miR-30e Targets IGF2-Regulated Osteogenesis in Bone Marrow Derived Mesenchymal Stem Cells, Aortic Smooth Muscle Cells and ApoE-/- Mice In vitro, miR-30e over-expression reduced the proliferation of mesenchymal stem cells (MSCs) and smooth muscle cells (SMCs) while increasing adipogenic differentiation of MSCs and smooth muscle differentiation of SMCs. [Cardiovasc Res] Abstract Biomineralized Matrices Dominate Soluble Cues to Direct Osteogenic Differentiation of Human Mesenchymal Stem Cells through Adenosine Signaling Researchers investigated whether a bone-specific calcium phosphate mineral environment could induce osteogenic differentiation of human mesenchymal stem cells, while inhibiting their adipogenic differentiation, in the presence of adipogenic-inducing medium. [Biomacromolecules] Abstract Elucidating the Individual Effects of Calcium and Phosphate Ions on hMSCs by Using Composite Materials Clinically relevant bone marrow derived human mesenchymal stromal cells (hMSCs) were cultured on composites and proliferation, osteogenic differentiation and ECM mineralization were investigated with time and were compared to plain PLA control particles. [Acta Biomater] Abstract hiPS-MSCs Differentiation towards Fibroblasts on a 3D ECM Mimicking Scaffold A PEG-fibrinogen hydrogel infiltrated with connective tissue growth factor scaffold was found not only biocompatible with human induced pluripotent stem cells derived mesenchymal stem cells (hiPS-MSCs), but also presented intriguingly strong fibroblastic commitments, to an extent comparable to the positive control. [Sci Rep] Full Article Human Periapical Cyst-Mesenchymal Stem Cells Differentiate into Neuronal Cells Periapical inflammatory cysts were compared with dental pulp to determine whether this tissue may be an alternative accessible tissue source of mesenchymal stem cells that retain the potential for neurogenic differentiation. [J Dent Res] Abstract Contextual Niche Signals towards Colorectal Tumor Progression by Mesenchymal Stem Cell in the Mouse Xenograft Model Scientists aimed to determine whether heterotypic interactions between mesenchymal stem/stromal cells and colon cancer cells can supply contextual signals towards tumor progression. [J Gastroenterol] Abstract The Co-Transplantation of Bone Marrow Derived Mesenchymal Stem Cells Reduced Inflammation in Intramuscular Islet Transplantation Researchers co-cultured murine islets with mesenchymal stem cells (MSCs) and then analyzed the morphological changes, viability, insulin-releasing function, and gene expression of the islets. The destruction of islets tended to be prevented by co-culture with MSCs. [PLoS One] Full Article Alteration of Histone Acetylation Pattern during Long-Term Serum-Free Culture Conditions of Human Fetal Placental Mesenchymal Stem Cells Alterations to histone acetylation and consequence on the expression pattern of mesenchymal stem cells (MSCs) derived from placenta of fetal origin (fPMSCs) following in vitro propagation under serum-free conditions were explored. Scientists show that fPMSCs maintain their MSC characteristics before they reach a senescent state. [PLoS One] Full Article High Content and High throughput Screening to Assess the Angiogenic and Neurogenic Actions of Mesenchymal Stem Cells In Vitro Scientists investigated the effect of mesenchymal stem cell conditioned media on in vitro assays of angiogenesis and nerve growth. They describe the use of two state of the art high content and high throughput cell analysis systems and compare them against manual analysis techniques. [Exp Cell Res] Abstract |