CURRENT PUBLICATIONS Bone Progenitor Dysfunction Induces Myelodysplasia and Secondary Leukaemia By examining how mesenchymal osteolineage cells modulate hematopoiesis, researchers show that deletion of Dicer1 specifically in mouse osteoprogenitors, but not in mature osteoblasts, disrupts the integrity of hematopoiesis. [Nature] Pleiotrophin Regulates the Expansion and Regeneration of Hematopoietic Stem Cells Researchers show that pleiotrophin, a neurite outgrowth factor with no known function in hematopoiesis, efficiently promotes hematopoietic stem cell (HSC) expansion in vitro and HSC regeneration in vivo. [Nat Med] Retinoic Acid Regulates Differentiation of the Secondary Heart Field and TGF(Beta)-Mediated Outflow Tract Septation Reduction of TGF(beta)2 gene dosage in the retinoic acid receptor-deficient background restores septation but does not rescue alignment defects, indicating that excess TGF(beta) causes septation defects. [Dev Cell] A Proto-Oncogene Bcl-6 is Upregulated in the Bone Marrow Microenvironment in Multiple Myeloma Cells Bcl-6 expression in multiple myeloma (MM) cells is modulated, at least in part, via JAK/STAT3 and canonical NF-(kappa)B pathways; and that targeting Bcl-6, either directly or via these cascades, inhibits MM cell growth in the bone marrow milieu. [Blood] Genetic Variations in the Heparanase Gene Associate with Increased Risk of Graft-Versus-Host Disease Following Allogeneic Stem Cell Transplantation: Effect of Discrepancy Between Recipients and Donors The present study indicates a highly significant correlation of HPSE gene SNPs rs4693608 and rs4364254 and their combination with the risk of developing acute graft-versus-host disease. [Blood] Bone Marrow Stromal Cells use TGF(beta) to Suppress Allergic Responses in a Mouse Model of Ragweed-Induced Asthma In this study, using a ragweed induced mouse asthma model, researchers studied if bone marrow stromal cells could be beneficial in an allergic, Th2-dominant environment. [Proc Natl Acad Sci U S A] Large-Scale Extraction and Characterization of CD271+ Multipotential Stromal Cells from Trabecular Bone in Health and Osteoarthritis: Implications for Bone Regeneration Strategies Based on Minimally-Cultured Multipotential Stromal Cells CD45lowCD271+ multipotential stromal cells (MSCs) are abundant in the trabecular bone cavity and indistinguishable from aspirated CD45lowCD271+ MSCs. [Arthritis Rheum] Mineralocorticoid Receptor Overexpression in Embryonic Stem Cell Derived Cardiomyocytes Increases Their Beating Frequency Researchers demonstrate that the amplification of mineralocorticoid receptor signaling in embryonic stem cell-derived cardiomyocytes has a major impact on cardiomyocyte contractile properties through an important remodeling of ion channel expression contributing to arrhythmias. [Cardiovasc Res] Derivation of Functional Smooth Muscle Cells from Multipotent Human Hair Follicle Mesenchymal Stem Cells Researchers investigated the potential of human hair follicle cells for multi-lineage differentiation and as a source of functional smooth muscle cells. [Tissue Eng Part A]
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