SCIENCE NEWS New Test Announced for Major Killer of Lung Transplant Patients While the exact relationship between the mesenchymal stromal cells and bronchiolitis obliterans syndrome (BOS) remains unclear, doctors know that most of the cells originate with the donor and not the recipient. Researchers hope a new diagnostic tool they developed to predict BOS will allow doctors to intervene earlier and, ultimately, to provide life-saving treatments. [Press release from the University of Michigan Medical School discussing online prepublication in the American Journal of Respiratory and Critical Care Medicine]
|
|
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) CDK1-Dependent Phosphorylation of EZH2 Suppresses Methylation of H3K27 and Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells In human mesenchymal stem cells, activation of cyclin-dependent kinase 1 (CDK1) promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of enhancer of zeste homologue 2 (EZH2) at Thr 487. [Nat Cell Biol] Mesenchymal Stromal Cells in Bronchoalveolar Lavage as Predictors of Bronchiolitis Obliterans Syndrome In this study, researchers investigated the association of number of mesenchymal stromal cells in bronchoalveolar lavage fluid with development of bronchiolitis obliterans syndrome in human lung transplant recipients. [Am J Respir Crit Care Med] Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy Researchers have observed that gold nanorods have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. [Nano Lett] Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells on Polyhydroxyalkanoate (PHA) Scaffolds Coated with PHA Granule Binding Protein PhaP Fused with RGD Peptide Human bone marrow mesenchymal stem cells (hBMSCs) were inoculated on/in the scaffolds for formation of articular cartilages derived from chondrogenic differentiation of hBMSCs for cartilage tissue engineering. [ Biomaterials] The Metabolism of Human Mesenchymal Stem Cells During Proliferation and Differentiation The present investigation measured the oxygen consumption, glucose consumption and lactate production of human mesenchymal stem cells during proliferation and subsequent differentiation towards the osteogenic and chondrogenic lineages. [J Cell Physiol] Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers CD44, CD73, CD90, Ki67, CD105, and CD106 and negative for CD34 and CD45. [Stem Cells Dev] Mesenchymal Stem Cells Contribute to the Abnormal Bone Marrow Microenvironment in Patients with Chronic Idiopathic Neutropenia by Overproduction of Transforming Growth Factor-Beta1 In this study, researchers investigated the possible involvement of bone marrow (BM) mesenchymal stem cells (MSCs) in the pathophysiology of chronic idiopathic neutropenia by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic characteristics, the differentiation capacity, the potential to produce pro-inflammatory cytokines, and the ability to suppress T cell proliferation. [Stem Cells Dev] Human Mesenchymal Stem Cells Cultured with Salivary Gland Biopsies Adopt an Epithelial Phenotype Some reports indicated that mesenchymal stem cells (MSCs) possessed the potential to differentiate into epithelial cells. To test this hypothesis with human salivary gland epithelial cells, a coculture system containing two chambers separated by a polyester membrane was used to study the capacity of human MSCs to adopt an epithelial phenotype when cocultured with human salivary gland biopsies. [Stem Cells Dev]
|
| |
|