Mesenchymal Cell News Volume 4.12 | Mar 27 2012

Conditioned Media from Mesenchymal Stem Cells Enhanced Bone Regeneration in Rat Calvarial Bone Defects
Researchers’ demonstrated that conditioned media from human bone-marrow-derived mesenchymal stem cells can regenerate bone through mobilization of endogenous stem cells. [Tissue Eng Part A] Abstract

Inflammation and TLR Ligation Differentially Affect the Osteogenic Potential of Human Mesenchymal Stromal Cells (MSC) Depending on Their Tissue Origin
Scientists hypothesized that an inflammatory environment and/or TLR ligation could affect the MSC differentiation potential. [Tissue Eng Part A] Abstract

Bi-Directional Exchange of Membrane Components Occurs during Co-Culture of Mesenchymal Stem Cells and Nucleus Pulposus Cells
This study highlights bi-directional intercellular transfer of membrane components as a possible mechanism of cellular communication between mesenchymal stem cells and nucleus pulposus cells. [PLoS One] Abstract

Differential Mechanical Response of Mesenchymal Stem Cells and Fibroblasts to Tumor-Secreted Soluble Factors
Researchers report that despite their initial similarities to fibroblasts, bone marrow-derived mesenchymal stem cells respond not only faster but also more dramatically to pro-migratory tumor-secreted soluble factors. [PLoS One] Abstract

Intraperitoneal but Not Intravenous Cryopreserved Mesenchymal Stromal Cells Home to the Inflamed Colon and Ameliorate Experimental Colitis
Researchers compared the homing and therapeutic action of cryopreserved subcutaneous adipose tissue and bone marrow-derived mesenchymal stromal cells in rats with trinitrobenzene sulfonic acid-induced colitis. [PLoS One] Abstract

Heterologous Mesenchymal Stem Cells Successfully Treat Femoral Pseudarthrosis in Rats
Scientists evaluated the effectiveness of treating pseudarthrosis in rats by using bone marrow cell suspensions or cultures of bone marrow mesenchymal stromal cells. [J Transl Med] Abstract

Responses of Human Adipose-Derived Mesenchymal Stem Cells to Chemical Microenvironment of the Intervertebral Disc
Researchers investigate the viability, proliferation and the expression of main matrix proteins of adipose-derived mesenchymal stem cells in the chemical microenvironment of intervertebral disc under normal and degeneration conditions. [J Transl Med] Abstract

Acetylcholine Induces Mesenchymal Stem Cell Migration via Ca²⁺/PKC/ERK1/2 Signal Pathway
Researchers found that acetylcholine induces mesenchymal stem cell migration via muscarinic acetylcholine receptors. [J Cell Biochem] Abstract

Procognia Announced that the Feasibility Stage of the Company’s Research in Cooperation with the Weizmann Institute of Science Has Been Successfully Completed
Procognia announced that the feasibility stage of their research, which focused on the glycosylation structures of stem cells, has been successfully completed. The research was designed to develop a platform that will significantly improve the ability to identify and develop unique stem cells for transplant and treatment. [Procognia Ltd.] Press Release

Vet-Stem Announces StemInsure: A Small Fat Sample Now, a Lifetime of Stem Cells Later
Vet-Stem announced the introduction of StemInsure. The StemInsure service provides banked stem cells that can be grown to supply a lifetime of stem cell therapy for dogs. [Vet-Stem, Inc.] Press Release

UC San Diego, Taiwan’s Academia Sinica to Collaborate on Research
University of California (UC) San Diego and Taiwan’s Academia Sinica have agreed to collaborate across a broad range of research areas. [University of California, San Diego] Press Release

UC Health’s Community Benefit Tops $3 Billion
For the first time, University of California (UC) Health has measured the collective impact it has in caring for uninsured patients, educating tomorrow’s health leaders and advancing science to tackle medicine’s toughest challenges. [University of California] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellow (Erasmus MC)

Research Associate(s) (Imperial College London) 

PhD Student (University of Liège) 

Postdoctoral Position (GENyO)

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