Mesenchymal Cell News Volume 7.22 | Jun 9 2015

miR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived from Osteoporotic Mice
Scientists found that miR-26a treatment could effectively improve the osteogenic differentiation capability of mesenchymal stem cells isolated from littermate-derived ovariectomized osteoporotic mice both in vitro and in vivo. [Mol Ther] Abstract

Crosstalk between Bone Marrow-Derived Mesenchymal Stem Cells and Regulatory T Cells through a Glucocorticoid-Induced Leucine Zipper/Developmental Endothelial Locus-1-Dependent Mechanism
The authors showed that expression of glucocorticoid-induced leucine zipper in bone marrow mesenchymal lineage cells or bone marrow-derived mesenchymal stem cells increases the production of regulatory T cells via a mechanism involving the up-regulation of developmental endothelial locus-1, an endogenous leukocyte-endothelial adhesion inhibitor. [FASEB J] Abstract

Epigenetic Memory Gained by Priming with Osteogenic Induction Medium Improves Osteogenesis and Other Properties of Mesenchymal Stem Cells
Researchers reported that after in vitro induction of osteogenic differentiation, mesenchymal stem cells could be reverted to a primitive stem cell population with improved cell survival, colony formation, osteogenic potential, migratory capacity and increased expression of Nanog, Oct4 and Sox2. [Sci Rep] Full Article

Potent Paracrine Effects of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Attenuate Doxorubicin-Induced Cardiomyopathy
In vitro studies reveal that doxorubicin-induced reactive oxidative stress generation and cell apoptosis in neonatal rat cardiomyocytes are significantly reduced when treated with conditioned medium harvested from bone marrow mesenchymal stem cells (MSCs) or induced pluripotent stem cell-derived-MSCs. [Sci Rep] Full Article

Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem Cells
Bone marrow-derived mesenchymal stem cells exposed to low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibited an elongated phenotype with diffuse intracellular F-actin, pronounced migratory leading edges, and filopodia-like projections. In addition, LMWF5A promoted chondrogenic condensation in “micromass” culture, concurrent with the upregulation of collagen 2α1 mRNA. [Stem Cells Transl Med] Abstract | Press Release

Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration
Scientists examined the colony formation and differentiation abilities of bone marrow-derived mesenchymal stem cells (MSCs) and synovium-derived MSCs isolated from the same patients. Both types of MSCs exhibited a marked propensity to differentiate into specific lineages. [PLoS One] Full Article

The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells
Researchers showed that quercetin significantly enhanced the cell proliferation, osteogenic differentiation and angiogenic factor secretion of rat bone marrow-derived mesenchymal stem cells in a dose-dependent manner, with a concentration of 2 μM achieving the greatest stimulatory effect. [PLoS One] Full Article

Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2
To clarify the mechanism underlying the multipotency of mesenchymal stem cells and to develop a novel approach to bone regenerative medicine, the authors identified the downstream effectors of Nanog in promoting osteogenic differentiation of mouse mesenchymal cells. [Cell Reprogram] Abstract

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Sanford Consortium, Takeda Pharmaceutical Partner in $10-Million “Innovation Alliance”
The Sanford Consortium for Regenerative Medicine and the Takeda Pharmaceutical Company Limited have agreed to establish a $10-million, five-year Innovation Alliance that would advance each organization’s research missions. [UC San Diego] Press Release

Creighton Researcher Earns NIH Grant to Study Gene, Stem Cell Therapy for Coronary Grafts
A Creighton University researcher has received a National Institutes of Health (NIH) grant to study the effects of gene and stem cell therapy in coronary artery bypass grafts, a first-of-its-kind undertaking that could transform the procedure, increase survival rates and dramatically reduce the possibility of re-occlusion of the grafted arteries and veins in the procedure. [Creighton University] Press Release

FDA Grants IND Approval for Phase IIa Clinical Trial Using Stemedica’s itMSC Therapy to Treat Alzheimer’s Disease
Stemedica Cell Technologies, Inc. received the FDA’s investigational new drug (IND) approval for a United States-based, Phase IIa clinical study using its allogeneic stem-cell therapy to treat subjects with mild to moderate dementia due to Alzheimer’s disease. [Stemedica Cell Technologies, Inc.] Press Release

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NEW Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Cardiff University)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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