CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats Researchers developed a protocol to isolate human bone marrow-derived clonal mesenchymal stem cells from bone marrow aspirate and investigated the effects of these cells in rat models of mild and severe acute pancreatitis. [Gastroenterology] TNF-Alpha Respecifies Human Mesenchymal Stem Cells to a Neural Fate and Promotes Migration Toward Experimental Glioma Taken together, the results provide evidence that culture-expansion of human mesenchymal stem cells (hMSCs) in the presence of TNF-alpha triggers neural gene expression and functional capacities, which could improve the use of hMSCs in the treatment of neurological disorders including malignant gliomas. [Cell Death Differ] Zinc Finger Protein 467 is a Novel Regulator of Osteoblast and Adipocyte Commitment The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage. cDNA microarrays and quantitative real-time PCR were carried out in a differentiating mouse stromal osteoblastic cell line, Kusa 4b10, to identify gene targets of factors that stimulate osteoblast differentiation including parathyroid hormone and gp130-binding cytokines, oncostatin M and cardiotrophin-1. [J Biol Chem] Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells In order to assess the potential of dental pulp-derived mesenchymal stem cells (DPSC) and umbilical cord-derived mesenchymal stem cells (UCSC) in future clinical applications, it is essential to gain more insight into their differentiation capacity and to evaluate the tissues formed by these cells. In the present study, the morphological and ultrastructural characteristics of DPSC and UCSC induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. [Cells Tissues Organs] Pegylated TRAIL Retains Anti-Leukemic Cytotoxicity and Exhibits Improved Signal Transduction Activity with Respect to TRAIL To improve the pharmacokinetic profile of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), an N-terminal specific pegylation was performed to generate pegylated TRAIL (PEG-TRAIL). In in vitro experiments, researchers found that although PEG-TRAIL was slightly less efficient than recombinant TRAIL in promoting leukemic cell apoptosis, it showed an improved ability to promote migration of bone-marrow mesenchymal stem cells and to elicit the ERK1/2 intracellular signal transduction pathway. [Invest New Drugs] INDUSTRY NEWS UVA Researchers Developing Innovative Ways to Heal Severe Bone Fractures Through Combined Adult Stem Cell and Genetic Therapy Millions of Americans each year suffer broken bones, and a majority recover without complications. But as many as one in five bone fracture patients face prolonged and complicated treatments such as bone grafts, synthetic bone replacement and multiple surgeries – all resulting in risk of infection. With the help of a $100,000 grant from the Orthopaedic Research and Education Foundation, researchers are developing innovative ways to overcome these problems by harnessing the body’s own regenerative powers to restore lost bone by combining gene therapy and adult stem cell therapy. [University of Virginia Health System Press Release]
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EVENTS (Listed by Date) The American Society for Cell Biology 50th Annual Meeting December 11-15, 2010 Philadelphia, United States The 3rd Young Investigator Stem Cell Meeting December 14, 2010 Tel Aviv, Israel Pharmacology in Stem Cells Research and Regenerative Medicine December 17, 2010 London, United Kingdom The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine December 17-19, 2010 Guangzhou, China Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, D.C., United States Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States Stem Cell Research Forum of India 2nd Annual Meeting February 8-11, 2011 Bangalore, India 1st Annual Clinical Meeting of the Cell Society February 18-19, 2011 La Jolla, United States SMi Stem Cells 2011 – Innovation and Commercialisation February 23-24, 2011 London, United Kingdom Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture February 28-March 2, 2011 Munich, Germany 6th Annual Stem Cell Summit March 1, 2011 New York, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Stem Cells, Cancer and Metastasis March 6-11, 2011 Dillon, United States PITTCON Conference & Expo 2011 March 13-18, 2011 Atlanta, United States 15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications March 16-19, 2011 Hilton Head Island, United States StemCONN 11 March 22, 2011 Farmington, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom World Stem Cells & Regenerative Medicine Congress 2011 May 9-11, 2011 London, United Kingdom Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference June 7-10, 2011 Granada, Spain International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011) August 3-5, 2011 Singapore Adult MSC2011 Innovations in Cell-Based Regenerative Therapies August 22-24, 2011 Cleveland, United States Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics December 1-2, 2011 London, United Kingdom Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies) Lab Technologist – Tissue Culture (STEMCELL Technologies) Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Mesenchymal Cell News at no cost. Visit here to post your career opportunities.
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