Direct GSK-3β Inhibition Enhances Mesenchymal Stromal Cell Migration by Increasing Expression of Phospho-β-PAK-Interacting Exchange Factor and CXC Chemokine Receptor 4 Investigators assessed whether inhibition of glycogen synthase kinase-3β (GSK-3β) increases the migration capacity of mesenchymal stromal cells during ex vivo expansion. [Mol Neurobiol] Full Article Mesenchymal Stem Cells Prevent Hydrocephalus after Severe Intraventricular Hemorrhage Researchers determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage after severe intraventricular hemorrhage in newborn rats. [Stroke] Abstract Aging Bone Marrow Mesenchymal Stromal Cells Have Altered Membrane Glycerophospholipid Composition and Functionality The clinical use of human mesenchymal stem/stromal cells (MSCs) demands sequential cell expansions and since it is well established that membrane glycerophospholipids (GPLs) provide precursors for signaling lipids that modulate cellular functions, the authors studied the effect of the donor’s age and cell doublings on the GPL profile of human bone marrow MSC. [J Lipid Res] Abstract Human Mesenchymal Stem Cells Isolated from Olfactory Biopsies but Not Bone Enhance CNS Myelination In Vitro Scientists characterized, purified, and assessed the repair potential of human lamina propria mesenchymal-like stem cells by investigating their effect on glial cell biology with specific emphasis on CNS myelination in vitro. [Glia] Abstract PEP-1-CAT-Transduced Mesenchymal Stem Cells Acquire an Enhanced Viability and Promote Ischemia-Induced Angiogenesis Poor survival of mesenchymal stem cells (MSC) compromised the efficacy of stem cell therapy for ischemic diseases. Researchers investigated the role of PEP-1-CAT transduction in MSC survival and its effect on ischemia-induced angiogenesis. [PLoS One] Full Article Functional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells The authors aimed to determine to which degree in vitro aging and chronological aging may be similar processes or if in vitro culture-related changes at the cellular and molecular level are at least altered as a function of donor age. [PLoS One] Full Article Mesenchymal Stem Cells as an Appropriate Feeder Layer for Prolonged In Vitro Culture of Human Induced Pluripotent Stem Cells Because of some problems in the use of animal feeders and in order to simplify the therapeutic application of human induced pluripotent stem cells, investigators tested human adult bone marrow mesenchymal stem cells as a potent feeder system. [Mol Biol Rep] Full Article Effects of Glucocorticoid Receptor Antagonist, RU486, on the Proliferative and Differentiation Capabilities of Bone Marrow Mesenchymal Stromal Cells in Ovariectomized Rats Researchers investigated the effects mediated by endogenous glucocorticoids and the effects of an antagonist of the glucocorticoid receptor, RU486, on the proliferative and differentiation capabilities of mesenchymal stem/stromal cells using an ovariectomized animal model. [J Orthop Res] Abstract A Comparison of Allogeneic and Autologous Mesenchymal Stromal Cells and Osteoprogenitor Cells in Augmenting Bone Formation around Massive Bone Tumor Prostheses The authors investigated the hypothesis that allogeneic mesenchymal stromal cells and osteoprogenitor cells will augment bone growth equally when compared with autologous bone marrow stem cells. [J Biomed Mater Res A] Abstract |