Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation In Vitro Scientists provide a direct in vitro comparison of the osteogenic differentiation process in mesenchymal stem cells and induced pluripotent stem cells from adult C57BL/6J mice. [Stem Cells Dev] Abstract Functional Comparison of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Cells and Bone Marrow-Derived Mesenchymal Stromal Cells from the Same Donor Scientists have derived mesenchymal stem cell-like cells (iMPCs) using four different methodologies from a newly established induced pluripotent stem cell line reprogrammed from human bone marrow stromal cells (BMSCs), and compared the iMPCs directly to the originating parental BMSCs. [Stem Cells Dev] Abstract Development of a Dynamic Stem Cell Culture Platform for Mesenchymal Stem Cell Adhesion and Evaluation The authors have developed a device, the dynamic stem cell culture platform, consisting of a biomimetic scaffold cultured within the dynamic environment of a perfusion bioreactor. By varying scaffold parameters including stiffness and protein inclusion at the material surface, they found that mesenchymal stem cells were able to adhere to modified substrates, while still maintaining multipotency. [Mol Pharm] Abstract Growth Differentiation Factor 6 and Transforming Growth Factor-Beta Differentially Mediate Mesenchymal Stem Cell Differentiation, Composition and Micromechanical Properties of Nucleus Pulposus Constructs Researchers investigated the effect of growth differentiation factor-6, compared to other transforming growth factor superfamily members, on discogenic differentiation of mesenchymal stem cells, the matrix composition and micromechanics of engineered nucleus pulposus tissue constructs. [Arthritis Res Ther] Abstract | Full Article Nanotopography Directs Mesenchymal Stem Cells to Osteoblast Lineage through Regulation of MicroRNA-SMAD-BMP-2 Circuit Researchers investigated if chemically produced nanotopography on titanium surface induces osteoblast differentiation of cultured human bone marrow mesenchymal stem cells by regulating the expression of microRNAs. [J Cell Physiol] Abstract Mesenchymal Stem Cell or Chondrocyte Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering Researchers tested the use of mesenchymal stromal/stem cell- or chondrocyte laden microcarriers as building blocks for engineered cartilage tissue. [Tissue Eng Part A] Abstract Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels Investigators focused on mesenchymal stem cells immobilized in alginate hydrogels, and used immunohistochemistry and gene expression analysis combined with advanced microscopy techniques to describe properties of cells and distribution and organization of the forming extracellular matrix. [PLoS One] Full Article Cell-Autonomous Heparanase Modulates Self-Renewal and Migration in Bone Marrow-Derived Mesenchymal Stem Cells Scientists inhibited the enzymatic activity of cell-autonomous heparanase (HPSE1) in bone marrow-derived mesenchymal stem cells to clarify the physiological role of HPSE1 in bone marrow-derived mesenchymal stem cells. [J Biomed Sci] Abstract IKVAV Regulates ERK1/2 and Akt Signaling Pathways in BMMSC Population Growth and Proliferation The molecular mechanism of bone marrow mesenchymal stem cell (BMMSC) population growth and proliferation, induced by Isoleucyl-lysyl-valyl-alanyl-valine (IKVAV), was explored in this study. [Cell Prolif] Full Article Cell-Penetrating Peptide (CPP)-Conjugated Proteins Is an Efficient Tool for Manipulation of Human Mesenchymal Stromal Cells Researchers performed a comparison study of CPP-conjugated protein delivery systems using seven arginine and Streptolysin O-mediated systems. [Sci Rep] Full Article |