Mesenchymal Cell News Volume 4.11 | Mar 20 2012

Expression of XBP1s in Bone Marrow Stromal Cells Is Critical for Myeloma Cell Growth and Osteoclast Formation
Researchers demonstrated that X-box binding protein-1 (XBP1s) is induced in bone marrow stromal cells of the multiple myeloma microenvironment. [Blood] Abstract

Mesenchymal Stem Cells: A Double-Edged Sword in Regulating Immune Responses
Researchers’ previous studies have shown that mesenchymal stem cells (MSCs) can become highly immunosuppressive upon stimulation by inflammatory cytokines. Here, they show that MSCs can also enhance immune responses. [Cell Death Differ] Abstract

Native CD271⁺ Multipotential Stromal Cells (MSCs) Have a Transcript Profile Indicative of Multiple Fates with Prominent Osteogenic and Wnt Pathway Signaling Activity
Scientists aimed to clarify the nature of candidate bone marrow-MSCs by profiling transcripts that reflected different aspects of their putative in vivo functions. [Arthritis Rheum] Abstract

Derivation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Cultured on Synthetic Substrates
Researchers tested the hypothesis that induced pluripotent stem cells could be maintained in an undifferentiated state in a xeno-free culture system and subsequently be differentiated into mesenchymal stem cells. [Stem Cells] Abstract

In Vitro Anti-Myeloma Activity of TRAIL-Expressing Adipose-Derived Mesenchymal Stem Cells
Researchers explored whether adipose-derived mesenchymal stem cells, engineered to express the pro-apoptotic ligand TRAIL, kill multiple myeloma (MM) cells and migrate towards MM cells in vitro. [Br J Haematol] Abstract

Increased Differentiation Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Aquaporin-5 Deficiency
Researchers’ data implicate aquaporin-5 as a novel determinant of bone marrow-derived mesenchymal stem cell (BMMSC) differentiation and therefore a new molecular target for regulating BMMSC differentiation during tissue repair and regeneration. [Stem Cells Dev] Abstract

Structured Three-Dimensional Co-Culture of Mesenchymal Stem Cells with Meniscus Cells Promotes Meniscal Phenotype without Hypertrophy
Scientists tested the feasibility of using mesenchymal stem cells co-cultured with mature meniscal cells for meniscus tissue engineering. [Biotechnol Bioeng] Abstract

Differentiated Adipose-Derived Stem Cells Promote Myelination and Enhance Functional Recovery in a Rat Model of Chronic Denervation
Rat adipose-derived stem cells transdifferentiated into a Schwann cell phenotype cocultured with dorsal root ganglion neurons were shown to associate with neurites and to express myelin basic protein-positive myelin protein. [J Neurosci Res] Abstract

Neural-Differentiated Mesenchymal Stem Cells Incorporated into Muscle Stuffed Vein Scaffold Forms a Stable Living Nerve Conduit
Researchers fabricated an acellular muscle stuffed vein seeded with differentiated mesenchymal stem cells as a substitute for nerve autografts. [J Orthop Res] Abstract

Ottawa Researchers to Lead World-First Clinical Trial of Stem Cell Therapy for Septic Shock
A team of researchers from the Ottawa Hospital Research Institute and the University of Ottawa has been awarded $367,000 from the Canadian Institutes of Health Research and $75,000 from the Stem Cell Network to lead the first clinical trial in the world of a stem cell therapy for septic shock. [Ottawa Hospital Research Institute] Press Release

Washington Center for Pain Management Begins Enrollment in United States Stem Cell Therapy Study in Subjects with Chronic Back Pain
Washington Center for Pain Management is participating in a nationwide Food and Drug Administration-cleared adult stem cell study testing novel treatment for chronic low back pain and has enrolled its first patient. [PR Newswire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellow (University of Rochester Medical Center)

Postdoctoral Fellow (Erasmus MC)

Research Associate(s) (Imperial College London) 


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