Mesenchymal Cell News Volume 7.16 | Apr 28 2015

Synergistic Protection of N-Acetylcysteine and Ascorbic Acid 2-Phosphate on Human Mesenchymal Stem Cells against Mitoptosis, Necroptosis and Apoptosis
By using a systematic analysis, scientists revealed the mechanism of synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells that were under H₂O₂-induced oxidative stress. [Sci Rep] Full Article

Hypoxic Culture of Bone Marrow-Derived Mesenchymal Stromal Stem Cells Differentially Enhances In Vitro Chondrogenesis within Cell-Seeded Collagen and Hyaluronic Acid Porous Scaffolds
The authors assessed the effect of hypoxia on in vitro bone marrow mesenchymal stromal stem cell chondrogenesis within clinically approved porous scaffolds composed of collagen and hyaluronic acid. [Stem Cell Res Ther] Abstract | Full Article

Macrophage Migration Inhibitory Factor Confers Resistance to Senescence through CD74-Dependent AMPK-FOXO3a Signaling in Mesenchymal Stem Cells
Investigators found that mesenchymal stem cells (MSCs) isolated from the bone marrow of aged rats displayed reduced proliferative capacity, impaired ability to mediate paracrine signaling, and lower resistance to hypoxia/serum deprivation-induced apoptosis, when compared to younger MSCs. [Stem Cell Res Ther] Abstract | Full Article

Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells
The authors investigated effects of aspartic acid on ultraviolet A irradiation-induced damages in the stemness properties of human adipose tissue-derived mesenchymal stem cells. [PLoS One] Full Article

Melatonin Pre-Treatment of Human Adipose Tissue-Derived Mesenchymal Stromal Cells Enhances their Pro-Survival and Protective Effects on Human Kidney Cells
Researchers investigated the action of melatonin on adipose tissue-derived mesenchymal stromal cells (hASCs), as well as the effect of the resulting hASCs conditioned media on human kidney cells exposed to oxidative and apoptotic injury-provoking doses of cisplatin. [Am J Physiol Renal Physiol] Abstract

Periostin of Human Periodontal Ligament Fibroblasts Promotes Migration of Human Mesenchymal Stem Cell through the αvβ3 Integrin/FAK/PI3K/Akt Pathway
Researchers examined whether human periodontal ligament fibroblasts with high levels of periostin expression promoted the migration of human bone marrow mesenchymal stem cells. [J Periodontal Res] Abstract

Bone Marrow and Adipose-Derived Mesenchymal Stem Cells Alleviate Methotrexate-Induced Pulmonary Fibrosis in Rat: Comparison with Dexamethasone
Scientists examined the therapeutic effects of bone marrow mesenchymal stem cells and adipose-derived mesenchymal stem cells in methotrexate-induced pulmonary fibrosis in rats as compared with dexamethasone. [J Biochem Mol Toxicol] Abstract

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apceth Names Ulrike Verzetnitsch as Chief Technical Officer
The cell therapy company apceth GmbH & Co. KG is continuing to expand its senior management team and has announced the appointment of Ulrike Verzetnitsch as Chief Technical Officer with immediate effect. [apceth GmbH & Co. KG] Press Release

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Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Assistant/Associate/Full Professor – Stem Cell Biology & Regenerative Medicine (University of Illinois Chicago College of Medicine)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (AO Research Institute)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Cell Culture Specialist – Mesenchymal Stem Cell and Neural Stem Cell Cultures (Tisch MS Research Center of New York)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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