Mesenchymal Cell News Volume 16.00 | Jan 9 2023

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    2024-01-09 | MESCN 16.01


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.00 – 9 January, 2024
    TOP STORY

    Distinct Mesenchymal Cell States Mediate Prostate Cancer Progression

    Researchers employed single-cell RNA sequencing to delineate molecular changes in tumor stroma that influenced prostate cancer progression and metastasis.
    [Nature Communications]

    Full Article
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    Ratiometric Fluorescent Probe Promotes Trans-Differentiation of Human Mesenchymal Stem Cells to Neurons

    Scientists developed a class of fluorescent probes that could be employed to convert human MSCs into neurons in the presence of fibroblast growth factor.
    [ACS Chemical Neuroscience]

    AbstractGraphical Abstract

    Fucoxanthin Diminishes Oxidative Stress Damage in Human Placenta-Derived Mesenchymal Stem Cells through the PI3K/Akt/Nrf-2 Pathway

    Researchers determined whether fucoxanthin protects placenta-derived MSCs (PL-MSCs) from hydrogen peroxide (H2O2)-induced oxidative stress. After characterization, PL-MSCs were co-treated with fucoxanthin and H2O2 for 24 hours or pre-treated with fucoxanthin for 24 hours followed by H2O2 for 24 hours.
    [Scientific Reports]

    Full Article

    The Characteristics and Function of Small Extracellular Vesicles Derived from Bone Marrow and Umbilical Cord Mesenchymal Stromal Cells Are Influenced by Cell Culture Conditions

    Investigators compared extracellular vesicles isolated from bone marrow and umbilical cord-derived MSCs that were exposed to various cell culture conditions and evaluated their anti-inflammatory effects.
    [Stem Cells And Development]

    Abstract

    Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells via the HGF/Akt/STAT3 Signaling Pathway

    Researchers characterized thrombin-primed Wharton’s Jelly (Th.WJ)-derived-MSCs in terms of stem cell markers, differentiation, cell proliferation, and paracrine factors. They demonstrated that compared with naïve MSCs, Th.WJ MSCs significantly enhanced the neuroprotective effects in vitro.
    [Stem Cells And Development]

    Abstract

    Effects of ADSC-Derived Exosome LRRC75A-AS1 on Anti-Inflammatory Function after SCI

    Scientists examined how adipose-derived MSC exosomes could be used to treat spinal cord injury. They analyzed differentially expressed mRNAs in spinal cord injury using bioinformatics data, gene expression profiles in inflammatory cell models, RT-qPCR, and WB
    [Applied Biochemistry And Biotechnology]

    Abstract

    N6 Methyladenosine Eraser FTO Suppresses Staphylococcus aureus-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Ameliorate Osteomyelitis through Regulating the MDM2/TLR4/SLC7A11 Signaling Pathway

    Investigators found that Staphylococcus aureus treatment promoted the accumulation of iron, Fe2+, lipid peroxide, and malondialdehyde, increased TFRC and reduced FTH1 and GPX4 to trigger ferroptosis in rat bone marrow MSCs.
    [Cell Biology International]

    Abstract

    What Happens to the Osteoporotic Bone Mesenchymal Stem Cells? Evidence from RNA Sequencing

    Bone MSCs (BMSCs) were harvested from ovariectomized and sham-operated rats. After checking the characteristics of rat models and stem cells, the BMSCs were carried out for RNA sequencing.
    [International Journal Of Medical Sciences]

    Full ArticleGraphical Abstract

    Independent Mesenchymal Progenitor Pools Respectively Produce and Maintain Osteogenic and Chondrogenic Cells in Zebrafish

    Investigators conducted clonal cell tracking in zebrafish and showed that sox9a+ cells were already committed to either chondrogenic or osteogenic fates during embryonic stages and that respective progenies were independently maintained as mesenchymal progenitor pools.
    [Development Growth & Differentiation]

    Full Article
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    REVIEWS

    Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: Rrom Biology to Clinical Opportunity

    The authors provide an overview of the recent advancements in the biogenesis, isolation, and characterization of MSC-extracellular vesicles, with an emphasis on their functions in cancer therapy resistance.
    [International Journal Of Medical Sciences]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BrainStorm Granted Patents for Allogeneic Exosome Platform-Product in Neurological Disorder Treatments

    Brainstorm Cell Therapeutics Inc. provided an update on the grant and allowance of three patent applications for NurOwn® and NurOwn-Exosomes. The patent grants claims for an isolated population of MSCs for use in treating amyotrophic lateral sclerosis.
    [Brainstorm Cell Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    Tandem Meetings Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMTR®

    February 21 – 24, 2024
    San Antonio, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Regulation of Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Doctoral Training – Mesenchymal Stromal Cell Therapy

    University of Nottingham – Nottingham, England, United Kingdom

    Postdoctoral Scientist – Corneal Regenerative Medicine

    Cedars-Sinai Board – Anaheim, California, United States

    Faculty Position – Pediatric Cancer

    University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States

    Postdoctoral Research Associate – Stem Cell Biology

    University of Sydney – Camperdown, Australia

    > See All Jobs

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