Mesenchymal Cell News Volume 8.21 | May 31 2016

TOP STORY

Influence of Particulate and Dissociated Metal-on-Metal Hip Endoprosthesis Wear on Mesenchymal Stromal Cells In Vivo and In Vitro

Researchers introduced an assessment of the in vivo exposure to particulate and dissociated cobalt and chromium and evaluated the effects of metal-on-metal (MoM)-wear on mesenchymal stromal cells (MSCs). The exposure to MoM-wear products in vivo and in vitro lead to a decrease in MSCs’ osteogenic matrix mineralization and alkaline phosphatase activity on a cellular and systemic level. [Biomaterials] Abstract

(Ranked by impact factor of the journal)

IN VITRO

Mesenchymal Stromal Cells Generated from Pooled Mononuclear Cells of Multiple Bone Marrow Donors as a Rescue Therapy for Children with Severe Steroid-Refractory Graft versus Host Disease: A Multicenter Survey

To circumvent donor-to-donor heterogeneity which may lead to inconsistent results after treatment of acute graft-versus-host disease with mesenchymal stromal cells generated from single donors the authors developed a novel approach by generating these cells from pooled bone marrow mononuclear cells of eight healthy third-party donors. [Haematologica] Abstract

Eicosapentaenoic Acid Attenuates Dexamethasome-Induced Apoptosis by Inducing Adaptive Autophagy via GPR120 in Murine Bone Marrow-Derived Mesenchymal Stem Cells

Scientists showed that eicosapentaenoic acid (EPA)-induced autophagy of murine bone marrow-derived mesenchymal stem cells (mBMMSCs). Meanwhile, EPA, but not arachidonic acid, markedly inhibited Dex-induced apoptosis and promoted the viability of mBMMSCs. [Cell Death Dis] Full Article

Mesenchymal Stem Cells Suppress Cardiac Alternans by Activation of PI3K Mediated Nitroso-Redox Pathway

Calcium transient alternans is suppressed by human mesenchymal stem cells in a paracrine fashion due to activation of a PI3K-mediated nitroso-redox pathway. [J Mol Cell Cardiol] Abstract

Role of Fibroblast Growth Factor-5 on the Proliferation of Human Tonsil-Derived Mesenchymal Stem Cells

Researchers compared the proliferative potential of T-mesenchymal stem cells (MSCs) with BM-MSCs and adipose tissue-derived MSCs. Additionally, they investigated the underlying mechanism of T-MSC function. [Stem Cells Dev] Abstract

Hyaluronic Acid Enhances Proliferation of Human Amniotic Mesenchymal Stem Cells through Activation of Wnt/β-Catenin Signaling Pathway

The authors investigated the pro-proliferative effect of hyaluronic acid (HA) on human amniotic mesenchymal stem cells and the underlying mechanisms. Treatment with HA increased cell population growth in a dose- and time-dependent manner. [Exp Cell Res] Abstract

Perlecan Is Required for the Chondrogenic Differentiation of Synovial Mesenchymal Cells through Regulation of Sox9 Gene Expression

The authors examined the role of perlecan in the proliferation and differentiation of synovial mesenchymal cells, using a recently established mouse synovial cell culture method. [J Orthop Res] Abstract

Transcriptome Changes during TNF-α Promoted Osteogenic Differentiation of Dental Pulp Stem Cells (DPSCs)

Investigators examined the gene expression profiles between undifferentiated, partially differentiated and fully differentiated DPSCs induced by TNF-α by performing the next-generation sequencing technique. [Biochem Biophys Res Commun] Abstract

IN VIVO

Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an Off-the-Shelf Therapy

Investigators examined the effect of cryopreservation on human mesenchymal stromal cells viability, immunomodulatory potency, growth factor secretion, and performance in an ischemia/reperfusion injury model. [Sci Rep] Full Article

Comparison between Stromal Vascular Fraction and Adipose Mesenchymal Stem Cells in Remodeling Hypertrophic Scars

Scientists evaluated the effect of human adipose tissue-derived mesenchymal stem cells (hASC) on a pre-existing hypertrophic scars in a humanized skin graft model in Nude mice and to compare the efficacy of hASCs versus stromal vascular fraction. [PLoS One] Full Article

Concise Review: Pancreatic Cancer and Bone Marrow-Derived Stem Cells

The authors summarize experimental, translational, and/or clinical evidence regarding the contribution of bone marrow-derived mesenchymal stem cells, endothelial progenitor cells, hematopoietic stem/progenitor cells, and pancreatic stellate cells in pancreatic cancer development/progression. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Biogen Announces Collaboration with University of Pennsylvania on Multiple Gene Therapy Programs

Biogen announced a broad collaboration and alliance with the University of Pennsylvania to advance gene therapy and gene editing technologies. The expansive research and translational development collaboration has multiple objectives, but will primarily focus on the development of therapeutic approaches that target the eye, skeletal muscle and the central nervous system. [Biogen] Press Release

Nano Dimension and Accellta Joined Forces to Successfully BioPrint Stem Cell-Derived Tissues

Nano Dimension Ltd. announced it has successfully lab-tested a proof of concept 3D Bioprinter for stem cells. The trial was conducted in collaboration with Accellta Ltd. [Nano Dimension Ltd. (PR Newswire Association LLC.)] Press Release

Overtime Pay for Postdoctoral Scientists Is Welcome — But Could Mean Fewer Positions

In a long-overdue revision of American overtime regulations, the Department of Labor explicitly included postdocs among those who are eligible for overtime pay if they earn less than $47,476 per year. [Nature News] Editorial

NEW 2016 TERMIS Asia Pacific
September 3-6, 2016
Taipei, Taiwan

Visit our events page to see a complete list of events in the mesenchymal cell community.

NEW Postdoctoral Research Fellow – Neurobiology (McLean Hospital/Harvard Medical School)

NEW Postdoctoral Positions – Immunology, Cancer, and Stem Cells (The University of Connecticut)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois, College of Medicine)

Postdoctoral Positions – Regenerative Medicine (Gladstone Institutes)

Professor – Hematology and Cell Therapy (Karolinska Institutet)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, Los Angeles)

Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

Postdoctoral Scholar – Neurobiology (Penn State College of Medicine)

Postdoctoral Fellow – Tissue Regeneration (University of Pennsylvania)

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