Mesenchymal Cell News Volume 8.14 | Apr 12 2016

The Supportive Role of Insulin-Like Growth Factor-I in the Differentiation of Murine Mesenchymal Stem Cells into Corneal-Like Cells
This study was focused on characterizing the differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into corneal-like cells. Mouse MSCs were isolated from the bone marrow, grown in cell culture for three weeks and purified using a magnetic activated cell sorter. Purified MSCs were cultured with an extract prepared from excised corneas and in the presence or absence of insulin-like growth factor-I. [Stem Cells Dev] Abstract

Differentiation of Hepatocytes from Induced Pluripotent Stem Cells Derived from Human Hair Follicle Mesenchymal Stem Cells
Investigators explored whether mesenchymal stem cells separated from human hair follicles (HF-MSCs) and HF-MSC-derived-induced pluripotent stem cells could differentiate into hepatocytes in vitro. [Cell Tissue Res] Abstract

Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Expressing Elastin Alleviates Pelvic Floor Dysfunction
In an in vitro cell culture system of seven days, when no additional bFGF was administrated, the initial poly (lactic-co-glycolic acid)-loaded bFGF nanoparticle induced prolonged production of collagen and elastin from elastin-expressing bone marrow-derived mesenchymal stem cells. [Stem Cell Res Ther] Abstract

Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold
The authors investigated the osteogenesis and chondrogenesis potentials of mesenchymal stem cells seeded onto nano-fiber scaffolds in vitro and possible use for the repair of rheumatoid arthritis-affected joints. [PLoS One] Full Article

Microvesicles Enhance the Mobility of Human Diabetic Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro and Improve Wound Healing In Vivo
Researchers characterized non-diabetic adipose tissue-derived mesenchymal stem cell (nAT-MSC)-derived microvesicles (MVs) and their function after the transfection of diabetic adipose tissue derived (dAT)-MSCs with MVs using the scratch assay and a flap mouse model. The authors found that human nAT-MSC-derived MVs expressed MSC-surface markers and improved dAT-MSC functions by altering the expression of genes associated with cell migration, survival, inflammation, and angiogenesis as well as miR29c and miR150. [Biochem Biophys Res Commun] Abstract

IN VIVO

Bone-Marrow-Derived Mesenchymal Stem Cells Inhibit Gastric Aspiration Lung Injury and Inflammation in Rats
Researchers investigated the effects of bone-marrow-derived mesenchymal stem cells (BMSCs) on combined acid plus small non-acidified particle (CASP)-induced aspiration lung injury. Enhanced green fluorescent protein (EGFP⁺) or EGFP⁻ BMSCs or 15d-PGJ₂ were injected via the tail vein into rats immediately after CASP-induced aspiration lung injury. [J Cell Mol Med] Abstract

Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
Researchers investigated the effect of intramyocardial injection of human mesenchymal stromal cells pre-stimulated with the pro-inflammatory cytokine interferon-gamma, since pro-inflammatory priming has shown additional salutary effects in multiple experimental disease models. [PLoS One] Full Article

Immune Modulation with Primed Mesenchymal Stem Cells Delivered via Biodegradable Scaffold to Repair an Achilles Tendon Segmental Defect
The in vivo healing effects of TNF-α primed mesenchymal stem cells (MSCs) were studied using a rat Achilles segmental defect model. Rat Achilles tendons were subjected to a unilateral 3 mm segmental defect and repaired with either a PLG scaffold alone, MSC-seeded PLG scaffold, or TNF-α-primed MSC-seeded PLG scaffold. [J Orthop Res] Abstract

Intratracheal Transplantation of Mesenchymal Stem Cells Simultaneously Attenuates both Lung and Brain Injuries in Hyperoxic Newborn Rats
The authors investigated whether attenuation of hyperoxic lung injury with intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells could simultaneously mitigate brain damage in neonatal rats. [Ped Res] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Clinical Trial Involving Regenerative Cell Treatment for Patients with Traumatic Brain Injury Permitted in Japan
SanBio, Inc. announced that they are now able to conduct the world’s first global Phase II clinical trial for chronic traumatic brain injury with allogeneic stem cells in Japan. [SanBio, Inc.] Press Release

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Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Training Fellow – Molecular and Stem Cell Biology (The Francis Crick Institute)

Postdoctoral Research Associate – Stem Cell Biology and Cell Differentiation (University of Illinois Chicago College of Medicine)

Postdoctoral Position – Epigenetic Regulation of Cell Fate, Cancer and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

Cell Culture Technician (California Institute of Technology)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Two Early Stage Researchers/PhD Fellowships – Tendon Therapy (NUI Galway)

Independent Group Leaders – Regenerative Medicine (Center of Regenerative Medicine in Barcelona)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)

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