Mesenchymal Cell News Volume 16.04 | Feb 06 2024

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    2024-02-06 | MESCN 16.05


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.05 – 6 February, 2024
    TOP STORY

    Superoxide Dismutase 2 Promotes the Immunosuppressive Function of Mesenchymal Stem Cells at the Expense of Adipocyte Differentiation

    Investigators demonstrated that the adipocyte differentiation and immunomodulatory function of human adipose tissue-derived MSCs were mutually exclusive.
    [Molecular Therapy]

    AbstractGraphical Abstract
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    Mesenchymal Stem Cells Inhibit Ferroptosis by Activating the Nrf2 Antioxidation Pathway in Severe Acute Pancreatitis-Associated Acute Lung Injury

    Scientists investigated the protective effects of MSCs against severe acute pancreatitis-associated acute lung injury and its underlying mechanisms. They suggested that MSCs mitigate pathological injury, hemorrhage, inflammatory response in lung tissue, and cell damage in RLE-6TN cells.
    [European Journal Of Pharmacology]

    Full Article

    Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization

    Researchers investigated the therapeutic effect of MSCs on airway remodeling in chronic asthma and explored the mechanisms by analyzing the polarization phenotype of macrophages in the lungs.
    [Inflammation]

    Abstract

    Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Pretreated by Monosialoteterahexosyl Ganglioside Alleviate Intracerebral Hemorrhage by Down-Regulating Autophagy

    In vitro, human umbilical cord MSCs were cultured and induced to differentiate into neuron-like cells after they were pretreated with 150 μg/mL monosialoteterahexosyl ganglioside.
    [Experimental Cell Research]

    Abstract

    Calcium Phosphate Coating Enhances Osteointegration of Melt Electrowritten Scaffold by Regulating Macrophage Polarization

    The osteoimmune microenvironment induced by calcium phosphate-coated polycaprolactone could not only enhance the osteogenic differentiation of bone marrow-derived MSCs in vitro but also promote the bone regeneration in vivo.
    [Journal Of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Ameliorate Male Infertility Caused by Busulfan In Vivo and In Vitro

    Investigators explored the functional restoration and mechanism of human umbilical cord MSC exosomes on busulfan-induced injury in GC-1 spg cells and ICR mouse testes.
    [Ecotoxicology And Environmental Safety]

    Full Article

    Dynamic Tracking of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Following Intravenous Administration in Mice Model

    Scientists investigated the biodistribution, homing and clearance of systemically administered human umbilical cord-MSCs in healthy BALB/c mice model.
    [Regenerative Therapy]

    Full Article

    Mesenchymal Stem Cells Alleviate Sepsis-Induced Acute Lung Injury by Blocking Neutrophil Extracellular Traps Formation and Inhibiting Ferroptosis in Rats

    Researchers explored the effects of ferroptosis and neutrophil extracellular traps and observed the therapeutic function of MSCs on sepsis-induced acute lung injury.
    [Peerj Life & Environment]

    Abstract

    Co-Treatment with Bone Marrow-Derived Mesenchymal Stem Cells and Curcumin Improved Angiogenesis in Myocardium in a Rat Model of MI

    Scientists investigated the synergistic effects of co-treating bone marrow MSCs with curcumin on vascular endothelial growth factor levels, in a rat model of myocardial ischemia (MI).
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    Nanotechnology and Bioengineering Approaches to Improve the Potency of Mesenchymal Stem Cell as an Off-the-Shelf Versatile Tumor Delivery Vehicle

    The authors review the preclinical and clinical studies that have evaluated MSCs as a selective tumor delivery tool in various cancer therapy approaches, including gene therapy, immunotherapy, and chemotherapy.
    [Medicinal Research Reviews]

    Abstract

    Mesenchymal Stromal/Stem Cells (MSCs) Know Best: The Remarkable Complexities of Its Interactions with Polymorphonuclear Neutrophils (PMNs)

    Researchers highlighted the intricate interplay between PMNs and MSCs and their profound relevance in healthy and pathological conditions, shedding light on how to best strategize the use of MSCs in the expanding list of diseases with PMN involvement.
    [Stem Cells]

    Abstract
    Graphical Abstract
    INDUSTRY AND POLICY NEWS

    Dana-Farber Retractions: Meet the Blogger Who Spotted Problems in Dozens of Cancer Papers

    The prestigious Dana-Farber Cancer Institute (DFCI) acknowledged that it would seek retractions for 6 papers and corrections for an additional 31 — some co-authored by DFCI chief executive Laurie Glimcher, chief operating officer William Hahn, and several other prominent cancer researchers.
    [Nature]

    Press Release
    FEATURED EVENT

    Nanomaterials in Biomedical Applications

    February 26 – 27, 2024
    Manipal, India

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Rheumatology

    Boston University – Boston, Massachusetts, United States

    Research Assistant- Type 2 Diabetes Mellitus-Induced Osteopathy

    University of Galway – Galway, Ireland, United Kingdom

    Research Assistant – Systems Biology of Adipose Tissue

    Karolinska Institutet – Solna, Sweden

    Assistant Professor – Stem Cell Biology in Rare Diseases

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Fellow – Regulation of Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    > See All Jobs

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