The Composition of the Mesenchymal Stromal Cell Compartment in Human Bone Marrow Changes During Development and Aging Researchers show that CD271 and CD146 define distinct colony-forming-unit-fibroblast containing mesenchymal stromal cell subpopulations. [Haematologica] Abstract Human Amniotic Fluid-Derived Mesenchymal Stem Cells As Therapeutic Vehicles: A Novel Approach For the Treatment of Bladder Cancer In this study, researchers document the great potential of amniotic fluid-derived mesenchymal stem cells as anti-cancer vehicles, implemented by the targeting of the tumor site and further facilitated by their high proliferation rate and expansion efficiency in culture. [Stem Cells Dev] Abstract Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis Researchers investigated whether the expression of scleraxis can lead to the direct commitment of mesenchymal stem cells into tendon progenitors. [Stem Cells Dev] Abstract Effects of Glucocorticoid Receptor siRNA Delivered by Poly Lactic-Co-Glycolic Acid (PLGA) Microparticles on Proliferation and Differentiation Capabilities of Human Mesenchymal Stromal Cells This study investigated the effects of the blockage of endogenous glucocorticoids using glucocorticoid receptor small interfering RNA (siRNA) delivered by biodegradable PLGA microparticles on proliferation and differentiation capabilities of human mesenchymal stem cells in vitro. [Tissue Eng Part A] Abstract Towards an In Vitro Vasculature: Differentiation of Mesenchymal Stromal Cells Within an Endothelial Cell-Seeded Modular Construct in a Microfluidic Flow Chamber Researchers suggest that mesenchymal stem cell embedded modules may be useful for the formation of functional vasculature in tissue engineered constructs. [Tissue Eng Part A] Abstract Pullulan Hydrogels Improve Mesenchymal Stem Cell Delivery into High-Oxidative-Stress Wounds Researchers show that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high-oxidative-stress environments. [Macromol Biosci] Abstract MRI of the Proximal Femur Predicts Marrow Cellularity and the Number of Mesenchymal Stem Cells The purpose of this study was to determine whether the marrow conversion index in MRI is related to the total number of mononuclear and mesenchymal stem cells in proximal femoral metaphysis of patients with hip osteoarthritis. [J Magn Reson Imaging] Abstract Age-Related Changes in Rat Bone-Marrow Mesenchymal Stem Cell Plasticity In this study, researchers demonstrated that the expression profile of stemness markers was altered in bone-marrow mesenchymal stem cells derived from old rats. [BMC Cell Biol] Abstract Imatinib Inhibits Proliferation of Human Mesenchymal Stem Cells and Promotes Early but Not Late Osteoblast Differentiation In Vitro In this study osteoblast differentiation was induced in human mesenchymal stem cells by treatment with bone morphogenetic protein 2 in vitro. [J Bone Miner Metab] Abstract Neurotrophin-3 Gene Modified Mesenchymal Stem Cells Promote Remyelination and Functional Recovery in the Demyelinated Spinal Cord of Rats Researchers show that implantation of neurotrophin-3 gene-modified mesenchymal stem cells via a recombinant adenoviral vector into a region of ethidium bromide-induced demyelination in the spinal cord resulted in significant improvement of locomotor function and restoration of electrophysiological properties in rats. [J Neurol Sci] Abstract |