Reversal of Serological, Immunological and Histological Dysfunction in Systemic Lupus Erythematosus Mice by Long-Term Serial Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation In this study, the efficacy of human adipose tissue-derived mesenchymal stem cell transplantation in systemic lupus erythematosus was investigated and the optimal transplantation window of stem cells was determined either before or after disease onset. [Arthritis Rheum] Abstract MicroRNAs in the Regulation of Interfacial Behaviors of MSCs Cultured on Microgrooved Surface Pattern This study elucidated the important roles of miRNAs in the regulation processes of the microenvironment triggered cell behaviors, and provided clues for the PHA biomedical materials development. [Biomaterials] Abstract TGFß1 Contributes to Cardiomyogenic-Like Differentiation of Human Bone Marrow Mesenchymal Stem Cells The majority of the protocols for cardiomyocyte differentiation of mesenchymal stem cells use 5-azacytidine as an inducer. As transforming growth factor ß1 and 5-azacytidine share similar target signaling pathways, researchers examined whether transforming growth factor ß1 can play a role in cardiac differentiation process in human mesenchymal stem cell of bone marrow origin. [Int J Cardiol] Abstract Mesenchymal Stem Cell-Secreted Soluble Signaling Molecules Potentiate Tumor Growth In the present study, researchers investigate whether the physical presence or the continuous presence of mesenchymal stem cells is required for enhanced tumor growth. [Cell Cycle] Abstract Tumor-Conditioned Mesenchymal Stem Cells Display Hematopoietic Differentiation and Diminished Influx of Ca2+ In this study, researchers analyzed the interaction of bone marrow derived mesenchymal stem cells and cancer cells by cell-cell contact and transwell culture system. [Stem Cells Dev] Abstract Improved Mesenchymal Stem Cells Attachment and In Vitro Cartilage Tissue Formation on Chitosan-Modified Poly(L-lactide-co-epsilon-caprolactone) Scaffold A porous elastomeric poly L-lactide-co-e-caprolactone (PLCL) was generated and cross-linked at the surface to chitosan to improve its wettability. Human bone marrow derived mesenchymal stem cells attachment, morphological change, proliferation and in vitro cartilage tissue formation on the chitosan-modified PLCL scaffold was compared to the unmodified PLCL scaffold. [Tissue Eng Part A] Abstract Mesenchymal Stem Cells Attenuate Angiotensin II-Induced Aortic Aneurysm Growth in Apolipoprotein E-Deficient Mice To clarify whether mesenchymal stem cells (MSCs) might be useful for aortic aneurysm cell therapy, researchers examined the effect of MSCs on vascular smooth muscle cells and macrophages in vitro, on aortic tissue ex vivo, and on aorta in vivo. [J Vasc Surg] Abstract Exosomes from Ovarian Cancer Cells Induce Adipose Tissue-Derived Mesenchymal Stem Cells to Acquire the Physical and Functional Characteristics of Tumor-Supporting Myofibroblasts In the current study, researchers determined the biological effect of exosomes from two ovarian cancer cell lines (SK-OV-3 and OVCAR-3) on adipose tissue-derived mesenchymal stem cells. [Gynecol Oncol] Abstract Phenotypic Correction of Hemophilia A in Sheep by Postnatal Intraperitoneal Transplantation of FVIII-Expressing MSC This novel, non-ablative mesenchymal stem cell (MSC) transplantation was straightforward, safe, and converted life-threatening, debilitating hemophilia A to a moderate phenotype in a large animal model. [Exp Hematol] Abstract Exosomes from Breast Cancer Cells Can Convert Adipose Tissue-Derived Mesenchymal Stem Cells Into Myofibroblast-Like Cells In this study, researchers investigated the influence of tumor cell-derived exosomes on mesenchymal stem cells (MSCs) by treating adipose tissue-derived MSCs with breast cancer-derived exosomes. [Int J Oncol] Abstract |