Additional Benefit of Combined Therapy with Melatonin and Apoptotic Adipose-Derived Mesenchymal Stem Cells against Sepsis-Induced Kidney Injury Researchers tested whether combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cells offered additional benefit in ameliorating sepsis-induced acute kidney injury. [J Pineal Res] Abstract Substrate Topography Determines the Fate of Chondrogenesis from Human Mesenchymal Stem Cells Resulting in Specific Cartilage Phenotype Formation The effects of chondroitin sulfate-coated nano-topographies on cell characteristics and chondrogenic differentiation of human mesenchymal stem cell (MSC) were investigated. Scientists showed that various nano-topographical patterns triggered changes in MSC morphology and cytoskeletal structure, affecting cell aggregation and differentiation. [Nanomedicine] Abstract Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-ß Expression and Secretion Scientists examined the roles of transforming growth factor (TGF)-ß in the AGE-induced suppression of mineralization of ST2 cells and human mesenchymal stem cells. AGE3 significantly inhibited mineralization in both cell types, whereas transfection with siRNA for the receptor for AGEs significantly recovered this process in ST2 cells. [Endocrinology] Abstract Donor-Matched Mesenchymal Stem Cells from Knee Infrapatellar and Subcutaneous Adipose Tissue of Osteoarthritic Donors Display Differential Chondrogenic and Osteogenic Commitment Researchers performed a donor-matched comparison between infrapatellar fat pad mesenchymal stem cells and knee subcutaneous adipose tissue stem cells, as appealing candidates for cell-based therapies that are easily accessible during surgery. [Eur Cell Mater] Abstract | Full Article Enhanced Chondrogenic Differentiation of Dental Pulp Stem Cells Using Nanopatterned PEG-GelMA-HA Hydrogels Researchers demonstrated that dental pulp stem cells formed three-dimensional spheroids, which provide an appropriate environment for in vitro chondrogenic differentiation. [Tissue Eng Part A] Abstract Distal-Less Homeobox 2 Promotes the Osteogenic Differentiation Potential of Stem Cells from Apical Papilla Scientists investigated distal-less homeobox 2 (DLX2) function in stem cells from apical papilla (SCAPs). They found that, in vitro, DLX2 expression was up-regulated in SCAPs by adding BMP4 and by inducing osteogenesis. [Cell Tissue Res] Abstract Mesenchymal Stem Cells Reduce Cigarette Smoke-Induced Inflammation and Airflow Obstruction in Rats via TGF-ß1 Signaling Researchers tested the effects of rat mesenchymal stem cells (rMSCs) on inflammation of the lungs and destructive pulmonary function induced by cigarette smoke in rats. rMSCs were cultured in vitro and infused intratracheally into cigarette smoke-exposed rats. [COPD] Abstract Co-Culture with Human Synovium-Derived Mesenchymal Stem Cells Inhibits Inflammatory Activity and Increases Cell Proliferation of Sodium Nitroprusside-Stimulated Chondrocytes Researchers examined the inhibitory effects on inflammatory activity from a co-culture of human synovium-derived mesenchymal stem cells and sodium nitroprusside-stimulated chondrocytes. [Biochem Biophys Res Commun] Abstract Crosstalk between Adrenergic and Toll-Like Receptors in Human Mesenchymal Stem Cells and Keratinocytes: A Recipe for Impaired Wound Healing Bone marrow-derived mesenchymal stem cells exposed to epinephrine significantly increased Toll-like receptor 2 (TLR2) message, TLR2 protein, and myeloid differentiation factor 88. [Stem Cells Transl Med] Abstract LRP6 in Mesenchymal Stem Cells Is Required for Bone Formation during Bone Growth and Bone Remodeling Researchers generated mice lacking lipoprotein receptor-related protein 6 (LRP6) expression specifically in nestin+ mesenchymal stem cells (MSCs) by crossing nestin-Cre mice with LRP6flox mice and investigated the functional changes of bone marrow MSCs and skeletal alterations. [Bone Res] Full Article |