A Set of MicroRNAs Mediate Direct Conversion of Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells into Hepatocytes Scientists aimed to clarify the instructive role of six overexpressed microRNAs (miRNAs) during hepatic differentiation of human umbilical cord lining-derived mesenchymal stem cells (hMSCs) and to test whether overexpression of any of these miRNAs is sufficient to induce differentiation of the hMSCs into hepatocyte-like cells. [Cell Death Dis] Full Article Hypoxic Mesenchymal Stem Cells Engraft and Ameliorate Limb Ischaemia in Allogeneic Recipients Researchers demonstrated that hypoxic mesenchymal stem cells have an increased ability to engraft in allogeneic recipients by reducing NK cytotoxicity, and decrease the accumulation of host-derived NK cells when transplanted in vivo. [Cardiovascular Res] Abstract Silk Fibroin Based Complex Particles with Bioactive Encrustation for BMP-2 Delivery Pure silk fibroin particles and particles with calcium carbonate encrustation were designed, developed and functionalized by bone morphogenetic protein 2 (BMP-2). These were used to deliver the bioactive molecule to mesenchymal stem cells and induce osteogenic differentiation. [Biomacromolecules] Abstract Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal®) as a Rescue Agent for Severe Refractory Acute GvHD in Pediatric Patients Investigators evaluated the risk/benefit profile of remestemcel-L, a third party, off-the-shelf source of human mesenchymal stem cells, as a rescue agent for treatment-resistant acute graft versus host disease (GvHD) in pediatric patients. [Biol Blood Marrow Transplant] Abstract | Press Release Canonical Wnt Signaling Differently Modulates Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow and from Periodontal Ligament under Inflammatory Conditions Periodontal ligament stem cells (PDLSCs) exhibit weaker adipogenic and osteogenic differentiation capacities compared to bone marrow derived mesenchymal stem cells (BMMSCs). TNF-α inhibited osteogenic differentiation of PDLSCs more than BMMSCs mainly through regulating canonical Wnt pathway. [Biochim Biophys Acta] Abstract Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation for Periodontal Regeneration Researchers investigated the possibility of using local administration of allogeneic bone marrow mesenchymal stem cells to induce tissue regeneration in periodontal defects in a rat model of periodontitis. [J Dent Res] Abstract Enrichment Isolation of Adipose-Derived Stem/Stromal Cells from the Liquid Portion of Liposuction Aspirates with the Use of an Adherent Column Investigators evaluated the effectiveness of an adherent column, currently used to isolate mesenchymal stromal cells from bone marrow, to isolate liposuction aspirate fluid cells. [Cytotherapy] Abstract Detection of Spontaneous Tumorigenic Transformation during Culture Expansion of Human Mesenchymal Stromal Cells Mesenchymal stem/stromal cell cultures derived from bone marrow and liver were evaluated for the presence of aberrant cells following long-term expansion. [Exp Biol Med] Abstract Novel Biologically-Inspired Rosette Nanotube PLLA Scaffolds for Improving Human Mesenchymal Stem Cell Chondrogenic Differentiation Scientists designed a novel tissue engineered nanostructured cartilage scaffold via biologically-inspired self-assembling rosette nanotubes and biocompatible non-woven poly (l-lactic acid) (PLLA) for enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation. [Biomed Mater] Abstract Mesenchymal Stem Cell-Conditioned Medium Enhances Osteogenic and Chondrogenic Differentiation of Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells by Mesodermal Lineage Induction Scientists hypothesized that treatment of embryoid bodies composed of either human embryonic stem cells or human induced pluripotent stem cells with human mesenchymal stem cells-conditioned medium can stimulate the induction of the mesodermal lineage and subsequent differentiation toward the osteogenic and chondrogenic lineage. [Tissue Eng Part A] Abstract Poly(Epsilon-Lysine) Dendrons Tethered with Phosphoserine Increase Mesenchymal Stem Cell Differentiation Potential of Calcium Phosphate Gels Cytotoxicity tests on osteoblast-like MG-63 cells as well as morphology and viability studies showed that dendrons induced a significantly higher levels of cell proliferation at early incubation time. Differentiation of the cell was also clearly enhanced at longer incubation time as demonstrated by both alkaline phosphatase activity and expression of typical markers. [Tissue Eng Part A] Abstract |