Mesenchymal Cell News Volume 16.12 | Apr 2 2024

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    2024-04-02 | MESCN 16.12


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.12 – 2 April, 2024
    TOP STORY

    Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

    Through assembling cell-laden modules, the macrophage-MSC, endothelial cell-MSC, and chondrocyte-MSC co-culture models were successfully established.
    [Advanced Materials]

    Abstract
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    Mapping Cell-to-Tissue Graphs Across Human Placenta Histology Whole Slide Images Using Deep Learning with HAPPY

    The authors developed the ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method for quantifying the variability of cells and micro-anatomical tissue structures across placenta histology whole slide images.
    [Nature Communications]

    Full Article

    Non-Catalytic Role of Phosphoinositide 3-Kinase in Mesenchymal Cell Migration through Non-Canonical Induction of p85β/AP2-Mediated Endocytosis

    Investigators reported that a disordered region of inter SH2 domain contained AP2 binding motifs which could trigger clathrin and dynamin-mediated endocytosis independent of PI3K catalytic activity.
    [Nature Communications]

    Full Article

    Human Dental Pulp Stem Cells Derived Extracellular Matrix Promotes Mineralization via Hippo and Wnt Pathways

    Researchers investigated the efficacy of decellularized extracellular matrix derived from human dental pulp stem cells and gingival-derived mesenchymal stem cells as an inductive scaffold for osteogenic differentiation of gingival-derived mesenchymal stem cells.
    [Scientific Reports]

    Press Release

    Osteogenic Differentiation of Human Mesenchymal Stem Cells on Electroactive Substrates

    The authors investigated the effect of electroactivity and electrical charge distribution on the biological response of human bone marrow stem cells cultured in monolayer on flat poly(vinylidene fluoride) substrates.
    [Heliyon]

    Full Article

    Inhibition of ZDHHC16 Promoted Osteogenic Differentiation and Reduced Ferroptosis of Dental Pulp Stem Cells by CREB

    The lentiviral vectors zinc finger DHHC-type palmitoyl transferases 16 (ZDHHC16) or si-ZDHHC16 were introduced in the dental pulp stem cells and then the cells were induced by an odontogenic medium for 21 days.
    [BMC Oral Health]

    Full Article

    Mesenchymal Stem Cells Alleviate Mouse Liver Fibrosis by Inhibiting Pathogenic Function of Intrahepatic B Cells

    Researchers postulated that MSCs could potentially suppress the pro-fibrotic activity of intrahepatic B cells, thereby inhibiting liver fibrosis progression.
    [Hepatology]

    AbstractGraphical Abstract

    Precision Delivery of Human Bone Marrow-Derived Mesenchymal Stem Cells into the Pancreas Via Intra-Arterial Injection Prevents the Onset of Diabetes

    Using a mouse model, in which repetitive low doses of streptozotocin induced a gentle, but progressive, hyperglycemia, investigators tested bone marrow-derived MSCs which were shown to be enriched with pro-angiogenic and immunomodulatory factors.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Characterization of the Biological and Transcriptomic Landscapes of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple Myeloma

    Scientists isolated and identified bone marrow-MSCs from ten primary multiple myeloma patients and ten healthy donors.
    [Cancer Cell International]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Therapeutic and Immunomodulatory Potentials of Mesenchymal Stromal/Stem Cells and Immune Checkpoints Related Molecules

    Immune checkpoints and their ligands can be produced by MSCs and affect immune cell responses both through their secretion into the microenvironment or direct cell-to-cell interaction.
    [Biomarker Research]

    Full Article

    Adipose-Derived Stem Cell-Based Optimization Strategies for Musculoskeletal Regeneration: Recent Advances and Perspectives

    Investigators summarize recent advances in adipose-derived stem cell (ADSC) and their optimization strategies, including ADSC-derived exosomes, biomaterials, and genetic modifications.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Duke Awarded Up to $33 Million to Develop OA Therapies that Rebuild Bone and Joints

    Duke Health is part of a multi-institution research team receiving federal Advanced Research Projects Agency for Health funding to develop an osteoarthritis (OA) treatment that regenerates joints.
    [Duke University]

    Press Release
    FEATURED EVENT

    12th Annual Symposium on Global Cancer Research

    May 6-9, 2024
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    JOB OPPORTUNITIES

    University Assistant – Veterinary Regenerative Medicine

    University of Veterinary Medicine Vienna – Vienna, Austria

    Laboratory Sciences Professional – Mesenchymal Stromal Cells

    University of Colorado – Aurora, Colorado, United States

    Postdoctoral Research Fellow – Liposarcoma, Breast Cancer, and NSCLC

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Pathology

    The University of Hong Kong – Hong Kong, Hong Kong

    Research Assistants – Stem Cell-Derived Beta Cells

    King’s College London – London, England, United Kingdom

    > See All Jobs

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