Mesenchymal Cell News Volume 16.08 | Mar 5 2024

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    2024-03-05 | MESCN 16.08


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.08 – 5 March, 2024
    TOP STORY

    Single-Cell Guided Prenatal Derivation of Primary Fetal Epithelial Organoids from Human Amniotic and Tracheal Fluids

    Using single-cell analysis, scientists characterized the cellular identities present in human amniotic fluid. Theyidentified and isolated viable epithelial stem/progenitor cells of fetal gastrointestinal, renal, and pulmonary origin.
    [Nature Medicine]

    Full Article
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    PUBLICATIONSRanked by the impact factor of the journal

    Nr4a1 Enhances Wnt4 Transcription to Promote Osteogenic Differentiation of Mesenchymal Stem Cells and Alleviates Inflammation-Inhibited Bone Regeneration

    The authors found that the expression of orphan nuclear receptor Nr4a1, an endogenous repressor of TGF-β1, was suppressed directly by TGF-β1-induced Smad3 and indirectly by Hdac4, respectively.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Activated Mesenchymal Stem/Stromal Cells Promote Myeloid Cell Differentiation via CCL2/CCR2 Signaling

    Investigators explored the impact of MSCs on the differentiation of hematopoietic stem/progenitor cells and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Direct Coupled Electrical Stimulation Towards Improved Osteogenic Differentiation of Human Mesenchymal Stem/Stromal Cells: A Comparative Study of Different Protocols

    Researchers studied the viability, proliferation, and osteogenic differentiation of human bone marrow-derived MSCs when subjected to five different electrical stimulation protocols.
    [Scientific Reports]

    Full Article

    Lin28 Affects the Proliferation and Osteogenic Differentiation of Human Dental Pulp Stem Cells by Directly Inhibiting Let-7b Maturation

    Investigators explored the effects and possible regulatory mechanisms of Lin28 on the proliferation and differentiation of human dental pulp stem cells.
    [BDJ Open]

    Full Article

    Nerve Growth Factor-Preconditioned Mesenchymal Stem Cell-Derived Exosome-Functionalized 3D-Printed Hierarchical Porous Scaffolds with Neuro-Promotive Properties for Enhancing Innervated Bone Regeneration

    MSCs were stimulated with nerve growth factor to regulate exosomal cargoes to improve neuro-promotive potential and facilitate innervated bone regeneration.
    [ACS Nano]

    AbstractGraphical Abstract

    Self-Assembled DNA Composite-Engineered Mesenchymal Stem Cells for Improved Skin-Wound Repair

    DNA-based self-assembled composites were reported that could aid the adhesion of MSCs in skin wounds, enhance MSC viability, and accelerate wound closure and re-epithelialization.
    [Small]

    Abstract

    Osr1-Mediated Mesothelial Transition of Liver Mesenchymal Cells Exacerbates Fibrotic Liver Damage

    Single-cell RNA sequencing with in vivo lineage tracing in non-alcoholic steatohepatitismodel mice reveals a subpopulation of HSCs transitioning back to a state resembling their developmental precursors, mesothelial cells, after liver injury.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Endovascular Transplantation of mRNA-Enhanced Mesenchymal Stromal Cells Results in Superior Therapeutic Protein Expression in Swine Heart

    Using a trans-vessel wall device, investigators delivered chemically modified mRNAs and mRNA-enhanced mesenchymal stromal cells expressing Vascular Endothelial Growth Factor A directly to the heart.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract
    Learn about MSC markers, immune cell interactions, and differentiation methods with this free wallchart.
    REVIEWS

    Optimizing Tissue Engineering for Clinical Relevance in Rotator Cuff Repair

    A gap currently exists between the promising biological factors which have been investigated in animal models and the rotator cuff repair grafts that can be used in the clinical setting.
    [Tissue Engineering Part B-Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    CytoMed Therapeutics Limited Announces Research Collaboration with Singapore Sengkang General Hospital to Advance Injectable Umbilical Cord-Derived Mesenchymal Stem Cells for Cartilage Diseases and Repair

    CytoMed Therapeutics Limited announced that it has entered into a Research Collaboration Agreement with Sengkang General Hospital Pte Ltd to establish proof-of-concept use of an injectable cartilage regeneration therapy that has been developed with donor-sourced, umbilical cord-derived MSCs to treat cartilage injury.
    [CytoMed Therapeutics Limited]

    Press Release
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    JOB OPPORTUNITIES

    Research Assistants – Stem Cell-Derived Beta Cells

    King’s College London – London, England, United Kingdom

    Postdoc Research Associate – Biomaterial-Cell Interactions

    University of Sydney – Sydney, Australia

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Medical Technologist – Clinical Cell Therapy Lab

    BC Provincial Health Services Authority – Vancouver, British Columbia, Canada

    PhD Position – Wound Healing & Skin Regeneration

    Universitätsklinikum Ulm – Ulm, Germany

    > See All Jobs

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