Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice Scientists determined if microvesicles released by human bone marrow derived mesenchymal stem cells would be effective in restoring lung protein permeability and reducing inflammation in E. coli endotoxin-induced acute lung injury in C57BL/6 mice. [Stem Cells] Abstract | Full Article Nanotubular Crosstalk with Distressed Cardiomyocytes Stimulates the Paracrine Repair Function of Mesenchymal Stem Cells Researchers addressed whether cell-to-cell communication processes between mesenchymal stem cells (MSC) and suffering cardiomyocytes and more particularly those involving tunneling nanotubes control the MSC paracrine regenerative function. [Stem Cells] Abstract | Full Article Rescue of Proinflammatory Cytokine-Inhibited Chondrogenesis by the Antiarthritic Effect of Melatonin in Synovium Mesenchymal Stem Cells via Suppression of Reactive Oxygen Species and Matrix Metalloproteinases Scientists investigated the anti-inflammatory and chondroprotective effects of melatonin on human mesenchymal stem cells (MSCs) in a proinflammatory cytokine-induced arthritic environment. MSCs were induced toward chondrogenesis in the presence of interleukin-1ß or tumor necrosis factor a with or without melatonin. [Free Radic Biol Med] Abstract Semaphorin 3A Induces Mesenchymal Stem-Like Properties in Human Periodontal Ligament Cells Researchers showed that Semaphorin 3A can induce mesenchymal stem-like properties in human periodontal ligament cells. [Stem Cells Dev] Abstract Tumor Necrosis Factor-a/CD40 Ligand Engineered Mesenchymal Stem Cells Greatly Enhanced the Anti-Tumor Immune Response and Lifespan in Mice Both dendritic cells (DCs) and mesenchymal stem cells (MSCs) were isolated from BALB/c mice. DCs were then co-cultured with (tumor necrosis factor-a (TNF-a) and/or CD40 Ligand (CD40L))-transduced MSCs. The longest mice survival was observed in mice groups that were administred with DCs plus (TNF-a/CD40L)-MSCs.[Human Gene Ther] Abstract Protective Effects of Mesenchymal Stem Cells with CXCR4 Up-Regulation in a Rat Renal Transplantation Model Scientists investigated chemokine receptor 4 (CXCR4) expression in MSCs and to validate both its role in mediating migration to transplanted kidneys and its immunoregulatory effects in renal protection. [PLoS One] Full Article Retinoic Acid Remodels Extracellular Matrix (ECM) of Cultured Human Fetal Palate Mesenchymal Cells (hFPMCs) through Down-Regulation of TGF-ß/Smad Signaling Researchers explored the effect of retinoic acid (RA) overexposure on ECM and the probable mechanisms in hFPMCs. RA dose-dependently inhibited cell proliferation and mRNA and protein levels of ECM components fibronectin, tenascin C and fibrillin-2. [Toxicol Lett] Abstract Mesenchymal Derivatives of Genetically Unstable Human Embryonic Stem Cells Are Maintained Unstable but Undergo Senescence in Culture as Do Bone Marrow-Derived Mesenchymal Stem Cells Scientists report that the human embryonic stem cell lines HUES-7 and -9 carrying multiple chromosomal alterations produce in vitro mesenchymal stem cells that show progressive growth arrest and enter senescence after 15 and 16 passages, respectively. [Cell Reprogram] Abstract Humanized Culture of Periosteal Progenitors in Allogeneic Serum Enhances Osteogenic Differentiation and In Vivo Bone Formation STAT3 phosphorylation was enhanced in human allogeneic serum (hAS)-cultured human periosteum derived cells, inhibition of which ablated the proliferative effect of hAS. Furthermore, following in vivo implantation of hAS-cultured cells on NuOss scaffolds, enhanced bone formation was observed compared with fetal bovine serum. [Stem Cells Transl Med] Abstract Manipulation of Cell Sorting within Mesenchymal Stromal Cell-Islet Cell Multicellular Spheroids Scientists attempted to co-localize mesenchymal stromal cells (MSCs) with islets by creating single-celled suspensions of MSCs and cells from dissociated islets on top of arrays of round bottom wells. [Tissue Eng Part A] Abstract |