Mesenchymal Cell News Volume 7.27 | Jul 14 2015

A Role for MOSPD1 in Mesenchymal Stem Cell Proliferation and Differentiation
Researchers generated MOSPD1-null embryonic stem cells and demonstrated that they are deficient in their ability to differentiate into a number of cell lineages including osteoblasts, adipocytes and hematopoietic progenitors. [Stem Cells] Abstract

Rapid Fusion between Mesenchymal Stem Cells and Cardiomyocytes Yields Electrically Active, Non-Contractile Hybrid Cells
Researchers investigated direct interactions between human mesenchymal stem cells (hMSCs) and cardiomyocytes in vitro. Using a genetic Ca²⁺ indicator gCaMP3 to efficiently label hMSCs in co-cultures with neonatal rat ventricular myocytes (NRVMs), they determined that 25–40% of hMSCs acquired periodic Ca²⁺ transients and cardiac markers through spontaneous fusion with NRVMs. [Sci Rep] Full Article

Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances Their Differentiation toward Osteogenic Outcomes
Investigators describe the preparation of conductive fiber-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes. [Macromol Rapid Commun] Abstract

MicroRNA-103a-3p Controls Proliferation and Osteogenic Differentiation of Human Adipose Tissue-Derived Stromal Cells
To examine the role of the microRNA-103a-3p (miR-103a-3p) in human adipose tissue-derived stromal cells (hADSCs) functions, miR-103a-3p mimics were transfected into hADSCs in order to overexpress miR-103a-3p. Overexpression of miR-103a-3p inhibited the proliferation and osteogenic differentiation of hADSCs. [Exp Mol Med] Full Article

Biological Behavior of Mesenchymal Stem Cells on Poly-ε-Caprolactone Filaments and a Strategy for Tissue Engineering of Segments of the Peripheral Nerves
Scientists describe the interaction between poly-caprolactone (PCL) filaments and mesenchymal stem cells (MSC), aiming to optimize peripheral nervous system tubular implants. MSC were plated on PCL filaments for 48 hours and the adhesion profile, viability, proliferation and paracrine capacity were evaluated. [Stem Cell Res Ther] Abstract | Full Article

Useful Properties of Undifferentiated Mesenchymal Stromal Cells and Adipose Tissue as the Source in Liver-Regenerative Therapy Studied in an Animal Model of Severe Acute Fulminant Hepatitis
Researchers analyzed whether undifferentiated mesenchymal stromal cells (MSCs) or MSC-derived hepatocyte-like cells from adipose tissue, umbilical cord blood and bone marrow would better restore damaged liver. [Cytotherapy] Abstract

MicroRNA-153 Suppresses the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting Bone Morphogenetic Protein Receptor Type II
Scientists examined the role of microRNA (miR)-153 in the osteogenesis of human mesenchymal stem cells and investigated the impact of miR-153 on bone morphogenetic protein receptor type II expression. [Int J Mol Med] Abstract

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Groundbreaking Clinical Trial to Assess Use of Newborn Stem Cells in the Treatment of Pediatric Stroke
Cord Blood Registry^® announced the launch of an FDA-regulated clinical trial to investigate autologous stem cell therapy in children diagnosed as having had a prenatal or perinatal pediatric stroke. [Cord Blood Registry^®] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Researcher – Stem Cell Research (Helse Bergen – Haukeland University Hospital)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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