Targeting Androgen Receptor in Bone Marrow Mesenchymal Stem Cells Leads to Better Transplantation Therapy Efficacy in Liver Cirrhosis Using two liver cirrhosis mouse models induced by CCl4 or TAA, the authors showed targeting androgen receptor in the bone marrow mesenchymal stem cells improves their self-renewal and migration potentials and increases paracrine effects to exert anti-inflammatory and anti-fibrotic actions to enhance liver repair. [Hepatology] Abstract Isolation of Mouse Mesenchymal Stem Cells on the Basis of Expression of Sca-1 and PDGFR-α Scientists described in detail their protocol to isolate platelet-derived growth factor receptor α (PDGFR-α)-positive and stem cell antigen 1 (Sca-1)-positive mesenchymal stem cells using flow cytometry. [Nat Protoc] Abstract The Impact of Cell Source, Culture Methodology, Culture Location and Individual Donors on Gene Expression Profiles of Bone Marrow-Derived and Adipose-Derived Stromal Cells Bone marrow stromal cells were collected from either human bone marrow or adipose tissue, and expanded using two different culture methods: one based on fetal calf serum, and one based on human platelet lysate. [Stem Cell Dev] Abstract Prospective Dual Role of Mesenchymal Stem Cells in Breast Tumor Microenvironment The interplay between the breast resident adipose tissue-derived mesenchymal stem cells (B-ASCs) and breast tumor microenvironment was studied. It was found that a distinct subset of B-ASCs display a strong affinity for conditioned media from two breast cancer cell lines, MDA-MB 231 and MCF-7. [Breast Cancer Res Treat] Abstract Pericyte-Like Progenitors Show High Immaturity and Engraftment Potential as Compared with Mesenchymal Stem Cells Mesenchymal stem cells (MSCs) and pericyte progenitors (PPs) are both perivascular cells with similar multipotential properties regardless of tissue of origin. Researchers compared the phenotype and function of the two cell types derived from the same bone-marrow samples but expanded in their respective media – pericyte conditions (endothelial cell growth medium 2) for PPs and standard medium (mesenchymal stem cell medium) for MSCs. [PLoS One] Full Article Differential Gene Expression Profile Associated with the Abnormality of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia Scientists comprehensively compared the biological features and gene expression profile of bone marrow mesenchymal stem cells between aplastic anemia patients and healthy volunteers. [PLoS One] Full Article Activation of Canonical Wnt Pathway Promotes Differentiation of Mouse Bone Marrow-Derived MSCs into Type II Alveolar Epithelial Cells, Confers Resistance to Oxidative Stress, and Promotes their Migration to Injured Lung Tissue In Vitro The authors investigated the role of the canonical wnt pathway in the differentiation of mouse bone marrow-derived mesenchymal stem cells (MSCs) into type II alveolar epithelial cells. [J Cell Physiol] Abstract Effects of Transplanted Bone-Marrow-Derived Mesenchymal Stem Cells in Animal Models of Acute Hepatitis Researchers aimed to evaluate the therapeutic effects of bone-marrow-derived mesenchymal stem cells on ConA-induced hepatitis and to elucidate the possible mechanism involved. [Cell Tissue Res] Abstract Dissecting the Impact of Frizzled Receptors in Wnt/β-Catenin Signaling of Human Mesenchymal Stem Cells For studying the functional relevance of Frizzled receptors in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in human mesenchymal stem cells carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). [Biol Chem] Abstract Long Term Effects of the Implantation of Wharton’s Jelly-Derived Mesenchymal Stem Cells from the Umbilical Cord for Newly-Onset Type 1 Diabetes Mellitus Researchers assessed the long-term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset Type 1 Diabetes Mellitus. [Endocr J] Abstract | Full Article |