Activation of Non-Myogenic Mesenchymal Stem Cells during the Disease Progression in Dystrophic Dystrophin/Utrophin Knockout Mice The authors showed that in contrast to myogenic progenitor cells (MPCs), non-myogenic mesenchymal stem cells (nmMSCs) become activated during disease progression in dystrophin/utrophin knockout (dKO) mice, displaying increased proliferation and differentiation potentials. They also found that after co-culturing the dKO-nmMSCs with dKO-MPCs, the myogenic differentiation potential of the dKO-MPCs was reduced. [Hum Mol Genet] Abstract Mesenchymal Stem Cell Exosomes Induce the Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro Scientists examined the role of mesenchymal stem cell (MSC) exosomes in wound healing. They found that MSCs exosomes ranged from 30 to 100-nm in diameter and internalization of MSC exosomes resulted in a dose-dependent enhancement of proliferation and migration of fibroblasts derived from normal donors and chronic wound patients. [Stem Cells Dev] Abstract Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells Combined with Low-Dose Rapamycin Induced Islet Allograft Tolerance via Suppressing Th1 and Enhancing Regulatory T Cell Differentiation Investigators showed that mesenchymal stem cells derived from induced pluripotent stem cells (iPSC-MSCs) combined with rapamycin significantly prolonged islet allograft survival in the diabetic mice. Histopathological analysis revealed that iPSC-MSCs combined with rapamycin preserved the graft effectively, inhibited inflammatory cell infiltration and resulted in substantial release of insulin. [Stem Cells Dev] Abstract Bone Marrow Mesenchymal Stem Cell Transplantation Retards the Natural Senescence of Rat Hearts The authors investigated the antiaging properties of bone marrow mesenchymal stem cells and the underlying mechanism in a cellular model of cardiomyocyte senescence and a rat model of aging hearts. [Stem Cells Transl Med] Abstract | Press Release Mesenchymal-Stem-Cell-Derived Exosomes Accelerate Skeletal Muscle Regeneration Researchers investigated the role of mesenchymal stem cell (MSC) exosomes in skeletal muscle regeneration. MSC exosomes promotes myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. [FEBS Lett] Abstract Icariin Induces Osteogenic Differentiation of Bone Mesenchymal Stem Cells in a MAPK-Dependent Manner Effects of icariin on cell proliferation and osteogenic differentiation of rat bone mesenchymal stem cells were systematically evaluated. To characterize underlying mechanisms, its effects on mitogen-activated protein kinase signaling pathways were determined. [Cell Prolif] Abstract Mesenchymal Stromal Cells Derived from Acute Myeloid Leukemia Bone Marrow Exhibit Aberrant Cytogenetics and Cytokine Elaboration Researchers characterized the cytokine and gene expression profile, immunophenotype and cytogenetics of bone marrow-derived mesenchymal stromal cells (BM-MSCs) from acute myeloid leukemia (AML) patients compared to normal BM-MSCs from healthy donors. AML BM-MSCs showed decreased monocyte chemoattractant protein-1 levels compared to normal BM-MSCs. [Blood Cancer J] Full Article Mesenchymal Stem Cells Facilitate In Vitro Development of Human Preantral Follicle Scientists investigated whether mesenchymal stem cells (MSCs) could help to reconstruct a microenvironment to facilitate the in vitro follicle development. They showed human MSCs significantly promotes the survival rates, increases the growth velocity, and improves the viability of preantral follicles in a dose-dependent manner. [Reprod Sci] Abstract |