenerated areas, while control cartilage was collected from non-arthritic knees.
[Scientific Reports] |
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| MSCs were established from fresh and cryopreserved non-clinical grade neonatal porcine islets and bone marrow, as well as from cryopreserved clinical grade neonatal porcine islets.
[Xenotransplantation] |
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| An ovariectomy-induced osteoporosis mouse model and bone marrow MSCs were used to analyze the effects of isoliquiritin on bone regeneration in vivo and in vitro, respectively.
[Phytotherapy Research] |
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| A chimeric human/mouse model of synovitis was created by surgically implanting SCID mice with a piece of human articular cartilage surrounded by RASF.
[Arthritis Research & Therapy] |
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| Scientists propose potential pharmacological candidates that could improve the efficacy of MSC transplantation by enhancing mitochondrial function in patients with diabetes mellitus and related complications.
[Biomedicine & Pharmacotherapy] |
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| The authors discuss recent advancements in understanding the roles of extracellular vesicles and miRNAs in cardiomyocyte differentiation and proliferation.
[Archives Of Biochemistry And Biophysics] |
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| Governor Kathy Hochul announced that New York’s first cell and gene therapy hub will be housed at Roswell Park Comprehensive Cancer Center in Buffalo, Erie County.
[New York State University] |
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| The group behind Plan S has already accelerated the open-access movement. Now it is proposing a more radical revolution for science publishing.
[Nature News] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Turku – Turku, Finland |
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| | Stanford Medicine – Stanford, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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