Mesenchymal Cell News Volume 7.24 | Jun 23 2015

Neuroprotective Effect of Human Mesenchymal Stem Cells in a Compartmentalized Neuronal Membrane System
Investigators describe the development of a compartmentalized membrane system using neonatal rodent hippocampal cells and human mesenchymal stem cells (hMSCs) to investigate the neuroprotective effects of hMSCs. [Acta Biomater] Abstract

Isolation and Characterization of Human Mesenchymal Stromal Cells Subpopulations: Comparison of Bone Marrow and Adipose Tissue
Researchers performed immunomagnetic selections with five single surface markers to isolate mesenchymal stromal cell subpopulations from bone marrow and adipose tissue: CD271, SUSD2, MSCA-1, CD44 and CD34. They determined the phenotype, the clonogenicity, the proliferation, the differentiation capacity and the immunoregulatory profile of the sub-populations obtained in comparison with unselected cells. [Stem Cells Dev] Abstract

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells
Scientists report that actomyosin-generated cytoskeletal tension regulates nuclear shape and force transmission through the cytoskeleton and demonstrate the differential short- and long-term response of mesenchymal stem cells to dynamic tensile loading based on the contractility state, the patency of the actin cytoskeleton, and the connections it makes with the nucleus. [Biophys J] Abstract

Effects of Transplantation of CTLA4Ig-Overexpressing Adipose Tissue-Derived Mesenchymal Stem Cells in Mice with Sustained Severe Rheumatoid Arthritis
Investigators aimed to determine whether CTLA4Ig and human adipose tissue-derived mesenchymal stem cells showed synergistic effects on immunomodulation and clinical improvement of sustained severe rheumatoid arthritis in a mouse model. [Cell Transplant] Full Article

Low Extracellular Sodium Promotes Adipogenic Commitment of Human Mesenchymal Stromal Cells: A Novel Mechanism for Chronic Hyponatremia-Induced Bone Loss
The authors investigated the effects of a chronic reduction of extracellular sodium concentrations, independently of osmotic stress, on human mesenchymal stromal cells from bone marrow, the common progenitor for osteoblasts and adipocytes. [Endocrine] Abstract

Isolation, Culture, Differentiation, and Nuclear Reprogramming of Mongolian Sheep Fetal Bone Marrow-Derived Mesenchymal Stem Cells
Scientists characterized the differentiation potentiality and the developmental potential of cloned embryos of fetal bone marrow mesenchymal stem cells isolated from Mongolian sheep. [Cell Reprogram] Abstract

Regulation of Human Mesenchymal Stem Cell Differentiation by TREM-2
Scientists demonstrated that triggering receptor expressed on myeloid cells 2 (TREM-2) is expressed by human mesenchymal stem cells and responds to the toll-like receptor ligand lipopolysaccharide. [Hum Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

PrimeGen Biotech Reaffirms Its Commitment to Stem Cell Science – Opens New 10,000 Square Foot Research Facility and HQ
PrimeGen Biotech announced the opening of its new 10,000 square-foot research facility located in Santa Ana, California. PrimeGen’s new facility was designed to give its research team the space and tools necessary to delve deeper into the characterization of stem cells and their respective therapeutic value, while complying with FDA’s Current Good Manufacturing Practice regulations. [PrimeGen Biotech LLC (PR Newswire Association LLC)] Press Release

From our sponsor:
Webinar: Neural Stem Cell Culture Systems – Neurosphere vs. Adherent Monolayer Culture. Watch now.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the mesenchymal cell community.

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Cardiff University)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.