| Vol. 16.14 – 16 April, 2024 |
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| Investigators successfully prepared cell membrane vesicles from bone marrow MSCs (BMSCs) and endothelial cells. The results showed that BMSC-derived cell membrane vesicles possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental cells. [Bone Research] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers verified whether MSC-derived extracellular vesicles promoted cartilage damage repair mediated by microfractures and to explore the repair mechanisms. [Journal of Nanobiotechnology] |
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| The GSE14359 chip from the GEO database was used to screen differentially expressed genes in osteosarcoma (OS). DNA polymerase epsilon 2 (POLE2) was confirmed to overexpress in OS tissues and cell lines by immunohistochemical staining, qPCR, and Western blot. [Cell Death Discovery] |
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| The authors used an in vitro system to compare the priming of human MSCs by two inflammatory inducers TNF-α and CRX-527 on exosome molecular cargo, as well as on an in vivo rat ligament injury model to validate exosome potency. [Stem Cells] |
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| Scientists assessed the effects of four commonly used culture media on goat adipose tissue-derived MSC culture characteristics, stem cell-specific immunophenotype, and differentiation. [Scientific Reports] |
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| The authors showed that conditioned media derived from adipose tissue cultures enriched in precursor cells impinge on mitochondrial Ca2+ homeostasis of target cells. [Scientific Reports] |
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| Researchers compared MSCs, MSC derived apoptotic vesicles (MSC-apoVs), and MSC-exosomes from two types of MSC. They generated a map of miRNAs specific to MSC-apoVs and identified seven miRNAs specifically enriched in MSC-apoVs compared to MSCs and MSC-exosomes. [International Journal of Oral Science] |
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| Exosomes derived from normal and hypophosphatasia human bone marrow MSCs were isolated and identified by ultracentrifugation, transmission electron microscopy, and nanoparticle size measurement. [Journal of Nanobiotechnology] |
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| Scientists transplanted separated adipose-derived stromal cells into local subcutaneous adipose tissues of nude mice as an in vivo cell culture model. [Mechanisms of Ageing and Development] |
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| MSCs regulate apoptosis through multiple molecules and pathways, including three classical apoptotic signaling pathways and other pathways. The authors summarize the current evidence on the regulation of apoptosis by MSCs. [Cell Death & Disease] |
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| Investigators analyzed and critically appraised all preclinical studies using cell therapy or cell-derived extracellular vesicles for uveitis, and provided insight into mechanisms regulating ocular inflammation. [Eye] |
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| Researchers at the University of Arkansas for Medical Sciences (UAMS) will use a $2.27 million grant from the NIH to answer key questions about the cellular mechanisms used by estrogen to prevent bone loss and osteoporosis. [University of Arkansas for Medical Sciences] |
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| May 9 – 12, 2024 Melbourne, Australia |
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| University of Dundee – Dundee, Scotland, United Kingdom |
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| University of Dundee – Dundee, Scotland, United Kingdom |
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| University of Oregon – Eugene, Oregon, United States |
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| University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| The University of Hong Kong – Hong Kong, Hong Kong |
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