 | | Vol. 16.07 – 27 February, 2024 |
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| Single-cell RNA sequencing was used to identify cell populations and their gene signatures in the spinal enthesis of five patients with ankylosing spondylitis and three healthy individuals.
[Annals Of The Rheumatic Diseases] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that CYP7B1 was the common critical molecule that promoted activation and impeded quiescence of bone marrow-MSCs under inflammatory stimulation. Mechanistically, CYP7B1 degraded 25-hydroxycholesterol into 7α,25-dihydroxycholesterol.
[Cell Chemical Biology] |
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| Human maxillary sinus membrane (hMSM) was isolated into a monolayer using the combined method of physical separation and enzymatic digestion. The localization of MSCs in hMSM was performed by immunohistological staining and other techniques.
[Journal Of Clinical Periodontology] |
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| The authors revealed that the RNA-binding proteins (RBPs) LARP4A and LARP4B were differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate cancer.
[iScience] |
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| Scientists conducted a randomized, placebo-controlled, double-blind clinical trial to assess the efficacy and safety of one bone marrow-derived MSC infusion in twenty patients with moderate to severe cute respiratory distress syndrome caused by COVID-19.
[Bone Marrow Transplantation] |
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| Researchers developed natural biomaterials, including hyaluronic acid, alginate, and gelatin, to mimic the creation of a 3D human MSC extracellular environment and selected hydrogels with high proliferation capacity for 3D MSC culture.
[Scientific Reports] |
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| The authors developed a novel RGD-SF-DNA hydrogel microsphere via a microfluidic system by integrating photopolymerization with self-assembly techniques and then modified with Pep-RGDfKA.
[Bioactive Materials] |
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| Researchers investigated whether apoptotic extracellular vesicles that were isolated from adipose-derived MSCs cultured under hypoxic conditions exerted greater effects on cartilage repair than those that are isolated from cells cultured under normoxic conditions.
[Journal Of Nanobiotechnology] |
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| Investigators presented the adoption of a label-free technique known as “EXODUS” to isolate and purify MSC-extracellular vesicles from the conditioned medium.
[Analytical And Bioanalytical Chemistry] |
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| The authors review the mechanisms of bone marrow MSC-derived exsomes in central nervous system diseases and provide direction for further research.
[Molecular Neurobiology] |
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| The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center.
[UCI News] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | University of Sydney – Sydney, Australia |
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| | University of Southern California – Los Angeles, California, United States |
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| | UC Davis – Davis, California, United States |
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| | BC Provincial Health Services Authority – Vancouver, British Columbia, Canada/p> |
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| | Universitätsklinikum Ulm – Ulm, Germany |
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