Mesenchymal Cell News Volume 16.14 | Apr 16 2024

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    2024-04-16 | MESCN 16.14


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.14 – 16 April, 2024
    TOP STORY

    Cell Membrane Vesicles Derived From hBMSCs and hUVECs Enhance Bone Regeneration

    Investigators successfully prepared cell membrane vesicles from bone marrow MSCs (BMSCs) and endothelial cells. The results showed that BMSC-derived cell membrane vesicles possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental cells.
    [Bone Research]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    HWJMSC-EVs Promote Cartilage Regeneration and Repair via the ITGB1/TGF-β/Smad2/3 Axis Mediated by Microfractures

    Researchers verified whether MSC-derived extracellular vesicles promoted cartilage damage repair mediated by microfractures and to explore the repair mechanisms.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    POLE2 Promotes Osteosarcoma Progression by Enhancing the Stability of CD44

    The GSE14359 chip from the GEO database was used to screen differentially expressed genes in osteosarcoma (OS). DNA polymerase epsilon 2 (POLE2) was confirmed to overexpress in OS tissues and cell lines by immunohistochemical staining, qPCR, and Western blot.
    [Cell Death Discovery]

    Full Article

    Modulating the Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity

    The authors used an in vitro system to compare the priming of human MSCs by two inflammatory inducers TNF-α and CRX-527 on exosome molecular cargo, as well as on an in vivo rat ligament injury model to validate exosome potency.
    [Stem Cells]

    AbstractPress Release

    Comprehensive Assessment of Goat Adipose Tissue-Derived Mesenchymal Stem Cells Cultured in Different Media

    Scientists assessed the effects of four commonly used culture media on goat adipose tissue-derived MSC culture characteristics, stem cell-specific immunophenotype, and differentiation.
    [Scientific Reports]

    Full Article

    Mitochondrial Ca2+ Signaling Is a Hallmark of Specific Adipose Tissue-Cancer Crosstalk

    The authors showed that conditioned media derived from adipose tissue cultures enriched in precursor cells impinge on mitochondrial Ca2+ homeostasis of target cells.
    [Scientific Reports]

    Full Article

    Tailored Apoptotic Vesicles Promote Bone Regeneration by Releasing the Osteoinductive Brake

    Researchers compared MSCs, MSC derived apoptotic vesicles (MSC-apoVs), and MSC-exosomes from two types of MSC. They generated a map of miRNAs specific to MSC-apoVs and identified seven miRNAs specifically enriched in MSC-apoVs compared to MSCs and MSC-exosomes.
    [International Journal of Oral Science]

    Full Article

    ALPL Regulates Pro-Angiogenic Capacity of Mesenchymal Stem Cells through ATP-P2X7 Axis Controlled Exosomes Secretion

    Exosomes derived from normal and hypophosphatasia human bone marrow MSCs were isolated and identified by ultracentrifugation, transmission electron microscopy, and nanoparticle size measurement.
    [Journal of Nanobiotechnology]

    Full Article

    Effect of In Vivo Culture Conditions on the Proliferation and Differentiation of Rat Adipose-Derived Stromal Cells

    Scientists transplanted separated adipose-derived stromal cells into local subcutaneous adipose tissues of nude mice as an in vivo cell culture model.
    [Mechanisms of Ageing and Development]

    Abstract
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    REVIEWS

    The Dual Role of Mesenchymal Stem Cells in Apoptosis Regulation

    MSCs regulate apoptosis through multiple molecules and pathways, including three classical apoptotic signaling pathways and other pathways. The authors summarize the current evidence on the regulation of apoptosis by MSCs.
    [Cell Death & Disease]

    Full Article

    Mesenchymal Stem Cell Based Therapies for Uveitis: A Systematic Review of Preclinical Studies

    Investigators analyzed and critically appraised all preclinical studies using cell therapy or cell-derived extracellular vesicles for uveitis, and provided insight into mechanisms regulating ocular inflammation.
    [Eye]

    Abstract
    INDUSTRY AND POLICY NEWS

    NIH Awards UAMS Researchers $2.27 Million to Study Estrogen’s Role in Preventing Bone Loss

    Researchers at the University of Arkansas for Medical Sciences (UAMS) will use a $2.27 million grant from the NIH to answer key questions about the cellular mechanisms used by estrogen to prevent bone loss and osteoporosis.
    [University of Arkansas for Medical Sciences]

    Press Release
    FEATURED EVENT

    International Society for Extracellular Vesicles Annual Meeting 2024

    May 9 – 12, 2024
    Melbourne, Australia

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    JOB OPPORTUNITIES

    Senior Lead Scientist – Pediatric Cancers

    University of Dundee – Dundee, Scotland, United Kingdom

    Medicinal Chemist – Pediatric Cancers

    University of Dundee – Dundee, Scotland, United Kingdom

    Postdoctoral Scholar – Synthetic Extracellular Matrix

    University of Oregon – Eugene, Oregon, United States

    Cell Manufacturing Specialist – Cell Therapy

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Postdoctoral Fellow – Pathology

    The University of Hong Kong – Hong Kong, Hong Kong

    > See All Jobs

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