Mesenchymal Cell News Volume 3.39 | Oct 4 2011

Mesenchymal Stem Cells Impair In Vivo T-Cell Priming by Dendritic Cells
Here researchers show that murine mesenchymal stem cells impair Toll-like receptor-4 induced activation of dendritic cells resulting in the inhibition of cytokines secretion, down-regulation of molecules involved in the migration to the lymph nodes, antigen presentation to CD4⁺ T cells, and cross-presentation to CD8⁺ T cells. [Proc Natl Acad Sci USA] Abstract

The Creation of an In Vitro Adipose Tissue that Contains a Vascular–Adipocyte Complex
The study describes the in vitro fabrication of a pre-vascularized adipose tissue entirely using a self-assembly approach. [Biomaterials] Abstract

Limbal Epithelial Stem/Progenitor Cells Attract Stromal Niche Cells by SDF-1/CXCR4 Signaling to Prevent Differentiation
Researchers have used collagenase digestion to isolate the entire limbal epithelial stem cells and subjacent mesenchymal cells, and researchers have demonstrated that their close association is crucial for promoting epithelial clonal growth, implying that the latter serves as niche cells. [Stem Cells] Abstract

Aire Controls Mesenchymal Stem Cell-Mediated Suppression in Chronic Colitis
Here researchers show that bone marrow-derived mesenchymal stem cells require the transcriptional regulator Aire to suppress T cell-mediated pathogenesis in a mouse model of chronic colitis. [Mol Ther] Abstract

Trichostatin A Promotes Cardiomyocyte Differentiation of Rat Mesenchymal Stem Cells After 5-Azacytidine Induction or During Co-Culture with Neonatal Cardiomyocytes via a Mechanism Independent of Histone Deacetylase Inhibition
The study was to investigate the effect of trichostatin A, a histone deacetylase inhibitor, on cardiac differentiation of bone marrow mesenchymal stem cells in vitro. [Cell Transplant] Abstract

Mechanical Regulation of GSK3β in Mesenchymal Stem Cells Is Dependent on Akt Serine-473 Phosphorylation via mTOR Complex 2
Researchers considered whether Akt was the mechanically activated kinase responsible for phosphorylation and inactivation of GSK3β in mesenchymal stem cells. [J Biol Chem] Abstract

Combination of Retinal Pigment Epithelium Cell-Conditioned Medium and Photoreceptor Outer Segments Stimulate Mesenchymal Stem Cell Differentiation Toward a Functional Retinal Pigment Epithelium Cell Phenotype
In this study, scientists investigated if the soluble factors from retinal pigment epithelium (RPE) cells and photoreceptor outer segments could differentiate bone marrow-derived mesenchymal stem cells into cells having a phenotype characteristic of RPE cells. [J Biol Chem] Abstract

The In Vitro and In Vivo Effects of Human Umbilical Cord Mesenchymal Stem Cells on the Growth of Breast Cancer Cells
The purpose of the study was to detect the effect and possible mechanism of human umbilical cord mesenchymal stem cells on the in vitro and in vivo growth of stem cells isolated from primary human breast cancer cells and cell lines MDA-MB-231 and MCF-7. [Breast Cancer Res Treat] Abstract

A Toxicity Study of Multiple-Administration Human Umbilical Cord Mesenchymal Stem Cells in Cynomolgus Monkeys
The study was designed to evaluate the overall toxicology of human umbilical cord mesenchymal stem cells in cynomolgus monkeys with repeated administration. [Stem Cells Dev] Abstract

Mesenchymal Stem Cells Inhibit Recruitment of Flowing Neutrophils and Lymphocytes by Endothelial Cells: Roles of Interleukin-6 and Transforming Growth Factor-β
Researchers examined the hypothesis that mesenchymal stem cells can modify the ability of endothelial cells to recruit neutrophils and lymphocytes. [Heart] Abstract

Cross-Talk Between Human Mesenchymal Stem/Progenitor Cells (MSCs) and Rat Hippocampal Slices in LPS-Stimulated Cocultures: The MSCs Are Activated to Secrete Prostaglandin E2
Here investigators show that mesenchymal stem cells suppress endotoxin-induced glial activation in organotypic hippocampal slice cultures. [J Neurochem] Abstract

Promising Results Using Adipose Derived Stem Cells in Patients with Idiopathic Pulmonary Fibrosis
Adistem Ltd. began a clinical trial at the end of 2009 into the safety/efficacy of delivering autologous adipose-derived stem cells into the fibrotic lungs of ill patients, can now report very promising results. [PR Web] Press Release

The Centre for Commercialization of Regenerative Medicine (CCRM): CCRM Announces Its Inaugural Board of Directors
The Centre for Commercialization of Regenerative Medicine (CCRM) is proud to announce its inaugural Board of Directors. [Reuters] Press Release

VistaGen Therapeutics Expands Key Stem Cell Technology Patent Estate Supporting Its Drug Rescue and Cell Therapy Programs
VistaGen Therapeutics, Inc. announces the issuance of two additional United States patents supporting its therapeutic and drug discovery programs. [VistaGen Therapeutics, Inc.] Press Release

Prominent Stem Cell Scientist to Relocate to UCSB from Britain
Pete Coffey will begin work as a full-time researcher at the University of California Santa Barbara (UCSB) in November. [University of California, Santa Barbara] Press Release

Mayo Clinic Spinoff Raising Fresh Capital for Stem Cell Development Product
A Mayo Clinic spinoff company that develops products related to stem cell research is raising fresh capital. [MedCity News] Press Release

International Society for Cellular Therapy (ISCT) Leads Roundtable with Major US Payors, Healthcare Providers and Industry to Initiate a Collaboration to Address Cell Therapy Product Reimbursement
In keeping with its mission to drive the commercialization of cell therapy products and advance global patient access, ISCT hosted its second event this year in its Commercial Development Series, this time focusing on the timely issue of reimbursement for cell therapy and regenerative medicine products in the US market. [International Society for Cellular Therapy, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

Postdoctoral Research Assistant Grade 7 (University of Oxford)

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