Adipogenic Differentiation of hMSCs Is Mediated by Recruitment of IGF-1R onto the Primary Cilium Associated with Cilia Elongation Human mesenchymal stem cells (hMSCs) expressed primary cilia which were labelled with acetylated alpha tubulin and visualized by confocal microscopy. Chemically induced differentiation resulted in lineage specific changes in cilia length and prevalence independent of cell cycle. [Stem Cells] Abstract TGFβ3 Secretion by Three-Dimensional Cultures of Human Dental Apical Papilla Mesenchymal Stem Cells Scientists hypothesized that human dental apical papilla-derived mesenchymal stem cells (hSCAPs) can produce and secrete TGFβ3 in response to micro-environmental cues. For this, they encapsulated hSCAPs in different types of matrix and evaluated TGFβ3 secretion. [J Tissue Eng Regen Med] Abstract Influence of Bone Marrow-Derived Mesenchymal Stem Cells (MSCs) Pre-Implantation Differentiation Approach on Periodontal Regeneration In Vivo The implantation of bone marrow-derived MSCs has previously been shown successful to achieve periodontal regeneration. However, the preferred pre-implantation differentiation strategy to obtain optimal periodontal regeneration is still unknown. Researchers explored which differentiation approach is most suitable for periodontal regeneration. [J Clin Periodontol] Abstract Osteogenic Differentiation of Human Mesenchymal Stem Cells in 3-D Zr-Si Organic-Inorganic Scaffolds Produced by Two-Photon Polymerization Technique Zr-Si scaffolds with 150, 200, and 250 μm pore sizes were seeded with human bone marrow stem cells (hBMSCs) and human adipose tissue derived stem cells (hASCs) and cultured in osteoinductive and control media for three weeks. Osteogenic differentiation of hASCs and hBMSCs and formation of bone matrix was comparatively analyzed via alkaline phosphatase activity, calcium quantification, osteocalcin staining and scanning electron microscopy. [PLoS One] Full Article The Osteogenic Priming of Mesenchymal Stem Cells Is Impaired in Experimental Diabetes Scientists evaluated the functionality and osteogenic priming capability of bone marrow-derived mesenchymal stem cells, harvested from animals with experimental diabetes, and grown in the absence of any given differentiation factor. [J Cell Biochem] Abstract Improved Survival of Mesenchymal Stem Cells by Macrophage Migration Inhibitory Factor Scientists examined the protective effect of macrophage migration inhibitory factor on hypoxia/serum deprivation-induced apoptosis of mesenchymal stem cells (MSCs), as well as the possible mechanisms. MSCs were obtained from rat bone marrow and cultured in vitro. [Mol Cell Biochem] Full Article Enhanced Survival of Mice Infused with Bone Marrow-Derived as Compared to Adipose-Derived Mesenchymal Stem Cells Mesenchymal stem cells constitute a promising cell source for regenerative therapy and are frequently isolated from bone marrow or adipose tissue. Scientists assessed the characteristics of these two cell types and their safety for cell infusion. [Hepatol Res] Abstract Hypoxia-Induced Proliferation in Mesenchymal Stem Cells and Angiotensin II-Mediated PI3K/AKT Pathway Researchers determined angiotensin II mechanisms and PI3K/AKT pathway in hypoxia-induced proliferation of mesenchymal stem cells (MSCs). Hypoxia induced cellular proliferation in mouse MSCs and upregulated endogenous angiotensin II and angiotensin-converting enzyme in the cell culture and expression of AT1 receptors. [Cell Biochem Funct] Abstract |