Mesenchymal Cell News Volume 4.01 | Jan 10 2012

Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Regulates Mesenchymal Stem Cells through Let-7f MicroRNA and Wnt/ß-Catenin Signaling
Results demonstrate that TIMP-1 is a direct regulator of human mesenchymal stem cell functions and reveal a regulatory network in which let-7f modulates Wnt/ß-catenin activity. [Proc Natl Acad Sci USA] Abstract

Isolation of the Multipotent Mesenchymal Stem Cell Subpopulation from Human Gingival Fibroblasts by Culturing on Chitosan Membranes
This study showed that chitosan membranes could be used for isolation of the spheroid forming subpopulation in human gingival fibroblasts that contained multipotent adult stem cells of which the number varied among donors and sites. [Biomaterials] Abstract

Bone Marrow- and Subcutaneous Adipose Tissue-Derived Mesenchymal Stem Cells: Differences and Similarities
In this study, bone marrow-MSC and F-MSC cultures from 43 adult donors were evaluated in successive passages for immunophenotype, secretion of VEGF, SDF1, MCP1, IL6 and TGFß1, frequency of colony-forming units, frequency of adipo- and osteo-progenitors, and for onset of in vitro replicative senescence. [Cell Cycle] Abstract

Bone Marrow Mesenchymal Stem Cells in Patients with Beta Thalassemia Major: Molecular Analyses with Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy Study as a Novel Method
This study aimed to investigate global structural and compositional changes in bone marrow mesenchymal stem cells (BM-MSCs) in ß-thalassemia major that may provide a basis in understanding hematopoetic stem cell (HSC)-MSC interactions in such a pathological bone marrow microenvironment. [Stem Cells Dev] Abstract

Argonaute2 Regulation for K⁺ Channel-Mediated Human Adipose Tissue-Derived Stromal Cells Self-Renewal and Survival in Nucleus
Investigators detected an active potassium (K)⁺ channel that plays a critical role in argonaute2-mediated adipose tissue-derived stromal cell self-renewal through the control of membrane potential during cell self-renewal and differentiation. [Stem Cells Dev] Abstract

Modulation of Stromal Cell-Derived Factor-1/CXC Chemokine Receptor 4 Axis Enhances rhBMP-2-Induced Ectopic Bone Formation
The present study is the first that provides evidence of the efficacy of AMD3100 and stromal cell-derived factor-1 treatment to stimulate trafficking of mesenchymal stem cells to an ectopic implant site, in order to ultimately enhance recombinant human bone morphogenetic protein-2 (rhBMP-2) induced long-term bone formation. [Tissue Eng Part A] Abstract

Human Adipose Tissue-Derived Stromal Cell Therapy Prevents Bone Loss in Ovariectomized Nude Mouse
Investigators studied the effects of cell therapy of human adipose tissue-derived stromal cell on ovariectomy-induced bone loss in T cell deficient nude mice. [Tissue Eng Part A] Abstract

Micromarrows-Three-Dimensional Co-Culture of Hematopoietic Stem Cells and Mesenchymal Stromal Cells
Herein scientists describe a novel high-throughput three-dimensional (3D) co-culture system where murine-derived hematopoietic stem cell can be cocultured with mesenchymal stem/stromal cells in 3D microaggregates-which they termed “micromarrows.” [Tissue Eng Part C Methods] Abstract

1,25-Dihydroxyvitamin D3 Treatment Delays Cellular Aging in Human Mesenchymal Stem Cells while Maintaining their Multipotent Capacity
Effects of 100 nM 1,25-dihydroxyvitamin D3 (1,25D3) on human mesenchymal stem cells were analyzed by cell proliferation and apoptosis assay, β-galactosidase staining, VDR and surface marker immunocytochemistry, and RT-PCR of 1,25D3-responsive, quiescence- and replicative senescence-associated genes. [PLoS One] Abstract

Salicylideneamino-2-Thiophenol Enhances Osteogenic Differentiation through the Activation of MAPK Pathways in Multipotent Bone Marrow Stem Cell
In this study, scientists investigated the effects of salicylideneamino-2-thiophenol on osteogenic differentiation of multipotent bone marrow stromal stem cells by alizarin red S staining for osteogenic differentiation, RT-PCR and western blot for alkaline phosphatase activity and signaling pathways, FACS analysis and immunofluorescence staining for CD44 and CD51 expression, and calcium assays and immunofluorescence staining for signaling pathways. [J Cell Biochem] Abstract

With $10 Million Grant, Norma Sue Kenyon, Ph.D., Aims to Develop Co-Transplant Criteria
Years ago, Norma Sue Kenyon, Ph.D. discovered that delivering mesenchymal stem cells intravenously during islet transplantation more than doubled islet function, enhanced islet survival and reversed rejection episodes. Now, armed with a new five-year, nearly $10 million grant from NIH, Kenyon is poised to reproduce those novel findings, this time with an eye on identifying the optimal source of mesenchymal stem cells and developing the protocols for enhancing and infusing them during and after islet cell transplants. [University of Miami Miller School of Medicine] Press Release

AlloCure’s Investigational Treatment for Acute Kidney Injury Receives Fast Track Designation by FDA
AlloCure, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to AC607, the company’s investigational treatment for acute kidney injury. [AlloCure, Inc.]
Press Release

Michelle Spence Named New AMGA Vice President of Public Policy
The American Medical Group Association (AMGA) announced that Michelle Spence is joining the organization as Vice President of Public Policy, effective immediately. [American Medical Group Association]
Press Release

FDA Warns About Stem Cell Claims
The Food and Drug Administration (FDA) cautions consumers to make sure that any stem cell treatment they are considering has been approved by FDA or is being studied under a clinical investigation that has been submitted to and allowed to proceed by FDA. [Food and Drug Administration, United States]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Molecular Medicine Tri-Conference 2012
February 19-23, 2012
San Francisco, United States

NEW The 2012 Stem Cell Discussion Forum
May 18, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

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Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Assistant Professor – Regenerative Medicine/Stem Cell Biology (University of Pennsylvania)

Postdoctoral Positions – Stem Cell Biology (Columbia University)

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