Mesenchymal Cell News Volume 15.48 | Dec 05 2023

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    Jamie Kang
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    2023-12-05 | MESCN 15.48


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.48 – 5 December, 2023
    TOP STORY

    Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis

    Investigators demonstrated that MSC-derived apoptotic vesicles (apoVs) were promising therapeutic agents for bone regeneration. However, clinical translation of MSC-derived apoVs had been hindered due to cell expansion and nuclear substance.
    [ACS Nano]

    Full ArticleGraphical Abstract
    Request a free wallchart on the roles of exosomes in the therapeutic effects imparted by mesenchymal stromal cells.
    PUBLICATIONSRanked by the impact factor of the journal

    The DNA/RNA Helicase DHX9 Orchestrates the KDM2B-Mediated Transcriptional Regulation of YAP1 in Ewing Sarcoma

    Transcriptome profiling combined to bioinformatic analyses disclosed a gene signature commonly regulated by DHX9 and the lysine demethylase KDM2B, with the Hippo pathway regulator YAP1 as a prominent target in Ewing sarcoma.
    [Oncogene]

    Abstract

    Boosting the Therapeutic Potential of Cell Secretome Against Osteoarthritis: Comparison of Cytokine-Based Priming Strategies

    Scientists compared the composition of the conditioned medium obtained after 24 or 72 hours from untreated and cytokine-treated adipose-derived MSCs.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Enhancer-Mediated FOXO3 Expression Promotes MSC Adipogenic Differentiation by Activating Autophagy

    Researchers identified enhancers-mediated gene FOXO3 promoting MSC adipogenic differentiation by activating autophagy.
    [Biochimica Et Biophysica Acta-Molecular Basis Of Disease]

    Full Article

    Local Manufacturing Processes Contribute to Variability in Human Mesenchymal Stromal Cell Expansion While Growth Media Supplements Contribute to Variability in Gene Expression and Cell Function: A Biomedical Excellence for Safer Transfusion (BEST) Collaborative Study

    Scientists assessed the impact on MSC expansion, gene expression, and other characteristics when different laboratories expanded MSCs from cultures initiated with bone marrow−MSC aliquots derived from the same donor source material yet with different growth media.
    [Cytotherapy]

    Abstract

    Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in H2O2-Induced BMSC Death via Modulating the Nrf-2 Signaling Pathway: The Therapeutic Implications in a Rat Model of Spinal Cord Injury

    Researchers studied the possible benefits of combining tauroursodeoxycholic acid with bone marrow MSC transplantation using an animal model of spinal cord injury.
    [Molecular Neurobiology]

    Full Article

    Mechanisms of Wharton’s Jelly-Derived MSCs in Enhancing Peripheral Nerve Regeneration

    Wharton’s jelly-MSCs were isolated from umbilical cords, and acellular nerve grafts (ANGs) or WJ-MSCs-loaded ANGs were transplanted in injury animal model.
    [Scientific Reports]

    Full Article

    Stem Cell Therapy with CRISPR/Cas9-Mediated MALAT1 Delivery Modulates miR-142 and Rescues Wound Healing in Rats with Age-Associated Diabetic Foot Ulcers

    Using qPCR, investigators analyzed metastasis-associated lung adenocarcinoma transcript 1 and miR-142 expression in EPCs and human umbilical cord-MSCs.
    [Archives Of Gerontology And Geriatrics]

    AbstractGraphical Abstract

    Improvement of Inflammation and Abnormal Vascularization by TSP1 Treatment Combined with ADSCs Transplantation in Mice with Induced Polycystic Ovary Syndrome

    Researchers investigated the efficacy of the combined use of adipose-derived MSCs (ADSCs) and thrombospondin 1 (TSP1) in polycystic ovary syndrome mice.
    [Advanced Biology]

    Abstract
    Learn how to be a great STEM mentor to new lab members
    REVIEWS

    A State-of-the-Art Review on the Recent Advances of Mesenchymal Stem Cell Therapeutic Application in Systematic Lupus Erythematosus

    The authors review the mechanisms of immune system modulation by MSCs and the role of these cells in the treatment of systemic lupus erythematosus.
    [Immunological Investigations]

    Abstract
    INDUSTRY AND POLICY NEWS

    Elevai Labs Enters into Licensing Agreement with Yuva Biosciences to Combine Exosome and Mitochondrial Technologies to Develop New Aesthetics Products

    Elevai Labs, Inc. signed a licensing agreement with Yuva Biosciences, Inc. to research and develop means to incorporate Yuva Bioscience’s mitochondrial research with ELEVAI’s PREx™ to develop topical skincare formulations that combine mitochondrial biology with Elevai’s human umbilical MSC-derived exosomes.
    [Elevai Labs, Inc.]

    Press Release
    FEATURED EVENT

    2024 Bones and Teeth Conference GRC

    January 28 – February 2, 2024
    Galveston, Texas, United States

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    JOB OPPORTUNITIES

    Faculty Position – Pediatric Cancer

    University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States

    Postdoctoral Research Associate – Stem Cell Biology

    University of Sydney – Camperdown, Australia

    Postdoctoral Position – Inflammation/Regeneration

    Institut Pasteur – Paris, France

    Assistant Project Scientist – Mesenchymal Progenitor Cells and Perivascular Stem Cells

    University of California, Los Angeles – Los Angeles, California, United States

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States
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