Mesenchymal Cell News Volume 6.06 | Feb18 2014

Extracellular Calcium and CaSR Drive Osteoinduction in Mesenchymal Stromal Cells
The authors evaluated the roles of extracellular calcium ([Ca²⁺]_o) and calcium sensing receptor (CaSR) in osteoinduction. Rat bone marrow mesenchymal stromal cells were stimulated with 10 mM of Ca²⁺. Several experiments were conducted to demonstrate the effect of [Ca²⁺]_o on chemotaxis, proliferation and differentiation to the osteoblastic lineage. [Acta Biomater] Abstract

Reprogramming to a Pluripotent State Modifies Mesenchymal Stem Cell Resistance to Oxidative Stress
Researchers compared the response of induced pluripotent stem cells generated from menstrual blood-derived mesenchymal stem cells, embryonic stem cells and adult menstrual blood-derived mesenchymal stem cells to reactive oxygen exposure and investigate the effects of reprogramming on cellular oxidative stress. [J Cell Mol Med] Full Article

Mesenchymal Stem Cells Recruited by Active TGFβ Contribute to Osteogenic Vascular Calcification
Scientists used a low-density lipoprotein receptor-deficient mouse model, which develop progressively arterial calcification after fed high-fat Western diets, to examine whether TGFβ is involved in the mobilization of mesenchymal stem cells during vascular calcification. [Stem Cells Dev] Abstract

Transplantation of Bone Marrow Mesenchymal Stem Cells Decreases Oxidative Stress, Apoptosis, and Hippocampal Damage in Brain of a Spontaneous Stroke Model
The authors aimed to evaluate whether mesenchymal stem cells (MSCs) decrease apoptotic death and oxidative stress in existing stroke-prone spontaneously hypertensive rat brain tissue. The results of qRT-PCR assays showed higher levels of the antiapoptotic Bcl-2 gene in the MSC-treated animals, compared with untreated. [Free Radic Biol Med] Full Article

Mesenchymal Stem Cell Injection Protects against Oxidative Stress in Escherichia coli-Induced Acute Lung Injury in Mice
Investigators hypothesized that intravenous injection of bone marrow-derived mesenchymal stem cells (MSCs) could attenuate Escherichia coli-induced acute lung injury (ALI) in mice by controlling the oxidative stress status. Pre- and post-injury MSC injection increased survival, reduced pulmonary edema and attenuated lung injuries in ALI mice. [Cytotherapy] Abstract

The Involvement of CXCL11 in Bone Marrow-Derived Mesenchymal Stem Cell Migration through Human Brain Microvascular Endothelial Cells
Scientists modeled the interactions between human mesenchymal stem cells (hMSCs) and human brain microvascular endothelial cells (HBMECs) to mimic the blood-brain barrier microenvironment. Real-time PCR analysis indicated that the chemokine CXCL11 is produced by hMSCs and the chemokine receptor CXCR3 is expressed on HBMECs. [Neurochem Res] Abstract

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Cells of Origin in Osteosarcoma: Mesenchymal Stem Cells or Osteoblast Committed Cells?
As more information is gathered regarding osteosarcoma initiating cells and how they may relate to the cell of origin researchers will derive a better understanding of the development of osteosarcoma which may ultimately lead to clinical improvements through more personalized therapeutic approaches. [Bone] Abstract

Mesenchymal Stem Cell Trials for Pulmonary Diseases
This mini-review summarizes ongoing clinical trials using mesenchymal stem/stromal cells (MSC) in lung diseases, critically examine the data supporting their use for this purpose, and discuss the next steps in the translational pathway for MSC therapy of lung diseases. [J Cell Biochem] Abstract

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Parcell Laboratories Promotes Colin White, Ph.D., to Chief Scientific Officer
Parcell Laboratories, Inc., developer of novel therapeutics based on its patented adult stem cell platform technology, the ELA® cell, has promoted Colin White, Ph.D., to the newly-created position of chief scientific officer. [Marketwire L.P.] Press Release

Ampio Announces Positive Preliminary Biochemical Findings from the Synovial Fluid of the Knees Treated in the SPRING Study
Ampio Pharmaceuticals, Inc. announced preliminary biochemical analysis of samples of synovial fluid drawn from the index knee (treated knee) of a subset of patients who participated in the SPRING study. This synovial analysis, suggested by the FDA, tests the change in expression of signaling and structural proteins that arise from the treatment of the knee with either AmpionTM or the saline vehicle control. [Ampio Pharmaceuticals Inc.] Press Release

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NEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

NEW Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Associate/Full Professor – Cardiovascular, Pulmonary, Neural Tissue Engineering/Regenerative Medicine (Temple University)

Postdoctoral Fellow – Regenerative Biology (University of California San Francisco)

Research Fellow – Mesenchymal Stem/Stromal Cell Biology (DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH)

Postdoctoral Researcher Position – Role of Muscle Stem Cells in Tissue Regeneration after Radiation Injury (IRSN [French Nuclear Safety Institute])

Postdoctoral Position – Regenerative Medicine (Centro Cardiologico Monzino IRCCS)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

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