 | | Vol. 15.43 – 7 November, 2023 |
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| Investigators leveraged and compared the therapeutic properties of MSCs derived from both adipose tissue and hair follicle, which was combined with sponge-like scaffolds made of valorized soy protein and β-chitin.
[Biomaterials Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In order to better understand chondrogenic differentiation, especially the commitment phase, scientists performed transcriptional profiling of MSC differentiation into chondrocytes from early timepoints starting 15 minutes after induction to 16 hours and fully differentiated chondrocytes at 21 days in triplicates.
[Scientific Data] |
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| Researchers investigated whether bone marrow MSC-derived extracellular vesicles can affect rheumatoid arthritis by delivering microRNA-378a-5p to regulate the IRF1/STAT1 axis.
[Journal Of Innate Immunity] |
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| Investigators analyzed the extent of T lymphocyte activation and the levels of Th1/Th2 cytokines of aplastic anemia patients and explored the immunomodulatory effects of bone marrow-MSCs on interleukin-2-stimulated T lymphocyte activation and cytokine production in vitro.
[Clinical And Experimental Medicine] |
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| Scientists investigated the mechanism underlying the alterations in the blood-spinal cord barrier permeability by human umbilical cord MSC-derived small extracellular vesicles after spinal cord injury.
[PeerJ] |
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| Researchers investigated the effects of advanced glycation end products on bone marrow MSCs, elucidating the N6-methyladenosine modification mechanism in diabetes-associated periodontitis.
[Journal Of Translational Medicine] |
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| Administration of secretome derived from hMSCs reduced the development of opioid withdrawal signs, which correlated with a reduction in neuroinflammation in the hippocampus and nucleus accumbens.
[CNS Neuroscience & Therapeutics] |
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| Scientists investigated the mechanism of lncRNA SNHG14 in osteoporosis progression. Bone marrow-derived MSCs were isolated from BALB/c mice.
[Communications Biology] |
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| Researchers performed global miRNA and mRNA expression profiling via next-generation sequencing of liver tissues from MSC-treated acute-on-chronic liver failure (ACLF) mice to identify important signaling pathways and major factors implicated in ACLF alleviation by MSCs.
[Genomics] |
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| Epigenetic machinery controls MSC differentiation through direct modifications to DNA and histones. Understanding the role of epigenetic machinery in MSC is crucial for the development of effective cell-based therapies for degenerative and inflammatory diseases.
[Cell Death & Disease] |
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| The authors discuss the application of MSC-extracellular vesicles in several gastrointestinal (GI) disorders taking into account their mechanism of action, and summarize the challenges and restrictions that need to be overcome to promote their clinical application in the treatment of various GI diseases.
[Inflammopharmacology] |
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| | This grant will explore a cell therapy approach for the treatment of osteoarthritis via the delivery of human MSC and adipose-derived stem cells in the form of three-dimensional hydrogels.
[L2P Researcher] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Turku – Turku, Finland |
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| | Stanford Medicine – Stanford, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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