Mesenchymal Cell News Volume 7.34 | Sep 1 2015

Health Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats
Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives. Transplantation of AMMSCs and ADMSCs improved cognitive and physical functions of naturally aging rats, extending life span by 23.4% and 31.3%, respectively. [Stem Cells Transl Med] Abstract | Press Release

Bile Acids Induce Hepatic Differentiation of Mesenchymal Stem Cells
Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-derived mesenchymal stem cells (MSC) was investigated. Physiological concentrations of bile acids such as tauroursodeoxycholic acid were able to initiate hepatic differentiation of MSC via the farnesoid X receptor and transmembrane G-protein-coupled bile acid receptor 5 as investigated with knockout mice. [Sci Rep] Full Article

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses
Scientists found that, along with Th1 responses, hMSCs strongly suppressed interleukin-17A (IL-17A)-secreting T (Th17) responses and this required both IL-25—also known as IL-17E—as well as programmed death ligand-1 (PD-L1), a potent cell surface ligand for tolerance induction. [Stem Cell Rep] Full Article | Graphical Abstract

Isolation, Selection and Culture Methods to Enhance Clonogenicity of Mouse Bone Marrow Derived Mesenchymal Stromal Cell Precursors
The authors aimed to optimize the isolation, culture conditions and selection of mouse bone marrow mesenchymal stromal cells. [Stem Cell Res Ther] Full Article

Human Amniotic Mesenchymal Stromal Cells (hAMSCs) as Potential Vehicles for Drug Delivery in Cancer Therapy: An In Vitro Study
The authors investigated mesenchymal stromal cells isolated from the amniotic membrane of human term placenta as candidates for drug delivery in vitro. [Stem Cell Res Ther] Full Article

Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke–Induced COPD in C57BL/6 Mice
Scientists studied the effectiveness of human tube derived mesenchymal stromal cells cell therapy associated with low level laser irradiation in experimental cigarette smoke-induced chronic obstructive pulmonary disease. [PLoS One] Full Article

Human Schwann-Like Cells from Adipose-Derived Mesenchymal Stem Cells Rapidly De-Differentiate in the Absence of Stimulating Media
Researchers examined the stability of differentiated adipose-derived stem cells (dASC) by withdrawing differentiation media for 72 hours after the full 18-day differentiation protocol, and measuring changes in morphology, gene expression and protein levels. Withdrawal of differentiation media from dASC resulted in a rapid reversion to stem cell-like characteristics. [Eur J Neurosci] Abstract

Role of Suppressor of Cytokine Signaling 3 in the Immune Modulation of Mesenchymal Stromal Cells
The authors showed that the suppressor of cytokine signaling 3 is an important immune modulator expressed by mesenchymal stromal cells, which is significantly increased by interferon-γ. [Inflammation] Abstract

Type I and II Diabetic Adipose-Derived Stem Cells Respond In Vitro to Dehydrated Human Amnion/Chorion Membrane Allograft Treatment by Increasing Proliferation, Migration, and Altering Cytokine Secretion
Dehydrated human amnion/chorion membrane allografts were evaluated for their ability to regulate diabetic stem cells in vitro. [Adv Wound Care] Abstract | Press Release

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Cell Therapy Catapult Welcomes Planning Decision for Manufacturing Center
The Cell Therapy Catapult has welcomed the decision by Stevenage Borough Council to grant planning permission to construct its £55 million large-scale GMP manufacturing center. [Cell Therapy Catapult] Press Release

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