Mesenchymal Cell News Volume 4.20 | May 22 2012

Engineering Bone Tissue from Human Embryonic Stem Cells
Researchers showed that the cultivation of human embryonic stem cell-derived mesenchymal progenitors on three-dimensional osteoconductive scaffolds in bioreactors with medium perfusion leads to the formation of large and compact bone constructs. [Proc Natl Acad Sci USA] Abstract | Press Release

Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Induced by Acellular Cartilage Sheets
Researchers investigated whether acellular cartilage sheets possess a chondrogenic induction activity that may benefit cartilage engineering with multipotent stem cells. [Biomaterials] Abstract

PTH Induces Differentiation of Mesenchymal Stem Cells by Enhancing BMP Signaling
Researchers demonstrated that parathyroid hormone (PTH)‐enhancement of mesenchymal stromal/stem cell differentiation to the osteoblast lineage occurs through a PTH and lipoprotein receptor‐related protein 6 (LRP6) dependent pathway by endocytosis of LRP6/PTH1R complex, allowing enhancement of bone morphogenetic protein (BMP) signaling. [J Bone Miner Res] Abstract

A Thermosensitive Hydrogel Capable of Releasing bFGF for Enhanced Differentiation of Mesenchymal Stem Cell into Cardiomyocyte-Like Cells under Ischemic Conditions
A thermosensitive hydrogel capable of differentiating mesenchymal stem cells (MSCs) into cardiomyocyte-like cells was synthesized. Researchers demonstrated that this hydrogel may potentially be used to deliver MSCs into hearts for regeneration of heart tissue. [Biomacromolecules] Abstract

Macrophages and Mesenchymal Stromal Cells Support Survival and Proliferation of Multiple Myeloma Cells
Scientists investigated the proliferation of multiple myeloma tumor cell lines when cultured alone or together with mesenchymal stromal cells (MSCs), macrophages, or a combination of MSCs and macrophages, using the carboxyfluorescein succinimidyl ester assay. [Br J Haematol] Abstract

Bisphosphonate- and Statin-Induced Enhancement of OPG Expression and Inhibition of CD9, M-CSF, and RANKL Expressions via Inhibition of the Ras/Mitogen Activated Protein Kinase Kinase/Extracellular Signal Regulated Kinase Pathway and Activation of Mitogen Activated Protein Kinase p38 in Mouse Bone Marrow Stromal Cell Line ST2
Researchers investigated whether bisphosphonates and statins increase osteoprotegerin (OPG) expression and inhibit the expression of CD9, macrophage colony-stimulating factor (M-CSF), and receptor activator of the NF-κB ligand (RANKL) in the bone marrow-derived stromal cell line ST2. [Mol Cell Endocrinol] Abstract

Nanog Promotes Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2 by Modulating Bone Morphogenetic Protein Signaling
Researchers examined the effect of forced Nanog expression in mesenchymal cells, with a particular focus on osteogenic differentiation. [J Cell Physiol] Abstract

Evaluation of Methods for Cultivating Limbal Mesenchymal Stromal Cells
Scientists evaluated methods for culturing human limbal mesenchymal stromal cells. [Cytotherapy] Abstract

World’s First Approved Stem Cell Drug; Osiris Receives Marketing Clearance from Health Canada for Prochymal
Osiris Therapeutics Inc. announced it has received market authorization from Health Canada to market its stem cell therapy Prochymal^®, an intravenous formulation of mesenchymal stem cells, for the treatment of acute graft-vs-host disease in children. [Osiris Therapeutics Inc.] Press Release

Fibrocell Science Inc., Announces Exclusive License Agreement with UCLA on Dermal Cell Research to Advance the Development of Personalized Cell Therapies
Fibrocell Science, Inc. announced that it has signed an exclusive license agreement with The Regents of the University of California, under which it acquired the rights to commercially apply discoveries resulting from the scientific collaboration between the University of California, Los Angeles (UCLA) and Fibrocell Science, Inc. [Fibrocell Science, Inc.] Press Release

Tissue Engineering Expert Elected as Leader of International Scientific Society
Anthony Hollander, ARC Professor of Rheumatology and Tissue Engineering at the University of Bristol has been elected President of the International Cartilage Repair Society. [University of Bristol] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Conference: Mammary Gland Biology
June 10-15, 2012
Lucca, Italy

Visit our events page to see a complete list of events in the mesenchymal cell community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

PhD Student (University of Liège)

Postdoctoral Fellowship – Mesenchymal Stem Cell Biology (University of Connecticut Health Center)

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