Mesenchymal Cell News Volume 7.43 | Nov 3 2015

Immune Modulatory Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells through a Trophoblast-Like Stage
Scientists describe a novel method to rapidly and efficiently produce mesenchymal stem/stromal cells (MSCs) from human embryonic stem cells via a trophoblast-like intermediate stage in about 11 to 16 days. They termed these cells “T-MSCs” and showed that T-MSCs express a phenotype and differentiation potential minimally required to define MSCs. [Stem Cells] Abstract

Cross-Talk between Chronic Lymphocytic Leukemia (CLL) Tumor B Cells and Mesenchymal Stromal Cells (MSCs): Implications for Neoplastic Cell Survival
The authors evaluated whether MSCs influence in vitro CLL cell survival. Following co-culture of MSCs and leukemic B cells, they demonstrated that MSCs were able to improve leukemic B cell viability, this latter being differently dependent from the signals coming from MSCs. [Oncotarget] Full Article

A Novel Antagonist of CXCR4 Prevents Bone Marrow-Derived Mesenchymal Stem Cell-Mediated Osteosarcoma and Hepatocellular Carcinoma Cell Migration and Invasion
Scientists investigated the role of bone marrow-derived mesenchymal stem cells in promoting osteosarcoma and hepatocellular carcinoma cell progression in vitro and the possible mechanisms involved in these processes. [Cancer Lett] Abstract

Mesenchymal Stem Cells Exhibit Regulated Exocytosis in Response to Chemerin and IGF
Investigators report that mesenchymal stem cells exhibit regulated exocytosis. Both a G-protein coupled receptor agonist, chemerin, and a receptor tyrosine kinase stimulant, IGF-II, evoked rapid increases in secretion of a marker protein, TGFβig-h3. [PLoS One] Full Article

Interferon-α2b Gene-Modified Human Bone Marrow Mesenchymal Stem Cells Inhibit Hepatocellular Carcinoma by Reducing the Notch1 Levels
Investigators studied the anti-tumor effect of a novel gene delivery system – IFN-α2b gene-modified human bone marrow mesenchymal stem cells in hepatocellular carcinoma. [Life Sci] Abstract

Enhanced In Vitro Osteogenic Differentiation of Human Fetal MSCs Attached to 3D Microcarriers versus Harvested from 2D Monolayers
The authors characterized human fetal MSCs after expansion in 3D microcarrier spinner or 2D monolayer cultures. Following expansion, they compared osteogenic differentiation of cultures seeded with 3D microcarrier (MC)-harvested, 3D MC-bound and conventional 2D monolayer-harvested cells when cultured in osteogenic induction media on collagen-coated plates. [BMC Biotechnol] Full Article

IN VIVO

Adipose-Derived Mesenchymal Stem Cells Improve Glucose Homeostasis in High-Fat Diet-Induced Obese Mice
Scientists evaluated whether a single intravenous infusion of syngeneic adipose-derived mesenchymal stem cells can reduce obesity, lower insulin resistance, and improve glucose homeostasis in a high-fat diet-induced obese mouse model. [Stem Cell Res Ther] Full Article

Aspirin Promotes Bone Marrow Mesenchymal Stem Cell-Based Calvarial Bone Regeneration in Mini Swine
Researchers investigated whether aspirin is capable of accelerating the regenerative potential of bone marrow mesenchymal stem cells in a mini swine calvarial bone defect model. [Stem Cell Res Ther] Full Article

Co-Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells and Schwann Cells through Cerebral Spinal Fluid for the Treatment of Patients with Chronic Spinal Cord Injury: Safety and Possible Outcome
Researchers assessed the safety and feasibility of bone marrow mesenchymal stem cell and Schwann cell co-injection through cerebral spinal fluid for the treatment of patients with chronic spinal cord injury. [Spinal Cord] Abstract

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Key United States Patent Granted for the Treatment of Heart Diseases, Stroke and other Vascular Conditions
Mesoblast Limited announced that the United States Patent and Trademark Office has granted a key patent covering the use of the company’s proprietary adult mesenchymal precursor cells for the formation and repair of blood vessels in ischemic tissues. [Mesoblast Limited] Press Release

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NEW Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

NEW Faculty Positions – Stem Cell Biology (University of Notre Dame)

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Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Association)

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