Mesenchymal Cell News Volume 15.45 | Nov 14 2023

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    2023-11-14 | MESCN 15.44


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.44 – 14 November, 2023
    TOP STORY

    Melatonin Rescues the Mitochondrial Function of Bone Marrow-Derived Mesenchymal Stem Cells and Improves the Repair of Osteoporotic Bone Defect in Ovariectomized Rats

    Scientists postulated that melatonin has the potential to enhance the repair of osteoporotic bone defects by restoring the mitochondrial function of bone marrow-derived MSCs.
    [Journal Of Pineal Research]

    Abstract
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    Human Mesenchymal Stem Cells Derived from Adipose Tissue Showed a More Robust Effect than Those from the Umbilical Cord in Promoting Corneal Graft Survival by Suppressing Lymphangiogenesis

    Researchers compared the efficacy of human adipose MSCs and human umbilical cord MSCs in vitro and in corneal transplantation models to explore the underlying molecular mechanisms and provide a powerful strategy for future clinical applications.
    [Stem Cell Research & Therapy]

    Full Article

    Synergistic Effect of Chitosan-Alginate Composite Hydrogel Enriched with Ascorbic Acid and Alpha-Tocopherol Under Hypoxic Conditions on the Behavior of Mesenchymal Stem Cells for Wound Healing

    The regenerative properties of chitosan-alginate composite hydrogels in skin wound healing under normoxic and hypoxic conditions were investigated in vitro.
    [Stem Cell Research & Therapy]

    Full Article

    Kaempferol Prevents Aseptic Loosening via Enhance the Wnt/β-Catenin Signaling Pathway In Vitro and In Vivo

    In vitro investigations disclosed that Kaempferol effectively enhanced mineralization and alkaline phosphatase activity in bone-marrow MSCs exposed to titanium particles.
    [European Journal Of Medical Research]

    Full Article

    Arsenic Induces Metabolome Remodeling in Mature Human Adipocytes

    Investigators determined the concentration that inhibited 17% of cell viability and investigated the effects of arsenic acute exposure on adipose-derived human MSCs differentiated in vitro into mature adipocytes and treated with sodium arsenite.
    [Toxicology]

    Full Article

    Microporous Annealed Particle (MAP) Scaffold Pore Size Influences Mesenchymal Stem Cell Metabolism and Proliferation without Changing CD73, CD90, and CD105 Expression over Two Weeks

    Scientists demonstrated that MAP microgel diameter could be tuned to control scaffold pore size and, in turn, modulate MSC survivability, proliferation, metabolism, and migration, thereby enhancing bioactivity and guiding future applications of MAP for regenerative medicine.
    [Advanced Biology]

    Full Article

    Exosomal miR-146a-5p Derived from Human Umbilical Cord Mesenchymal Stem Cells Can Alleviate Antiphospholipid Antibody-Induced Trophoblast Injury and Placental Dysfunction by Regulating the TRAF6/NF-κB Axis

    Investigators identified the potential molecular basis of how human umbilical cord MSC-exosomes improved antiphospholipid antibody-induced placental injury and highlighted the functional importance of the miR-146a-5p/TRAF6 axis in the progression of obstetric antiphospholipid syndrome.
    [Journal Of Nanobiotechnology]

    Full Article

    Therapeutic Effects of Mesenchymal/Stromal Stem Cells and Their Derived Extracellular Vesicles in Rheumatoid Arthritis

    Researchers assessed the effect of human MSCs and MSC-extracellular vesicles on CD4+ T cells from patients with rheumatoid arthritis.
    [Stem Cells Translational Medicine]

    Full Article
    Graphical Abstract

    Conservative Hypomethylation of Mesenchymal Stem Cells and Their Secretome Restored the Follicular Development in Cisplatin-Induced Premature Ovarian Failure Mice

    Mildly hypomethylated bone marrow-derived MSCs and their secretome were independently transplanted or infused in premature ovarian failure mice, established via cisplatin-mediated gonadotoxicity.
    [Reproductive Sciences]

    Full Article
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    REVIEWS

    Analogies and Differences Between Dental Stem Cells: Focus on Secretome in Combination with Scaffolds in Neurological Disorders

    The authors describe the similarities and differences between various dental-derived MSCs (DSCs). Their focus was on the secretome of DSCs and their applications in cell therapy for neurological disorders. For neuro-regenerative purposes, the secretome of different DSCs has been tested.
    [Stem Cell Reviews And Reports]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    NurExone
    Biologic Receives FDA Orphan-Drug Designation, Accelerating Development of ExoPTEN therapy for Acute Spinal Cord Injury Treatment

    The designation covers using MSC-derived small extracellular vesicles loaded with short and modified interfering RNA targeting the phosphatase and tensin homolog (PTEN) protein for acute spinal cord injury, as implemented in the company’s ExoPTEN drug under development.
    [NurExone Biologic, Inc. (Globe Newswire)]

    Press Release
    FEATURED EVENT

    Vienna International Symposium

    December 4 – 6, 2023
    Vienna, Austria

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    JOB OPPORTUNITIES

    Assistant Project Scientist – Mesenchymal Progenitor Cells

    University of California – Los Angeles, California, United States

    Scientist Positions – Pharmaceutical Sciences

    China Pharmaceutical University – Nanjing, Jiangsu, China

    Research Assistant – MSC Biofactories

    National University of Singapore – Singapore, Singapore

    Postdoctoral Researcher – Cancer Immunology and Immunotherapy

    University of Turku – Turku, Finland

    Researcher – Tumors and Pre-Cancers

    Stanford Medicine – Stanford, California, United States

    > See All Jobs

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