CURRENT PUBLICATIONS A Nonviral Minicircle Vector for Deriving Human Induced Pluripotent Stem Cells Researchers use a single minicircle vector to generate transgene-free induced pluripotent stem cells from adult human adipose stem cells. [Nat Methods] Adipose Tissue is an Extramedullary Reservoir for Functional Hematopoietic Stem and Progenitor Cells Results provide compelling evidence that adipose tissue is a novel extramedullary tissue possessing phenotypic and functional hematopoietic stem and progenitor cells. [Blood] Human and Mouse Adipose-Derived Cells Support Feeder-Independent Induction of Pluripotent Stem Cells Adult human and mouse adipose-derived stem cells can be reprogrammed to induced pluripotent stem cells with substantially higher efficiencies than those reported for human and mouse fibroblasts. [Proc Natl Acad Sci U S A] In Vitro High-Capacity Assay to Quantify the Clonal Heterogeneity in Trilineage Potential of Mesenchymal Stem Cells Reveals a Complex Hierarchy of Lineage Commitment This research addresses a basic prerequisite to realize the therapeutic potential of mesenchymal stem cells (MSCs) by developing a novel high-capacity assay to quantify the clonal heterogeneity in potency that is inherent to MSC preparations. [Stem Cells] The Performance of Bone Marrow Mesenchymal Stem Cell – Implant Complexes Prepared by Cell Sheet Engineering Techniques Mesenchymal stem cell-implants possessing osteogenic and vascularization abilities can be produced using cell sheet engineering techniques in conjunction with routine implant materials, which provide a novel technology to modify the implant surface. [Biomaterials] A 3-D Cardiac Muscle Construct for Exploring Adult Marrow Stem Cell Based Myocardial Regeneration In order to overcome the inadequate and inconsistent differentiation of bone marrow stromal cells (BMSCs) and to explore adult stem cell based myocardial regeneration, researchers have developed an in vitro model of three-dimensional cardiac muscle using rat ventricular embryonic cardiomyocytes and BMSCs. [Biomaterials] The Insulin-Like Growth Factor-1 Binding Protein Acid-Labile Subunit Alters Mesenchymal Stromal Cell Fate To determine the relationship between IGF-1, the binding proteins that stabilize IGF-1 and bone marrow adiposity, researchers evaluated the adipogenic potential of marrow-derived mesenchymal stromal cells from mice with decreased serum IGF-1 due to knockdown of IGF-1 production by the liver or knock-out of the binding proteins. [J Biol Chem] Generation of Human Induced Pluripotent Stem Cells from Umbilical Cord Matrix and Amniotic Membrane Mesenchymal Cells Researchers report the efficient nuclear reprogramming using exogenous factors of mesenchymal cells from placental chorionic and amniotic membranes and the umbilical cord. [J Biol Chem] Chondrogenic Pre-Induction of Human Mesenchymal Stem Cells on Phase-Pure (Beta)-Tricalcium-Phosphate: Enhanced Bone Quality by Endochondral Heterotopic Bone Formation The aim of this study was to investigate whether resorbable phase-pure (beta)-tricalcium-phosphate can support heterotopic bone formation by mesenchymal stem cells comparable to partially resorbable hydroxyapatite/tricalcium-phosphate. [ Acta Biomater] Effects Of High Dose Chemotherapy On Bone Marrow Multipotent Mesenchymal Stromal Cells Isolated From Lymphoma Patients The results suggest that high-dose chemotherapy applied to lymphoma patients damaged mesenchymal stromal cells, which was demonstrated by their reduced clonogenic potential, doubling time and cell expansion rates when compared to controls. [Exp Hematol]
|