Mesenchymal Cell News Volume 15.47 | Nov 28 2023

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    2023-11-28 | MESCN 15.47


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.47 – 28 November, 2023
    TOP STORY

    The BRD4-SRPK2-SRSF2 Signal Modulates the Splicing Efficiency of ACSL3 Pre-mRNA and Influences Erastin-Induced Ferroptosis in Osteosarcoma Cells

    Mechanically, bromodomain-containing protein 4 (BRD4) controlled the splicing efficiency of the RNA precursor of acyl-CoA synthase 3 (ACSL3) by recruiting serine rich/threonine protein kinase 2 (SRPK2) to assemble the splicing catalytic platform.
    [Cell Death & Disease]

    Full Article
    Learn about MSC markers, immune cell interactions, and differentiation methods with this free wallchart.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection in Traumatic Brain Injury through the lncRNA TUBB6/Nrf2 Pathway

    Investigators found that administration of human umbilical cord MSC-exosome suppressed traumatic brain injury-induced inflammation and ferroptosis.
    [Brain Research]

    AbstractGraphical Abstract

    Integrin α10β1-Selected Mesenchymal Stem Cells Reduce Pain and Cartilage Degradation and Increase Immunomodulation in an Equine Osteoarthritis Model

    Researchers investigated disease-modifying effects of integrin α10-MSCs. They suggested that integrin α10-MSCs held promise as a disease-modifying osteoarthritis drug.
    [Cartilage]

    Full Article

    High Expression of ACKR1 Predicts a Good Prognosis and Suppresses Sarcoma Cell Progression via Regulating the Tumor Immune Microenvironment

    Scientists analyzed the functions of atypical chemokine receptor 1 (ACKR1) in sarcoma progression and its potential mechanism.
    [Journal of Applied Genetics]

    Abstract

    Induction of Mesenchymal Stem Cell (MSC) Differentiation from iPS Cells Using MSC Medium

    The authors investigated whether induced pluripotent stem (iPSC) cells could be differentiated into MSCs using MSCGM, a commercially available MSC culture system.
    [Dental Materials Journal]

    Abstract

    Fused in Sarcoma Regulates Glutamate Signaling and Oxidative Stress Response

    By obtaining humanized fust-1 amyotrophic lateral sclerosis (ALS) mutations via CRISPR-CAS9, investigators generated a C. elegans ALS model. Homozygous fust-1 ALS mutant and fust-1 deletion animals were viable in C. elegans.
    [Free Radical Biology and Medicine]

    Full ArticleGraphical Abstract

    Bone Marrow Mesenchymal Stem Cells Alleviate Acute Severe Pancreatitis and Promote Lung Repair via Inhibiting NLRP3 Inflammasome in Rat

    The rat acute severe pancreatitis model was established. Serum amylase, lipase, and inflammatory factor levels were measured by ELISA, and the level of tissue injury was assessed by HE staining.
    [Digestive Diseases and Sciences]

    Abstract

    MSCs Overexpressing GDNF Restores Brain Structure and Neurological Function in Rats with Intracerebral Hemorrhage

    Researchers investigated the influences of MSCs overexpressing glial cell-derived neurotrophic factor (GDNF) on the brain structure as well as gait of rats after intracerebral hemorrhage, and explored the possible mechanisms.
    [Molecular Biomedicine]

    Full Article

    Indoleamine 2, 3-Dioxygenase-Transfected Bone Marrow-Derived Mesenchymal Stem Cells Promote Corneal Allograft Survival by Inhibiting T Cell Proliferation: A Rat Study

    Indoleamine 2,3-dioxygenase-transfected bone marrow-derived MSCs were constructed and co-cultured with CD4+CD24− T cells to detect their effects on the proliferation of CD4+CD25−T cells in vitro.
    [Transplant Immunology]

    Abstract
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    REVIEWS

    Spatiotemporal Cellular Dynamics and Molecular Regulation of Tooth Root Ontogeny

    The authors summarize recent discoveries in the underlying mechanisms governing root ontogeny and discusses some recent key findings in developing of new biologically based dental therapies.
    [International Journal Of Oral Science]

    Full Article

    Regulation Mechanisms and Maintenance Strategies of Stemness in Mesenchymal Stem Cells

    Investigators provide a systematic overview of the factors influencing the preservation of MSC stemness, the molecular mechanisms governing it, the strategies for its maintenance, and the therapeutic potential associated with stemness.
    [Stem Cell Reviews And Reports]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Saudi Universities Lose Highly Cited Researchers after Payment Schemes Raise Ethics Concerns

    The number of top researchers affiliated with universities in Saudi Arabia has dropped sharply, months after the institutions were revealed to be enticing eminent scientists abroad to declare a Saudi affiliation—often in exchange for cash—in a bid to boost their rankings.
    [Science Insider]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Position – Inflammation/Regeneration

    Institut Pasteur – Paris, France

    Assistant Project Scientist – Mesenchymal Progenitor Cells and Perivascular Stem Cells

    University of California, Los Angeles – Los Angeles, California, United States

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States

    Scientist Positions – Pharmaceutical Sciences

    China Pharmaceutical University – Nanjing, Jiangsu, China

    Postdoctoral Researcher – Cancer Immunology and Immunotherapy

    University of Turku – Turku, Finland

    > See All Jobs

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