Mesenchymal Cell News Volume 16.15 | Apr 23 2024

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    2024-04-23 | MESCN 16.15


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 16.15 – 23 April, 2024
    TOP STORY

    Transcriptomic and Cellular Decoding of Scaffolds-Induced Suture Mesenchyme Regeneration

    Investigators’ data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.
    [International Journal Of Oral Science]

    Full Article
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    The IL-6 Signaling Pathway Contributes Critically to the Immunomodulatory Mechanism of Human Decidua-Derived Mesenchymal Stromal Cells

    Researchers found that knock-down IL-6 in decidua-derived MSCs reduced the expression of PD-L1 and PD-L2, which are known as classical immune checkpoint inhibitors.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Inhibition of the Galactosyltransferase C1GALT1 Reduces Osteosarcoma Cell Proliferation by Interfering with Erk Signaling and Cell Cycle Progression

    The authors screened for differentially expressed genes in osteosarcoma. They found that osteosarcoma cases could be divided into fair and poor survival groups based on gene expression profiles.
    [Cancer Gene Therapy]

    Full Article

    Transcriptome and Single-Cell Analysis Reveal Disulfidptosis-Related Modification Patterns of Tumor Microenvironment and Prognosis in Osteosarcoma

    Scientists investigated disulfidptosis-related modification patterns in osteosarcoma (OS) and their relationship with survival outcomes in patients with OS.
    [Scientific Reports]

    Full Article

    Mitochondrial Enzyme FAHD1 Reduces ROS in Osteosarcoma

    Researchers investigated the impact of overexpressing the mitochondrial enzyme Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) in human osteosarcoma epithelial cells in vitro.
    [Scientific Reports]

    Full Article

    Ohwia caudata Aqueous Extract Attenuates Senescence in Aging Adipose-Derived Mesenchymal Stem Cells

    Using 0.1 μM doxorubicin, scientists induced aging in human adipose-derived MSCs and evaluated whether various concentrations of O. caudata aqueous extract exhibited anti-aging effects on them.
    [Heliyon]

    Full Article

    Mesenchymal Stem Cells Derived-Exosomes Enhanced Amniotic Membrane Extract Promotes Corneal Keratocyte Proliferation

    Investigators evaluated the effects of both amniotic membrane extract and Wharton’s jelly MSC derived-exosomes, individually and together, on the proliferation of corneal keratocytes as well as their ability to promote in vitro cell migration, wound healing, and their impact on cellular morphology.
    [Biotechnology Progress]

    Abstract

    Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics

    The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.
    [Molecular Therapy]

    AbstractGraphical Abstract

    PPARγ Inhibition Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Fracture Healing

    Bone healing processes in the rat femur fracture model were recorded and assessed by radiographic methods on Weeks 8, 14, and 20 postoperation.
    [Journal Of Cellular Biochemistry]

    Abstract
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    REVIEWS

    Exosomes Derived from Mesenchymal Stem Cells in Diabetes and Diabetic Complications

    The authors outline the properties of mesenchymal stromal cell-derived exosomes, and provide a thorough summary of their biological functions and potential uses in diabetes and its related complications.
    [Cell Death & Disease]

    Full Article

    Mesenchymal Stem Cells as Therapeutic Vehicles for Glioma

    MSCs exhibit advantages for glioma therapy because of their ability to pass through the blood–brain barrier and migrate to tumor cells and their tolerance to the immune system.
    [Cancer Gene Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    NIH Grant Supports Additional Baby Metabolism Research

    A five-year, $2.5 million R01 grant from the National Institutes of Health will help East Carolina University faculty members continue research on ways to curb generational obesity.
    [East Carolina University]

    Press Release

    Monash Cord Blood Cell Therapy Research Recognised with Multiple Awards

    Congratulations to Dr. Lindsay Zhou on receiving the Perinatal Research Society Mont Liggins Award and the Cerebral Palsy Alliance Award from the Perinatal Society of Australia and New Zealand for his research on cord blood cell therapy.
    [Monash University]

    Full Article
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    JOB OPPORTUNITIES

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    City of Hope – Duarte, California, United States

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    University of Dundee – Dundee, Scotland, United Kingdom

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    The University of Hong Kong – Hong Kong, Hong Kong

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    University of Sydney – Sydney, Australia

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