mesenchymal Cell News Volume 16.10 | Mar 19 2024

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    2024-03-19 | MESCN 16.10


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.10 – 19 March, 2024
    TOP STORY

    ATRX Guards Against Aberrant Differentiation in Mesenchymal Progenitor Cells

    Scientists showed in murine mesenchymal progenitor cells that had Atrx deficiency aberrantly activated mesenchymal differentiation programs.
    [Nucleic Acids Research]

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    Abstract
    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Bioreactor-Based Stem Cell Therapy for Liver Fibrosis

    5% liver fibrosis serum was used to induce the therapeutic phenotype of MSCs, and a fluid bioreactor carrying a co-culture system of hepatocytes and MSCs was constructed to produce the therapeutic medium.
    [Biofabrication]

    Full Article

    Directed Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Sustained Release of BMP4 From PBVHx-Based Nanoparticles

    To enhance its osteogenic activity while reducing dosage and administration frequency, investigators developed a novel long-acting BMP4 delivery system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PBVHx) nanoparticles with soybean lecithin-modified BMP4.
    [International Journal Of Biological Macromolecules]

    Full ArticleGraphical Abstract

    Refining the Identity of Mesenchymal Cell Types Associated with Murine Periosteal and Endosteal Bone

    The authors attempted to increase the amount of single cell RNA sequence data for osteoblasts and osteocytes, to compare cells from the periosteum to those inside bone, and to clarify the major categories of cell types associated with murine bone.
    [Journal Of Biological Chemistry]

    Full Article

    AP-1/C-FOS and AP-1/FRA2 Differentially Regulate Early and Late Adipogenic Differentiation of Mesenchymal Stem Cells

    Chromatin immunoprecipitation-sequencing analysis revealed that C-FOS bound mainly to the promoters of WNT1, miR-30a, and ANAPC7 and regulates their expression during mitotic clonal expansion.
    [Journal Of Cellular Biochemistry]

    Abstract

    Injectable Hydrogel to Deliver Bone Mesenchymal Stem Cells Preloaded With Azithromycin to Promote Spinal Cord Repair

    Researchers explored the potential of promoting repair in the injured spinal cord by delivering bone MSCs that had internalized nanoparticles preloaded with azithromycin.
    [ACS Nano]

    AbstractGraphical Abstract

    Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function

    The authors investigated if osteopontin modulated cell senescence and bone regenerative function in human adipose-derived mesenchymal stem cells, and to determine the underlying mechanisms.
    [Stem Cell Reviews And Reports]

    Full Article

    TRPV4 Activator-Containing CMT-Hy Hydrogel Enhances Bone Tissue Regeneration In Vivo by Enhancing Mitochondrial Health

    Scientists demonstrated that transient receptor potential cation channel subfamily V member 4 (TRPV4), a mechanosensitive, thermogated, and nonselective cation channel, was endogenously present in the MSCs.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Combination Therapy of Bone Marrow Mesenchymal Stem Cell Transplantation and Electroacupuncture for the Repair of Intrauterine Adhesions in Rats: Mechanisms and Functional Recovery

    Researchers established the intrauterine adhesion model of the Sprague–Dawley rat using lipopolysaccharide infection and mechanical scratching. Phosphate-buffered saline, bone marrow (B)MSCs alone, and BMSCs combined with electroacupuncture were randomly administered to the rats.
    [Reproductive Sciences]

    Abstract
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    REVIEWS

    Compounding Engineered Mesenchymal Stem Cell-Derived Exosomes: A Potential Rescue Strategy for Retinal Degeneration

    Investigators summarize the recent advances in miRNAs of MSC-derived exosomes (EXOs) as a treatment for retinal degeneration, discussing the strategies and methods for engineering therapeutic MSC-EXOs.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Opportunities and Perspectives for Three Dimensional Culture of Mesenchymal Stem Cell-Derived Exosomes

    Scientists summarize the advantages of three dimensionally-cultured exosomes and introduce the 3D culture system and methods of exosome isolation, providing scientific strategies for the diagnosis, treatment, and prognosis of a wide variety of diseases.
    [Tissue Engineering Part B-Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    KHIDI to Collaborate with UK’s Medical Research Council for Healthcare Research

    The Korea Health Industry Development Institute (KHIDI) has inked a memorandum of understanding with the Medical Research Council, part of the UK’s Research and Innovation (UKRI).
    [Korea Biomedical Review]

    Press Release
    FEATURED EVENT

    Microsymposium on RNA Biology

    April 24 – 26, 2024
    Vienna, Austria

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Liposarcoma, Breast Cancer, and NSCLC

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Lab Assistant – Mesenchymal Stem Cell Culture Techniques

    University of California, Davis – Sacramento, California, United States

    Research Assistants – Stem Cell-Derived Beta Cells

    King’s College London – London, England, United Kingdom

    Postdoctoral Research Associate – Biomaterial-Cell Interactions

    University of Sydney – Sydney, Australia

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    > See All Jobs

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