Mesenchymal Cell News Volume 6.46 | Dec 9 2014

Human Mesenchymal Stromal Cells Enhance the Immunomodulatory Function of CD8⁺CD28⁻ Regulatory T Cells
Researchers studied the effects of mesenchymal stromal cells (MSCs) on CD8⁺CD28⁻ regulatory T cells and found that the MSCs could not only increase the proportion of CD8⁺CD28⁻ T cells, but also enhance CD8⁺CD28⁻T cells’ ability of hampering naive CD4⁺ T-cell proliferation and activation, decreasing the production of IFN-γ by activated CD4⁺ T cells and inducing the apoptosis of activated CD4⁺ T cells. [Cell Mol Immunol] Full Article

Differential Expression of Basal MicroRNAs’ Patterns in Human Dental Pulp Stem Cells
Dental pulp stem cells (DPSCs) were characterized in terms of their proliferation and differentiation capacity. Scientists observed 19 up-regulated microRNAs (miRNAs) and 29 significantly down-regulated miRNAs in DPSCs in comparison with bone marrow mesenchymal stem cells. [J Cell Mol Med] Full Article

In Vitro Cell Motility as a Potential Mesenchymal Stem Cell Marker for Multipotency
Bone marrow mesenchymal stem cells from various donors and in vitro passages were evaluated for their in vitro motility, and the distances were correlated to the adipogenic, chondrogenic, and osteogenic differentiation potentials and the levels of senescence and cell size. [Stem Cells Transl Med] Abstract

Mesenchymal Stem Cells Promote Liver Regeneration and Prolong Survival in Small-For-Size Liver Grafts: Involvement of C-Jun N-Terminal Kinase, Cyclin D1, and NF-κB
Researchers explored whether and how mesenchymal stem cells protected hepatocytes and stimulated allograft regeneration in small-for-size liver transplantation. [PLoS One] Full Article

Local Delivery of Mesenchymal Stem Cells with Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold Suppress Arthritis in Rats
Mesenchymal stem cells seeded on nano-fiber scaffold suppressed arthritis and bone destruction due to inhibition of systemic inflammatory reaction and immune response by suppressing T cell proliferation and reducing anti- type II collagen antibody production. [PLoS One] Full Article

In Vitro Mutual Interaction between Tenocytes and Adipose-Derived Mesenchymal Stromal Cells
Scientists evaluated the in vitro mutual interaction of adipose-derived mesenchymal stromal cells and tenocytes in standard culture conditions and a microwound healing model. [Cytotherapy] Abstract

Randomized, Double-Blind, Phase I/II Study of Intravenous Allogeneic Mesenchymal Stromal Cells in Acute Myocardial Infarction
A Phase I/II randomized, double-blind, single-dose study was conducted to assess the safety and efficacy of intravenous administration of Stempeucel versus placebo. Twenty patients who had undergone percutaneous coronary intervention for acute myocardial infarction were randomly assigned to receive intravenous Stempeucel or placebo and were followed for two years. [Cytotherapy] Abstract

Co(II)-Mediated Effects of Plain and Plasma Immersion Ion Implanted Cobalt-Chromium Alloys on the Osteogenic Differentiation of Human Mesenchymal Stem Cells
Cobalt-chromium alloy modified by nitrogen plasma immersion ion implantation was evaluated with regard to its effect on the osteogenic differentiation of mesenchymal stem cells. [J Orthop Res] Abstract

Mesenchymal Stem Cell Spheroids Exhibit Enhanced In Vitro and In Vivo Osteoregenerative Potential
Investigators assessed whether the osteoregenerative potential of mesenchymal stem cell (MSC) spheroids is greater than that of monolayer MSCs. [BMC Biotechnol] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Paul G. Allen to Give $100 Million to Create Cell Science Institute
Philanthropist and entrepreneur Paul G. Allen announced a commitment of $100 million to create the Allen Institute for Cell Science in Seattle. Founded to investigate and model the complex living machinery of cells, the nonprofit Allen Institute for Cell Science and its inaugural project, the Allen Cell Observatory, will accelerate disease research around the world by creating and sharing reagents, data and dynamic, predictive models of cells. [Allen Institute for Cell Science] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Postdoctoral Fellow – Cell Therapy and Bone Tissue Engineering (Etablissement Français du Sang Ile de France)

PhD Studentship – Mesenchymal Stem Cells (University of York)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Animal Surgery – Regenerative Medicine for Cardiac and Skeletal Muscle Disease (Duke University)

Postdoctoral Fellow – Physiology and Pharmacology of Human Skeletal Muscle Microtissues (Duke University)

Postdoctoral Position – Therapeutic Potential of Mesenchymal Stem Cells (IRSN – French Nuclear Safety Institute)

Assistant/Associate Research Scientist – Bone Healing and Metabolism (New York University)

Postdoctoral Fellow – Collaborative Training Program in Musculoskeletal Health Research (Western University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.