 | | Vol. 16.11 – 26 March, 2024 |
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| The authors characterized the soft-tissue sarcomas microenvironment using murine models with distinct immune composition by scRNA-seq, and identify a subset of cancer-associated fibroblasts (CAFs) they termed glycolytic CAFs.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To mimic alveolar soft-part sarcoma angiogenic microenvironment, a microfluidic coculture vasculature chip has been developed as a 3D spheroid composed of mouse alveolar soft-part sarcoma, a layer of pericytes, and endothelial cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers systematically screened a range of nonviral vectors to identify optimal transfection conditions for mRNA delivery to MSCs.
[Molecular Pharmaceutics] |
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| Scientists investigated the role of erythropoietin receptor, which regulated the microenvironment-modulating function of MSCs, in eriodontal ligament stem cell-based periodontal therapy.
[Scientific Reports] |
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| The authors showed that in osteogenic cultures of adipose-derived stem cells, Noggin activated fibroblast growth factor receptors (FGFRs), Src/Akt and ERK kinases, and it stabilized TAZ proteins in the presence of dexamethasone.
[Scientific Reports] |
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| Scientists explored the feasibility of chemically inducing human amniotic membrane MSCs (hAMSCs) to differentiate into cardiomyocytes in vitro. Human amniotic membrane samples were obtained from routine cesarean sections at Far Eastern Memorial Hospital.
[Heliyon] |
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| Inspired by the local use of total flavonoids of Rhizoma Drynariae in the treatment of fracture, a novel 3D-printed HA/CMCS/PDA/TFRD scaffold with anti-infection, biodegradable and induced angiogenesis was designed, and to explore its preclinical value in segmental bone defect of tibia.
[International Journal of Surgery] |
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| Scientists investigated the therapeutic potential of bone marrow-derived MSCs treatments in spontaneous chronic colitis using the Winnie mouse model which closely replicated the presentation and inflammatory profile of ulcerative colitis.
[Scientific Reports] |
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| The authors provide a focused and detailed discussion on MSC-based gene therapy using interleukins and interferons, engineering techniques and insights on potential future advancements.
[Cytokine & Growth Factor Reviews] |
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| Scientists review of the factors influencing the efficacy of MSCs transplantation and its association with platelet concentrates, investigating the impact of platelet concentrates’ composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of treatments.
[Cell Transplantation] |
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| With the goal of creating therapeutics that can help the body prevent or reverse the progression of osteoarthritis without surgical intervention, researchers at Washington University in St. Louis have received an award of up to $31 million from the Advanced Research Projects Agency for Health.
[Washington University] |
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| Charles River Laboratories International, Inc. and National University of Singapore’s Yong Loo Lin School of Medicine announced a High Quality plasmid DNA development and manufacturing agreement.
[Charles River Laboratories International, Inc. (Yahoo Finance)] |
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| May 2 – 3, 2024
Helsingør, Denmark |
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| | University of Colorado – Aurora, Colorado, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | King’s College London – London, England, United Kingdom |
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| | University of Sydney – Sydney, Australia |
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| | UC Davis – Davis, California, United States |
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