Mesenchymal Cell News Volume 5.41 | Oct 22 2013

Hypoxia, Leptin and VEGF Stimulate Vascular Endothelial Cell Differentiation of Human Adipose Tissue-Derived Stem Cells
Human adipose tissue derived stem cells (hASCs) differentiated into adipocytes after cultivation in adipogenic medium. Exposure of hASCs for 10 days under hypoxia in combination with leptin increased the percentage of CD31+ endothelial cells as well as CD31, VE-Cadherin, Flk-1, Tie2, von Willebrand factor and endothelial cell nitric oxide synthase mRNA expression. [Stem Cells Dev] Abstract

miR-27 Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-Derived Stem Cells
Scientists identified that the levels of both microRNA (miR)-27a and miR-27b were downregulated following adipogenic induction of human adipose-derived stem cells, while the mRNA level of prohibitin was upregulated. [J Biol Chem] Abstract | Full Article

Inhibitory Effect and Mechanism of Mesenchymal Stem Cells on Liver Cancer Cells
Scientists investigated the inhibitory effect and mechanism of mesenchymal stem cells (MSCs) on human hepatoma HepG₂ cells using co-culture and conditioned medium system and animal transplantation model. The HepG₂ cells were co-cultured with MSCs or treated with conditional media derived from MSCs cultures in vitro. [Tumor Biol] Abstract

Silica Coating of the Pore Walls of a Microporous Polycaprolactone Membrane to be Used in Bone Tissue Engineering
Researchers showed that silica forms a thin coating layer homogeneously distributed over the pore walls when sol-gel reaction is catalyzed by hydrochloric acid, while it forms submicron spherical particles when using basic catalyzer. Some physical properties and the viability and osteoblastic differentiation of bone marrow rat mesenchymal stem cells cultured on pure and hybrid membranes were studied. [J Biomed Mater Res A] Abstract

Chondrogenic Potential of Stem Cells Derived from Adipose Tissue: A Powerful Pharmacological Tool
Scientists characterized the chondrogenic potential of human Multipotent Adipose-Derived Stem (hMADS) cells, and their potential use as pharmacological tool. hMADS cells are able to synthesize matrix proteins including COMP, Aggrecan and type II Collagen. [Biochem Biophys Res Commun] Abstract

Pollen-Induced Antigen Presentation by Mesenchymal Stem Cells and T Cells from Allergic Rhinitis
Researchers investigated the immune effects of mesenchymal stem cells (MSCs) on allergen-stimulated lymphocytes from allergic rhinitis (AR) subjects. In contrast to subjects with allergic asthma, MSCs caused a significant increase in the proliferation of antigen-challenged lymphocytes from AR subjects. [Clin Transl Immunol] Full Article

Human Bone Marrow Mesenchymal Stem Cells Regulate Biased DNA Segregation in Response to Cell Adhesion Asymmetry
Researchers investigated cell adhesion geometries as a potential parameter by plating human mesenchymal stem cells from healthy donors on fibronectin-coated micropatterns. [Cell Rep]
Full Article | Graphical Abstract

Lysophosphatidic Acid Protects Human Mesenchymal Stromal Cells from Differentiation-Dependent Vulnerability to Apoptosis
Scientists examined the ability of lysophosphatidic acid to abrogate serum deprivation and hypoxia-induced apoptosis in human mesenchymal stromal cells (MSC) at increasing stages of osteogenic differentiation in vitro and assessed MSC survival in vivo. [Tissue Eng Part A] Abstract

GFOGER-Modified MMP-Sensitive Polyethylene Glycol (PEG) Hydrogels Induce Chondrogenic Differentiation of Human Mesenchymal Stem Cells
Interactions of human mesenchymal stem cells (hMSCs) with the triple helical collagen mimetic, GPC(GPP)5-GFOGER-(GPP)5GPC-NH2, and the fibronectin adhesion peptide, RGD, were studied in degradable or non-degradable PEG gels formed by Michael-type addition chemistry. [Tissue Eng Part A] Abstract

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New Jersey Health Foundation Awards $50,000 Grant for Research to Facilitate Stem Cell Growth
Dr. Steven Levison has received a $50,000 Innovation Stage Funding Grant from New Jersey Health Foundation to advance research that could make stem cell growth easier and less expensive for researchers, scientists and others interested in using stem cells to advance medical studies. [PR Newswire Association LLC] Press Release

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PhD Student Position – Pro-Tumorigenic Effect of Mesenchymal Stem Cells in Brain Tumors (Ludwig Maximilian University Munich)

Postdoctoral Fellow – Adipose Mesenchymal Stem Cells For Retinal Disease (University of Virginia)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

9 PhD Positions and 1 Postdoctoral Position – Tissue Engineering and Regenerative Medicine (RUNMC)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Position – Cell Delivery Systems in Bone Repair (Fujifilm)

PhD Position – Biomaterial Imaging (Uppsala University)

Principal Investigator – Developmental & Stem Cell Biology (SickKids Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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