Mesenchymal Cell News Volume 3.49 | Dec 13 2011

DPP Activates Integrin-Mediated Anchorage-Dependent Signals in Undifferentiated Mesenchymal Cells
Here, researchers demonstrate that the RGD domain in DPP can bind to integrins on the cell surface of undifferentiated mesenchymal stem cells and pulp cells. [J Biol Chem] Abstract

Quantification of Protein Isoforms in Mesenchymal Stem Cells by Reductive Dimethylation of Lysines in Intact Proteins
Researchers report the use of reductive dimethylation on intact proteins to quantitatively compare protein isoform expression in the nucleus and cytoplasm of mesenchymal stem cells and normal stroma. [Proteomics] Abstract

A Comparison of Human Smooth Muscle and Mesenchymal Stem Cells as Potential Cell Sources for Tissue Engineered Vascular Patches
In this study, researchers compared the ability of human aortic smooth muscle cells and human mesenchymal stem cells to form cell sheets on thermo-responsive poly(N-isopropylacrylamide) substrates. [Tissue Eng Part A] Abstract

Collagen Three-Dimensional Hydrogel Matrix Carrying Basic Fibroblast Growth Factor for the Cultivation of Mesenchymal Stem Cells and Osteogenic Differentiation
Here researchers cultured rat bone marrow-derived mesenchymal stem cells (MSCs) in collagen hydrogels containing varying concentrations of basic fibroblast growth factor (bFGF) to examine the effect of bFGF on MSC proliferation and osteogenic differentiation in three-dimensional culture. [Tissue Eng Part A] Abstract

Maintenance of hESCs in Media Conditioned by Human Mesenchymal Stem Cells Obviates the Requirement of Exogenous Basic Fibroblast Growth Factor Supplementation
Researchers hypothesize that human foreskin fibroblasts (HFFs) and human mesenchymal stem cells (MSCs) are likely to be functionally different and therefore the mechanisms by which HFF-conditioned media (CM) and MSC-CM support undifferentiated growth of hESCs may differ. [Tissue Eng Part C Methods] Abstract

Activated T Cells Modulate Immunosuppression by Embryonic- and Bone Marrow-Derived Mesenchymal Stromal Cells through a Feedback Mechanism
The ability to suppress the proliferation of anti-CD3/CD28-stimulated CD4⁺ T cells by human embryonic stem cell-mesenchymal stromal cells (MSCs) was compared with adult bone marrow-MSC and neonatal foreskin fibroblast. [Cytotherapy] Abstract

Modulation of Immune Response and T-Cell Regulation by Donor Adipose-Derived Stem Cells in a Rodent Hind-Limb Allotransplant Model
In this study, the authors investigated whether donor adipose-derived stem cells have immunomodulatory effects, such as regulation of T cells, modulation of related cytokines, and prolongation of composite tissue allotransplantation survival, in a rodent hind-limb model. [Plast Reconstr Surg] Abstract

The Antitumor Effect of Mesenchymal Stem Cells Transduced with a Lentiviral Vector Expressing Cytosine Deaminase in a Rat Glioma Model
The purpose of this study was to evaluate the antitumor effect of cytosine deaminase-expressing mesenchymal stem cells in a rat C6 glioma model. [J Cancer Res Clin Oncol] Abstract

Maryland Stem Cell Research Commission Issues Supplement to FY 2012 RFAs – Collaborative Research Opportunity with the California Institute for Regenerative Medicine
The Maryland Stem Cell Research Commission announced the second year of a pilot a program that provides an opportunity for collaboration with the California Institute for Regenerative Medicine. [Maryland Stem Cell Research Fund] Press Release

CIRM Approves $27 Million for Initiatives to Accelerate Promising Stem Cell Research Projects
The California Institute for Regenerative Medicine (CIRM) enhanced its efforts to proactively discover and fund innovative research and to provide continuous support to successful research programs, speeding the development of new stem cell-based therapies. [California Institute for Regenerative Medicine] Press Release

Collaboration Aimed at Automating Manufacturing of Regenerative Medicine Therapies
Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine is teaming up with North Carolina State University’s Edward P. Fitts Department of Industrial and Systems Engineering with the goal of applying the latest advances in industrial engineering to the new field of regenerative medicine. [Wake Forest Baptist Medical Center] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

Assistant Professor – Regenerative Medicine/Stem Cell Biology (University of Pennsylvania)

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