Mesenchymal Cell News Volume 16.02 | Jan 23 2024

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    Jamie Kang
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    2024-01-23 | MESCN 16.02


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.03 – 23 January, 2024
    TOP STORY

    Hierarchically Assembled Nanofiber Scaffold Guides Long Bone Regeneration by Promoting Osteogenic/Chondrogenic Differentiation of Endogenous Mesenchymal Stem Cells

    A 3D vertically aligned nanofiber scaffold (VAS) was developed with long channels and large pore size. The pore of VAS toward the bone marrow cavity after transplantation enabled the scaffolds to recruit bone marrow MSCs from the bone marrow cavity to the defect area.
    [Small]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Glucocorticoid Activates STAT3 and NF-κB Synergistically with Inflammatory Cytokines to Enhance the Anti-inflammatory Factor TSG6 Expression in Mesenchymal Stem/Stromal Cells

    Investigators found that glucocorticoid could enhance the expression of TSG6, a vital tissue repair effector molecule, in IFNγ and TNFα treated human umbilical cord-MSCs.
    [Cell Death & Disease]

    Full Article

    Brg1/PRMT5 Nuclear Complex Epigenetically Regulates FOXO1 in IPF Mesenchymal Progenitor Cells

    Scientists hypothesized that a Brg1/PRMT5 nuclear complex epigenetically regulates critical nodes in idiopathic pulmonary fibrosis (IPF) mesenchymal progenitor cell self-renewal signaling networks. 
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Solvent-Cast 3D Printing with Molecular Weight Polymer Blends to Decouple Effects of Scaffold Architecture and Mechanical Properties on Mesenchymal Stromal Cell Fate

    Scaffold modulus did not affect human MSC differentiation under osteogenic conditions. However, human MSC response was significantly affected by scaffold stiffness in chondrogenic media.
    [Journal Of Biomedical Materials Research Part A]

    Full Article

    Sequential Gene Expression Analysis of Myelodysplastic Syndrome Transformation Identifies HOXB3 and HOXB7 As the Novel Targets for Mesenchymal Cells in Disease

    Researchers described sequential molecular changes and identified biomarkers in MSC of myelodysplastic syndrome (MDS) transformation. MDS-MSC was further isolated and cultured in vitro to determine the potential diagnostic and prognostic value of the identified biomarkers.
    [BMC Cancer]

    Full Article

    Placenta-Derived Mesenchymal Stem Cells Protect Against Diabetic Kidney Disease by Upregulating Autophagy-Mediated SIRT1/FOXO1 Pathway

    Scientists explored the renoprotective effect of placenta-derived MSCs and the potential mechanism of SIRT1/FOXO1 pathway-mediated autophagy in diabetic kidney disease.
    [Renal Failure]

    Full Article

    The Optimized Priming Effect of FGF-1 and FGF-2 Enhances Preadipocyte Lineage Commitment in Human Adipose-Derived Mesenchymal Stem Cells

    To improve safety and graft vitality and to reduce unwanted lineage differentiation, this study refined the methodology by priming adipose-derived MSCs into preadipocytes—unipotent, self-renewing cells.
    [Genes To Cells]

    Abstract

    MSCs Mediate Long-Term Efficacy in a Crohn’s Disease Model by Sustained Anti-Inflammatory Macrophage Programming via Efferocytosis

    Researchers used SAMP-1/YitFc, a chronic and spontaneous murine model of small intestinal inflammation, to study the therapeutic effects and mechanism of action of human bone marrow-derived MSCs.
    [NPJ Regenerative Medicine]

    Full Article

    Tumor-Derived Small Extracellular Vesicles Facilitate Omental Metastasis of Ovarian Cancer by Triggering Activation of Mesenchymal Stem Cells

    The impact of extracellular vesicles and miR-320a-activated adipose-derived MSCs on tumor growth and metastasis was assessed in subcutaneous and orthotopic ovarian cancer xenograft mouse models.
    [Cell Communication And Signaling]

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    REVIEWS

    Mesenchymal Stem Cell-Induced Neuroprotection in Pediatric Neurological Diseases: Recent Update of Underlying Mechanisms and Clinical Utility

    The authors focus on the therapeutic benefits of MSC-based therapies in salient pediatric neurological disorders including cerebral palsy, stroke, and autism.
    [Applied Biochemistry And Biotechnology]

    Abstract
    INDUSTRY AND POLICY NEWS

    EPA Scraps Plan to End Mammal Testing by 2035

    The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035. The hard deadline—imposed in 2019 to accelerate toward nonanimal models such as “organs on a chip”—made EPA unique among US federal agencies.
    [Science Insider]

    Press Release
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    JOB OPPORTUNITIES

    Research Assistant – Systems Biology of Adipose Tissue

    Karolinska Institutet – Solna, Sweden

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    University of Alberta – Edmonton, Alberta, Canada

    Research Assistant – Systems Biology of Adipose Tissue

    Karolinska Institutet – Solna, Sweden

    Research Assistant – Mammal Limb Regeneration

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Fellow – Regulation of Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

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